Lambert-Eaton Myasthenic Syndrome Associated with Synchronous Double Cancer: A Combination of Small Cell Carcinoma of the Cervix and Breast Carcinoma

Fukuda, Hiroyuki; Hirashima, Yasuyuki; Ito, Ichiro

doi:10.2169/internalmedicine.0428-17

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…2 There have been several terms used to refer to SCCC due to its low incidence, including small cell neuroendocrine tumors, small cell undifferentiated carcinoma, argyrophilic cell carcinoma, and endocrine intermediate cell carcinoma. 5,6 It was not until 2007 when the term small-cell carcinoma was used in the General Rules of Clinical and Pathological Management of the Uterine Cervix that SCCC was classified as an independent disease because of its distinct clinicopathologic characteristics, deteriorating clinical progression, and markedly poor prognosis. 2,7,8 SCCC is known to have a predilection for lymph node (LN) involvement during the early stages of the disease, leading to poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

<p>Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage</p>

Huang¹,

Gan²,

Cheng³

2020

CMAR

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Purpose: Small-cell carcinoma of the cervix (SCCC) is a rare type of cervical cancer. This study aimed to investigate the clinicopathological characteristics and survival as well as the optimal local treatment modalities for SCCC. Patients and Methods: We retrospectively evaluated the data of patients diagnosed with SCCC between 1988 and 2015 in our institutionthose included in the Surveillance, Epidemiology, and End Results (SEER) database and those in the Periodical Database. Kaplan-Meier method and Cox regression proportional hazard methods were used to evaluate overall survival (OS). A nomogram that could predict OS was constructed based on the Cox proportional hazard model. Results: In total, 695 patients were included in this study. The 5-year overall survival in FIGO stage I-IIA and IIB-IV patients was 45.7% and 14.4%, respectively (P <0.01). Univariate and multivariate analyses showed that lymph node status (P <0.01) and cancerdirected surgery (P <0.01) were independent prognostic factors for FIGO I-IIA stage patients, and age (P <0.05), tumor size (P <0.01), chemotherapy (P <0.01) and radiation (P <0.01) were independent prognostic factors for FIGO stage IIB-IV patients. Conclusion: Better prognosis was associated with negative lymph node status, no lymphatic vasculature, surgery, and early-stage patients. Furthermore, our data showed that the prognosis and treatment pattern varied depending on the FIGO stage, and that optimal treatment modalities included radical surgery for early-stage SCCC and chemoradiotherapy for advanced-stage SCCC. It is helpful to assess the individual prognosis of SCCC patients and choose personalized treatment modalities.

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Section: Introductionmentioning

confidence: 99%

<p>Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage</p>

Huang¹,

Gan²,

Cheng³

2020

CMAR

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“…The occurrence and reporting of multiple cancers associated with breast cancer is common. Previous case reports (16)(17)(18)(19)(20)(21) have identified a number of types of multiple cancers associated with breast cancer, including skin cancer, gastrointestinal cancer, colon cancer, hematologic tumors, sarcomas, lung cancer, gynecologic tumors, thyroid cancer and urinary malignancies (16). There is a close association between breast cancer and gynecological tumors, especially ovarian cancer, because they share similar risk factors such as early menarche, advanced age without childbearing, obesity and high-fat diet (22,23).…”

Section: Discussionmentioning

confidence: 99%

Multiple synchronous primary malignant neoplasms: A case report and literature review

Hao,

Zhang,

et al. 2023

Oncol Lett

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Multiple primary malignant neoplasms (MPMN) are defined as two or more primary malignancies diagnosed in an individual. There is no association between these cancers, which can be classified into synchronous and heterochronous cancers depending on the time of diagnosis. The present study presented a rare case of bilateral breast, endometrial, cervical and ovarian cancers. Through thorough physical examination, pathology and immunohistochemistry, it could be determined that bilateral breast, endometrial and cervical cancers were primary malignant tumors and that ovarian cancer cannot be excluded as a result of metastasis. The present study also summarized the definitions, risk factors, prevalence characteristics, diagnostic ideas and treatment options for MPMN by reviewing the literature.

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“…La investigación reportada por [4] explica el caso de LEMS asociado con el cáncer doble sincrónico, que es una combinación de carcinoma de células pequeñas del cuello uterino y carcinoma de mama. El diagnóstico y tratamiento temprano de LEMS es importante para lograr un buen resultado.…”

Section: Discussionunclassified

“…Es muy difícil distinguir clínicamente una malignidad mamaria primaria de un depósito metastásico. En el estudio de [4] se indica que el síndrome miasténico de Lambert-Eaton (LEMS) se asocia con el carcinoma pulmonar de células pequeñas, mientras que rara vez con el carcinoma ginecológico y de mama.…”

Section: Introductionunclassified

Squamous Cell Metastasis of Cancer from Cervix to Breast: A Case Report

Romero

ópez

Donoso

et al. 2021

espoch

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Squamous cell metastasis from cervical cancer to breast is an extremely rare entity, approximately 29 cases have been documented worldwide since 1947 and it is the second documented case in Ecuador, the incidence is very low, it represents only 1,2 of all malignant neoplasms of the breast, which limits the expertise in the diagnosis and treatment of this metastasis, with the outermost quadrant of the breasts being the most frequent site of presentation. We present the clinical case of a 46-year-old married woman with a history of stage IVB squamous cell cancer of the cervix, who received chemotherapy, a Paclitaxel/Carboplatin regimen for 6 cycles. There was no good response and we had radiotherapy and brachytherapy treatment. The second line of chemotherapy with monodroga Gemcitab is proposed, the scheme is completed for 8 cycles. There is no favorable response, so a second-line chemotherapy treatment with Ifosfomide is proposed. The same metastases are present in the breast as after imaging and pathology examinations, it is concluded that the patient presents cervical Ca squamous cell metastases (cancer) from the cervix, 6 months after the diagnosis of the deceased patient. Metastasis to the breast from a neoplasm of other organs is very rare, the incidence of which is very low and the prognosis is gloomy. Keywords: metastasis, squamous cells, cancer of the cervix. RESUMEN La metástasis de células escamosas de cáncer de cérvix a mama es una entidad extremadamente rara, se ha documentado a nivel mundial aproximadamente 29 casos desde 1947 y es el segundo caso documentado en el Ecuador, la incidencia es muy baja, representa tan solo el 1,2 de todas las neoplasias malignas de la mama, lo que limita la experticia en el diagnóstico y tratamiento de esta metástasis, siendo el sitio más frecuente de presentación el cuadrante superior externo de las mamas. Se presenta el caso clínico de una paciente de 46 años, casada, con antecedentes de cáncer de cérvix de células escamosas en estadio IVB por lo que recibió tratamiento de quimioterapia, esquema Paclitaxel/Carboplatino por 6 ciclos. No hubo buena respuesta y recibió tratamiento de radioterapia y braquiterapia. Se propone segunda línea de quimioterapia con monodroga Gemcitab, se completa el esquema por 8 ciclos. No existió respuesta favorable por lo que se propone tratamiento de segunda línea de quimioterapia con Ifosfomida. Presenta metástasis en mama la misma que posterior a exámenes de imagen y patología se concluye que la paciente presenta metástasis de células escamosas de Ca (cáncer) de Cérvix a mama, 6 meses posterior al diagnóstico la paciente fallece. La metástasis en la mama de una neoplasia de otros órganos es muy raro cuya incidencia es muy baja y de pronóstico sombrío. Palabras claves: metástasis, células escamosas, cáncer de cérvix.

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Lambert-Eaton Myasthenic Syndrome Associated with Synchronous Double Cancer: A Combination of Small Cell Carcinoma of the Cervix and Breast Carcinoma

Cited by 6 publications

References 9 publications

<p>Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage</p>

<p>Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage</p>

Multiple synchronous primary malignant neoplasms: A case report and literature review

Squamous Cell Metastasis of Cancer from Cervix to Breast: A Case Report

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