Lagerstroemia speciosa extract ameliorates oxidative stress in rats with diabetic nephropathy by inhibiting AGEs formation

Aljarba, Nada H.; Hasnain, Saquib; Alkahtane, Abdullah A.; Algamdy, Hamzah; Alkahtani, Saad

doi:10.1016/j.jksus.2021.101493

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…It has antidiabetic [ 17 ], antiobesity [ 18 ], α -glucosidase inhibitors [ 19 ], and anti-inflammatory properties [ 20 ]. Additionally, it also has effects against diabetic nephtopathy [ 21 ]. Since the antihypertensive activity of LS has not been reported, and no research have been done to date on the antihypertensive activity of LS.…”

Section: Introductionmentioning

confidence: 99%

Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation

Aleissa

Al-Zharani

Alneghery

et al. 2022

BioMed Research International

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Cardiovascular disease is the primary reason for chronic heart diseases and mortality worldwide. Hypertension (HTN) is the utmost dominant risk factor for the evolution of several diseases. Herbal medicines, traditional medicinal herbs, and their extracts are widely utilized to treat and monitor HTN. Herbal components have been shown to help relax arteries and lower oxidative stress. The current study assesses the probable role of herbal plant extract Lagerstroemia speciosa (LS) in the LNAME induced HTN in rats. LNAME (50 mg/100 mL) in drinkable water was given to rats for five weeks. There was a significant upsurge in LNAME-treated hypertensive rats’ blood pressure (BP). On treatment with LS, it ameliorates blood pressure. Further, LS also improved body weight, reduced heart weight, and heart hypertrophy. The NO/cGMP concentration was lowered along with a substantial upsurge in the level of glutathione and a decline in MDA level. The LS extract also reduced the inflammatory cytokine markers in the systemic circulation. In conclusion, thus, the extract of LS treatment can efficiently alleviate the BP, oxidative stress markers, and inflammation and improve NO/cGMP concentration in LNAME induced HTN in rats.

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Section: Introductionmentioning

confidence: 99%

Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation

Aleissa

Al-Zharani

Alneghery

et al. 2022

BioMed Research International

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“…This has become a huge problem in the process of human history and global public health. At present, a large part of these diseases can be prevented and adjusted to relieve symptoms but cannot be completely cured at present medical methods (Aljarba et al, 2021). Many critically ill patients could maintain their vital signs and extend their lives through taking large amounts of drugs every day or relying on hospital rescue equipment.…”

Section: Application Of C Elegans Model To Evaluate Nutrition Of Acti...mentioning

confidence: 99%

Application of Caenorhabditis elegans in the evaluation of food nutrition: A review

Xiao

et al. 2023

eFood

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At present, more and more people are suffering from various diseases and it is particularly important to find a suitable biological model to evaluate the prevention and treatment effects of various drugs and active ingredients on diseases. In all biological models, Caenorhabditis elegans is a kind of organism that is easy to observe and cultivate, has a clear genetic background and a high degree of signal pathway conservation with humans. A variety of active ingredients such as polyphenols, polysaccharides, polypeptides, and vitamins exist from natural products, which has extremely high physiological functions and medicinal values. It is highly reliable to evaluate the trophic and functional properties of the active ingredients from natural products in C. elegans. The functional properties of the active ingredients from natural products such as antiaging, anti-oxidation, regulating lipid metabolism, preventing and treating Alzheimer's disease in C. elegans were clarified in this review. At the same time, its possible pathways were summarized. The literature revealed that it had great effect to evaluate the nutrition and functionality of the active ingredients from natural products in C. elegans. Finally, the shortcomings in this field and suggestions for further improvement in this field have been emphasized.

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“…Gutierrez and Ortiz [ 148 ] confirmed that the administration of Azadirachta indica chloroform extract (200 mg/kg orally per day for 30 days) to diabetic Wistar rats induced by STZ (50 mg/kg) inhibited the formation of AGEs. Other studies on the inhibition of AGE formation in diabetic rat models administered the following treatments: methanol extract of Punica granatum leaves (100 mg/kg, 200 mg/kg, and 400 mg/kg orally per day for 56 days) to diabetic Sprague–Dawley rats induced by 45 mg/kg of STZ [ 151 ]; hydroethanolic (80%) extract of Allium cepa bulbs (150 mg/kg and 300 mg/kg orally per day for 28 days) to diabetic Wistar rats induced by 50 mg/kg of STZ [ 155 ]; petroleum ether extract of Coriandrum sativum seeds (100 mg/kg, 200 mg/kg, and 400 mg/kg orally per day for 45 days) to diabetic Wistar rats induced by 65 mg/kg of STZ and 230 mg/kg of nicotinamide [ 16 ]; and Lagerstroemia speciosa leaf extract (400 mg/kg orally per day for 40 days) to diabetic Wistar rats induced by HFD and 35 mg/kg of STZ [ 163 ].…”

Section: Renoprotective Mechanisms Of Medicinal Plantsmentioning

confidence: 99%

A Review of Medicinal Plants with Renoprotective Activity in Diabetic Nephropathy Animal Models

Putra

Fakhrudin

Nurrochmad

et al. 2023

Life

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Diabetic nephropathy (DN), also recognized as diabetic kidney disease, is a kidney malfunction caused by diabetes mellitus. A possible contributing factor to the onset of DN is hyperglycemia. Poorly regulated hyperglycemia can damage blood vessel clusters in the kidneys, leading to kidney damage. Its treatment is difficult and expensive because its causes are extremely complex and poorly understood. Extracts from medicinal plants can be an alternative treatment for DN. The bioactive content in medicinal plants inhibits the progression of DN. This work explores the renoprotective activity and possible mechanisms of various medicinal plant extracts administered to diabetic animal models. Research articles published from 2011 to 2022 were gathered from several databases including PubMed, Scopus, ProQuest, and ScienceDirect to ensure up-to-date findings. Results showed that medicinal plant extracts ameliorated the progression of DN via the reduction in oxidative stress and suppression of inflammation, advanced glycation end-product formation, cell apoptosis, and tissue injury-related protein expression.

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Lagerstroemia speciosa extract ameliorates oxidative stress in rats with diabetic nephropathy by inhibiting AGEs formation

Cited by 4 publications

References 42 publications

Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation

Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation

Application of Caenorhabditis elegans in the evaluation of food nutrition: A review

A Review of Medicinal Plants with Renoprotective Activity in Diabetic Nephropathy Animal Models

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