Lamellar Hole-Associated Epiretinal Proliferation in Lamellar Macular Hole and Full-Thickness Macular Hole in High Myopia

Lai, Tso‐Ting; Yang, Chung–May

doi:10.1097/iae.0000000000001708

Cited by 40 publications

(42 citation statements)

References 16 publications

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“…Besides, previous studies also indicated that LMH or FTMH eyes with LHEP had worse visual outcomes after surgery [8,13,14,24], probably attributable to the severer destruction of the retina in eyes with LHEP than without LHEP. However, there are also some studies reported similar surgery outcomes of eyes with and without LHEP [10,12,15,16]. As there are no signi cant differences in preoperative BCVA (<20/40), surgery method (ILM and ERM peeling) and time of follow-up (>6 months) among these two kinds of studies, more studies with longer follow-up are required to determine the relationship between the poor visual outcomes and LHEP.…”

Section: Discussionmentioning

confidence: 98%

“…By reading the titles and abstracts, 14 papers on LHEP reporting surgical outcomes were identi ed. Then, the full texts of all articles were read and 6 of them were discarded because they included patients with FTMH [8,9], recruited LMH patients with high myopia [10], had incomplete information [11,12] or was an observational study without surgery [3]. Finally, eight studies with 176 eyes without LHEP and 173 eyes with LHEP were included [13][14][15][16][17][18][19][20].…”

Section: Characteristics Of the Available Studiesmentioning

confidence: 99%

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Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

Qin

Zhang

et al. 2020

Preprint

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Background: Given the two different kinds of epiretinal membranes, this study aimed to compare both the structural and functional outcomes of lamellar macular holes with and without lamellar hole-associated epiretinal proliferation (LHEP) after surgery.Method: Publications up to July 2020 that compared the surgical outcomes of lamellar macular hole with and without LHEP were included. Forest plots were created by using a weighted summary of proportion meta-analysis. Fixed or random effects models were used on the basis of I2 heterogeneity estimates. Meanwhile, to evaluate the stability of the meta-analysis, a sensitivity analysis was carried out.Results: Eight pertinent publications that contained a total of 176 eyes without LHEP and 173 eyes with LHEP were included. They were all retrospective studies and had a follow-up of at least 6 months. In all studies, the preoperative best corrected visual acuity showed no significant differences between the two groups, and the visual acuity improved in both groups after surgery. The pooled result for the improved best corrected visual acuity was 0.18 (95% confidence interval (CI), 0.10 to 0.26; P< 0.01) between the with and without LHEP groups. The restored ellipsoid zone odds ratio was 0.80 (95% CI, 0.26 to 2.44; P= 0.69) for the group with LHEP compared to the group without LHEP.Conclusion: Patients without LHEP had better postoperative visual acuity than patients with LHEP. No significant difference in restored ellipsoid zone was found between the two groups.

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Section: Discussionmentioning

confidence: 98%

Section: Characteristics Of the Available Studiesmentioning

confidence: 99%

Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

Qin

Zhang

et al. 2020

Preprint

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“…LMH is idiopathic in most cases, but it may be secondary to: cystoid macular edema due to metabolic or vascular retinal diseases [25-29], retinochoroiditis [30], age-related macular degeneration [31], retinitis pigmentosa [32], X-linked retinoschisis [33], myotonic dystrophy [34], Alport syndrome [35], Coats’ disease [36], high myopia [10, 37-40], ocular trauma [41, 42], or iatrogenic damage during intravitreal injection or surgery [43-48]. …”

Section: Pathogenesismentioning

confidence: 99%

Lamellar Macular Hole: State of the Art

Frisina

Pilotto

Midena³

2019

Ophthalmic Res

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Lamellar macular hole (LMH) is a vitreoretinal disorder characterized by an irregular foveal contour, a break in the inner fovea, dehiscence of the inner foveal retina from the outer retina, and the absence of a full-thickness foveal defect with intact foveal photoreceptors. The pathogenesis is only partially known. The advent of high-resolution optical coherence tomography has allowed distinguishing between two types of epiretinal membrane (ERM) associated with LMH: a conventional ERM (commonly found in macular pucker) and an atypical ERM (known by varied names: dense, epiretinal proliferation, or degenerative). These two types of ERM not only influence LMH morphology but also differ in cell and collagen composition. It remains unclear if these two types are indeed two distinct clinical entities or rather two stages of the same macular disorder. Studies of the natural evolution of LMH have not fully resolved this issue and also offered variable results. Surgical treatment leads to excellent anatomical and functional outcomes, but not without risks. This review provides a critical summary of the available data on LMH including some new insights.

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“…Опираясь на данные собственных наблюдений, T.T. Lai et al (2016Lai et al ( , 2018 пришли к выводу, что результаты хирургического лечения на глазах с LHEP и без неё идентичны, несмотря на больший процент повреждения эллипсоидной зоны в первом случае [51], а результаты хирургического лечения несквозных и сквозных макулярных разрывов с LHEP при высокой миопии не настолько благоприятны, как при эмметропии [52].…”

Section: результаты хирургического лечения и их прогнозированиеunclassified

Modern notions about the tactics of treatment of patients with non-full thickness macular holes: to observe or to operate?

Zhogolev

Сергеевич²,

Bayborodov

et al. 2019

Ophthalmology Reports

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In this review, the opinions of different authors on the problem of non-full thickness macular holes are discussed in detail. Currently, there are three different approaches to the management of this condition. Dynamic observation allows assessing the degree of their progression, to determine some or other anatomical indicators which influence the functional state of the retina and visual function. Pharmacological vitreolysis in some cases allows eliminating vertical and tangential traction in a least invasive mannor. To resolve this problem in a radical way is possible by surgical treatment posterior vitrectomy, but this is also related to certain surgical risks, and does not always lead to an increase in visual acuity. As a rule, it is recommended to patients with a significant decrease in visual acuity. Currently, indications for surgical treatment of patients with high visual function are ambiguous.

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Lamellar Hole-Associated Epiretinal Proliferation in Lamellar Macular Hole and Full-Thickness Macular Hole in High Myopia

Cited by 40 publications

References 16 publications

Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

Lamellar Macular Hole: State of the Art

Modern notions about the tactics of treatment of patients with non-full thickness macular holes: to observe or to operate?

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