Lactosucrose production using a simulated moving bed reactor

Novel process for diethylacetal synthesis

“…Examples of biochemical reactions are the isomerization of glucose with glucose isomerase, [24][25][26][27] the inversion of sucrose by action of invertase, 28,29 and the production of lactosucrose by action of b-fructofuranosidase. 30 Examples of reversible chemical reactions catalyzed by ion-exchange resins are the esterification of acetic acid with b-phenetyl alcohol, 31 the ethyl acetate synthesis on Amberlyst ® 15, 9,32 the synthesis of bisphenol A from acetone and phenol, 33 esterification of acetic acid with methanol, 34 and synthesis of MTBE. 35 Another example is the dismutation of toluene into benzene and xylenes.…”

“…The effect of the feed concentration onto the qualitative shape of the reaction/separation region was studied for the system of methyl acetate production, considering the equilibrium theory model for the SMBR with infinitely fast reaction rate (instantaneous reaction equilibrium). 51 In Figure 20 the optimal operating points (the vertices of the reaction/separation regions) for the other six different feed molar fractions of acetaldehyde (10,20,30,40,60, and 80%) are indicated with gray circles. By increasing the distance from the diagonal of the ␥ II -␥ III plane, the feed flow rate is increased.…”

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

“…This intensified reaction-separation technology adopts the name simulated moving bed reactor (SMBR). A considerable number of applications have been reported considering SMBRs, among others: enzymatic reaction for higher-fructose syrup production [137][138][139][140], intensified synthesis of fructooligosaccharides [12], esterification from acetic acid and b-phenethyl alcohol to produce b-phenethyl acetate [141] or methyl/ethyl acetate ester from methanol/ethanol [142][143][144], synthesis and separation of methanol from syngas [145], lactosucrose production [146], MTBE synthesis [147], diethylacetal (dimethylacetal) synthesis [148][149][150][151], ethyl lactate synthesis from lactic acid and ethanol [152], biodiesel synthesis [153,154], in situ isomerization and separation of p-xylene [155,156], and, more recently, in the production of single enantiomers [157]. These examples prove the potential of this technique.…”

Conceptual Design of Integrated Chromatographic Processes for the Production of Single (Stereo‐)Isomers

“…1, right) is a fully integrated SMB reactor where reaction and separation occur simultaneously throughout the unit. The approach was applied, for example, to esterifications [13][14][15][16] and different enzymatic productions [17,18]. As regards isomerization reactions, only a case with low purity requirements was studied [19].…”