Multiple synchronous primary malignant neoplasms: A case report and literature review

Hao, Linlin; Zhang, Lihui; Xu, Chuanjie; Jiang, Min; Zhu, Geyi; Guo, Jie

doi:10.3892/ol.2023.14014

Cited by 3 publications

(1 citation statement)

References 26 publications

(23 reference statements)

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“…Multiple primary malignant neoplasms (MPMNs) are multiple primary tumours that occur simultaneously or heterochronously at different sites in the same patient and may occur throughout the body. 1 For the diagnosis of multiple primary tumours, it is very easy to miss a diagnosis when the tumours occur at the same time, and it is easy to misdiagnose metastatic cancer when they occur at different times. The duodenum and jejunum are the most common sites for small bowel adenocarcinoma, whereas small bowel adenocarcinoma in the distal ileum is rare.…”

Section: Introductionmentioning

confidence: 99%

Synchronous Multiple Primary Malignant Adenocarcinoma of the Descending Colon and Fungating Bleeding Adenocarcinoma of the Terminal Ileum Presenting Massive Rectal Bleeding: A Trap for the Unwary

Li,

Chen,

Wang

et al. 2024

OTT

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Primary cancer of the ileum is rare, and when it occurs in conjunction with primary colon cancer, it becomes even more infrequent and challenging to diagnose prior to surgical intervention. Primary small bowel cancers can be overlooked and may be misidentified as small bowel mesenchymal tumours or advanced metastases from colon cancer. We present an exceedingly uncommon case of ruptured primary ileal cancer combined with primary descending colon cancer presenting with gastrointestinal bleeding. Based on our understanding, instances of dual tumours concurrently occurring are exceedingly infrequent. In this patient, there was a preoperative suspicion of bleeding from colon cancer in the descending region. However, intraoperative exploration revealed that the location of the bleeding was a terminal ileal mass. Following the surgical intervention, the patient recovered satisfactorily. Intraoperative exploration of the entire gastrointestinal tract is therefore necessary in patients with gastrointestinal haemorrhage, especially in those who require urgent surgery without adequate preoperative investigations. If a mass is detected at the end of the ileum, intraoperative pathology should be performed if feasible. Subsequently, if the diagnosis reveals an adenocarcinoma, terminal ileocolic resection and right hemicolectomy are necessary for appropriate resection.

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Section: Introductionmentioning

confidence: 99%

Synchronous Multiple Primary Malignant Adenocarcinoma of the Descending Colon and Fungating Bleeding Adenocarcinoma of the Terminal Ileum Presenting Massive Rectal Bleeding: A Trap for the Unwary

Li,

Chen,

Wang

et al. 2024

OTT

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Multiple primary malignancies: sequential development of Ewing sarcoma and carcinoid tumor in a single patient

Ali,

Adhikari,

Noor

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction and importance: Multiple primary malignancies (MPMs) involve two or more distinct primary cancers in one individual, either simultaneously or at different times. The incidence of MPMs is rising due to advancements in cancer detection, improved survival rates, and long-term treatment effects. This case report, likely the first of its kind, highlights a rare instance of a 30-year-old female developing a carcinoid tumor 5 years after Ewing sarcoma, emphasizing the need for vigilant monitoring of cancer survivors. Case presentation: A 30-year-old female with a history of Ewing Sarcoma diagnosed 5 years prior, initially presenting with a vascular, hard mass on her right shoulder, underwent neoadjuvant chemotherapy and surgical excision. She recently presented with high-grade fever, cough, weight loss, and severe chest pain. Imaging and biopsy confirmed a high-grade carcinoid tumor. Histopathology showed positive markers for Synaptophysin, CD56, and Chromogranin, with a Ki-67 index of 30–40%. The patient passed away after one cycle of chemotherapy. Clinical discussion: Diagnosing and managing MPMs is challenging due to the complexity of distinguishing primary tumors from metastases. This case fits the Warren and Gates’ criteria for MPMs. This case confirmed Ewing sarcoma and atypical carcinoid tumor as distinct primary malignancies. Delayed diagnosis worsens outcomes, especially for aggressive atypical carcinoids. This case underscores the importance of thorough diagnostics, long-term follow-up, and improved healthcare infrastructure. Conclusion: This case report emphasizes the importance of a multidisciplinary approach, regular follow-ups, and timely detection for effective management of MPMs.

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Parallel Battles: Managing Synchronous Cervical and Triple-Negative Breast Cancers

Kouhen,

Chahid,

El Mjabber

et al. 2024

Cureus

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Multiple synchronous primary malignant neoplasms: A case report and literature review

Cited by 3 publications

References 26 publications

Synchronous Multiple Primary Malignant Adenocarcinoma of the Descending Colon and Fungating Bleeding Adenocarcinoma of the Terminal Ileum Presenting Massive Rectal Bleeding: A Trap for the Unwary

Synchronous Multiple Primary Malignant Adenocarcinoma of the Descending Colon and Fungating Bleeding Adenocarcinoma of the Terminal Ileum Presenting Massive Rectal Bleeding: A Trap for the Unwary

Multiple primary malignancies: sequential development of Ewing sarcoma and carcinoid tumor in a single patient

Parallel Battles: Managing Synchronous Cervical and Triple-Negative Breast Cancers

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