LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum

Alshehri, Samah; Malatani, Rania T.; Bogari, Hanin A.; Noor, Adeeb; Ibrahim, Amany K.; Elhady, Sameh S.; Abdelhameed, Reda F. A.

doi:10.3390/metabo10020075

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…221) and citromycetin derivative 581 . 222 Penicillium chrysogenum was the source of meroterpenoid 582 , 223 erythritol derivatives 583 and 584 , 223 cerebroside 585 , 224 dione 586 and dihydrothiophenone derivative 587 , 225 pentaketide derivative 588 and hydroxyphenylacetic acid derivatives 589 and 590 (ref. 226) and sorbicillinoids 591 and 592 .…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

et al. 2022

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Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

et al. 2022

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“…81 possesses a rare naphtho[2,1-b]pyrano-[3,2-e]pyran moiety. P. chrysogenum strain S003, a fungus isolated from Red Sea deep sediment, yielded two cytotoxic steroids 82 and 83 (Alshehri et al, 2020). 82 and 83 show cytotoxic effects against A-549, DU-145, MCF-7, and HepG2 cell lines, with IC 50 values ranging from 1.5 to 21.26 mM.…”

Section: Terpenoids and Steroidsmentioning

confidence: 99%

Deep-Sea-Derived Fungi as Valuable Producers of Cytotoxic Secondary Metabolites and Their Leads Potential

Zhao

Tang²,

Zhang³

et al. 2022

Front. Mar. Sci.

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Cancer is the leading lethal disease worldwide. Natural products have contributed significantly to the development of approved therapeutic agents. Therefore, research into new bioactive naturally sourced metabolites with lead potential is urgently needed. It is well-known that marine microorganisms are by far one of the most notable and prolific sources of bioactive natural products. Among them, deep-sea-derived fungi are extraordinarily adapted and metabolically active under extreme environmental conditions, which enable them to produce a large number of novel secondary metabolites. Chemical examination of deep-sea-derived fungi has yielded enormous amounts of cytotoxic natural products and potential drug leads. This review summarizes a total of 229 cytotoxic compounds isolated from deep-sea-derived fungi from 2010 to 2021. The emphasis is on the unique chemical diversity of these metabolic products, together with their relevant cytotoxic properties. Among the isolated metabolites, 82 compounds have been found to possess moderate to potent cytotoxic activities. Meanwhile, we also highlight some compounds with potent cytotoxicities (namely “star molecules”) considering their high drug lead potential. This review reveals deep-sea-derived fungi as considerable resources for the development of new drugs and the potential of the newly discovered secondary metabolites as valuable antitumor lead compounds.

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“…In a previous study by Alshehri et al ( 2020 ) stated that the chemical analysis of the P. chrysogenum S003 ethyl acetate extract yielded metabolites which were evaluated towards five human cancer cell lines by SRB assay. Ergosterol ( 187) and Epidioxyergosterol (194) showed promising cytotoxic activities against prostate (DU-145), hepatocellular (HepG2) cell lines, lung (A-549), and breast adenocarcinoma (MCF-7), with IC 50 values of 1.50, 6.10; 2.89, 3.07 21.26, 19.3; and 16.95, 13.6; µM, respectively.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review on the medicinally valuable endosymbiotic fungi Penicillium chrysogenum

Shaaban,

Elnaggar,

Khalil

et al. 2023

Arch Microbiol

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Recently, it has been shown that metabolites derived from endosymbiotic fungi attracted high attention, since plenty of them have promising pharmaceutical applications. The variation of metabolic pathways in fungi is considered an optimistic source for lead compounds. Among these classes are terpenoids, alkaloids, polyketides, and steroids, which have proved several pharmacological activities, including antitumor, antimicrobial, anti-inflammatory, and antiviral actions. This review concludes the major isolated compounds from different strains of Penicillium chrysogenum during the period 2013–2023, together with their reported pharmacological activities. From literature surveys, 277 compounds have been identified from P. chrysogenum, which has been isolated as an endosymbiotic fungus from different host organisms, with specific attention paid to those showing marked biological activities that could be useful in the pharmaceutical industry in the future. This review represents documentation for a valuable reference for promising pharmaceutical applications or further needed studies on P. chrysogenum.

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LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum

Cited by 6 publications

References 45 publications

Marine natural products

Marine natural products

Deep-Sea-Derived Fungi as Valuable Producers of Cytotoxic Secondary Metabolites and Their Leads Potential

A comprehensive review on the medicinally valuable endosymbiotic fungi Penicillium chrysogenum

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