Lactulose: An indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production

Chen, Xiao; Zuo, Qiao; Hai, Yuedong; Sun, Xuejun

doi:10.1016/j.mehy.2010.09.026

Cited by 62 publications

(42 citation statements)

References 25 publications

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“…It has been reported that lactulose has prebiotic, antioxidant and anti-inflammatory properties which may ameliorate colonic inflammation [9,10]. These studies were in agreement with the results of the present work where administration of lactulose to rats resulted in significant increase in tissue GSH with significant decrease in DAI, tissue TNF-α, MDA, NO, MPO and the histological disease score compared to TNBS-treated group.…”

supporting

confidence: 93%

“…It is digested by bacteria colonizing within the gastrointestinal tract, especially in the colon. Lactulose may be a novel and promising therapeutic option for colitis, possibly due to alterations of colonic microflora which are responsible for colonic inflammation [10]. Also, oral administration of lactulose significantly increased H 2 production which may has antioxidant and anti-inflammatory properties in the gastrointestinal tract [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies point to an over stimulation or inadequate regulation of the mucosal immune system as a major pathophysiologic pathway of colitis and particular emphasis has been given to the study of mucosal inflammation or immunologic reactions [10,24]. When the disease is active, the lamina propria of the mucosa becomes heavily infiltrated with inflammatory cells with increased mucosal IgG production, evidence of complement activation and activation of macrophages and T cells.…”

mentioning

confidence: 99%

“…Moreover, H 2 mediates suppression of proinflammatory cytokines, especially TNF-α and IL-6 in the inflammed tissues. As a novel antioxidant, H 2 can easily penetrate biomembranes and diffuse into the cytosol, mitochondria and nucleus without affecting the normal intestinal flora [10].…”

mentioning

confidence: 99%

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Ameliorative Potential of Minocycline and/or Lactulose on Experimentally Induced Colitis

Kabel

2016

IJPPE

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Abstract.Objective: The aim of this study was to compare between the effect of minocycline or lactulose alone and in combination on experimentally-induced colitis in rats. Materials and methods: Seventy albino rats were divided into 7 equal groups: Control untreated group, trinitrobenzenesulphonic acid (TNBS) group, TNBS + lactulose group, lactulose group, TNBS + minocycline group, minocycline group and TNBS + lactulose+ minocycline group.

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supporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Ameliorative Potential of Minocycline and/or Lactulose on Experimentally Induced Colitis

Kabel

2016

IJPPE

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“…Hydrogen can selectively neutralize cytotoxic reactive oxygen species and protect cells from oxidative stress injuries (Chen, Zuo, Hai, & Sun, 2011). Previous study suggested that lactulose reduced oxidative stress by producing hydrogen (Ghanizadeh, 2012).…”

Section: Discussionmentioning

confidence: 99%

Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice

et al. 2018

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Gut microbiota have strong connections with health. Lactulose has been shown to regulate gut microbiota and benefit host health. In this study, the effect of short-term (3 week) intervention of lactulose on gut microbiota was investigated. Gut microbiota were detected from mouse feces by 16S rRNA high-throughput sequencing, and short chain fatty acids (SCFAs) were detected by gas chromatography-mass spectrometry (GC-MS). Lactulose intervention enhanced the α-diversity of the gut microbiota; increased the abundance of hydrogen-producing bacteria Prevotellaceae and Rikenellaceae, probiotics Bifidobacteriaceae and Lactobacillaceae, and mucindegrading bacteria Akkermansia and Helicobacter; decreased the abundance of harmful bacteria Desulfovibrionaceae and branched-chain SCFAs (BCFAs). These results suggest that lactulose intervention effectively increased the diversity and improved the structure of the intestinal microbiota, which may be beneficial for host health. K E Y W O R D S16S rRNA high-throughput sequencing, gut microbiota, prebiotic, probiotics, short chain fatty acids 2 of 8 | ZHAI et Al. enzymes in the intestine, but is metabolized by gut microbiota to short chain fatty acids (SCFAs) in the ileum (Guerra-Ordaz et al., 2014).Lactulose can change the composition of the gut microbiota. For example, Vanhoutte et al. (2006), reported a significant increase in Bifidobacterium adolescentis following lactulose intake. Tuohy et al. (2002) showed that Bifidobacterium spp. were increased, whereas Clostridia and Lactobacilli were decreased after lactulose treatment in humans.SCFAs are main metabolites of gut microbiota, and are divided into straight-chain SCFAs and branched-chain SCFAs (BCFAs). Straightchain SCFAs are mainly produced by microbial fermentation of unabsorbed dietary carbohydrates in the gut. Lactate and succinate can also be metabolized to straight-chain SCFAs, including acetate, propionate, and butyrate (Hasebe et al., 2016;Verbeke et al., 2015). Straight-chain SCFAs have a range of beneficial effects, including regulation of the colonic and intracellular environment (Wong et al. 2006), and modulation of cell proliferation and gene expression. In addition, straightchain SCFAs are able to improve immune function, glucose regulation, and prevent obesity (Polyviou et al., 2016). In contrast, BCFAs are always derived from catabolism of branched-chain amino acids (Zheng et al., 2013), and are major markers of protein fermentation, which is likely to be detrimental to the host (Yang & Rose, 2015).Although some studies have assessed the effects of lactulose on gut microbiota, the gel-or PCR-based methods used limit our ability to evaluate the full extent of the impact of lactulose on the gut microbiotic community. In this study, 16S rRNA high-throughput sequencing and gas chromatography-mass spectrometry (GC-MS) were used to evaluate effect of lactulose on gut microbiota and their metabolites in mice. | MATERIAL S AND ME THODS | Animals and experiment designSix-week-old male C57BL/6J mice were...

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Lactulose

Kumari

Panesar

Panwar

et al. 2022

Probiotics, Prebiotics and Synbiotics

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Lactulose: An indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production

Cited by 62 publications

References 25 publications

Ameliorative Potential of Minocycline and/or Lactulose on Experimentally Induced Colitis

Ameliorative Potential of Minocycline and/or Lactulose on Experimentally Induced Colitis

Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice

Lactulose

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