Lactose tolerance test as an alternative to hydrogen breath test in the study of lactose malabsorption

Sendino, Teresa; Sandúa, Amaia; Calleja, Sofía; González, Ana Marta; Alegre, Estíbaliz

doi:10.1515/almed-2020-0102

Cited by 3 publications

(2 citation statements)

References 22 publications

(35 reference statements)

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“…Sendiny et al (2020) studied lactose malabsorption in patients that had not undergone bariatric treatments. They found that 26.7% of 430 patients had positive results for lactose malabsorption [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Breath Tests Used in the Context of Bariatric Surgery

et al. 2022

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This review article focuses on the use of breath tests in the field of bariatrics and obesitology. The first part of the review is an introduction to breath test problematics with a focus on their use in bariatrics. The second part provides a brief history of breath testing. Part three describes how breath tests are used for monitoring certain processes in various organs and various substances in exhaled air and how the results are analyzed and evaluated. The last part covers studies that described the use of breath tests for monitoring patients that underwent bariatric treatments. Although the number of relevant studies is small, this review could promote the future use of breath testing in the context of bariatric treatments.

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Section: Discussionmentioning

confidence: 99%

Breath Tests Used in the Context of Bariatric Surgery

et al. 2022

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“…To avoid false negative results, H 2 /CH 4 baseline levels should be low 5 , 6 and interpretation of elevated baseline levels is still uncertain 7 . We have previously shown that baseline high H 2 levels are associated with more positive lactose breath test 8 . For this reason, patient preparation is required 7 , 9 , and it includes avoiding drugs such as antibiotic or laxatives, in the previous days, or procedures that could alter colonic microbiota such as colonoscopy.…”

Section: Introductionmentioning

confidence: 93%

Modification of baseline status to improve breath tests performance

Alegre

Sandúa

Calleja

et al. 2022

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Breath tests used to evaluate carbohydrates malabsorption require baseline H2 and CH4 levels as low as possible. Test cancellation is recommended when exceeding certain cut-offs (H2 ≥ 20 ppm and CH4 ≥ 10 ppm). Although following preparation protocols, many patients have baseline levels above those cut-offs. We investigated if light walking can reduce baseline H2 and CH4 levels. We retrospectively analyzed baseline H2 and CH4 levels from 1552 breath tests. Baseline levels (B1), especially in H2, were lower when obtained at later hours of the day. In those with baseline levels above cut-off, re-sampling (B2) after light walking for one hour, decreased H2 levels 8 ppm (Q1–Q3: 1–18 ppm), and 2 ppm (Q1–Q3: 0–3 ppm) for CH4. Consequently, 40% of tests with elevated B1 levels, presented B2 levels below mentioned cut-offs. Ten percent of tests considered negative when using B1 for calculations, turned positive when using B2 instead. All positive tests when using B1 values, remained elevated when using B2. Re-sampling after light walking for one hour could allow test performance in those with previous elevated baseline levels, avoiding diagnosis delays. Using the second sample for delta calculations identifies positive patients for malabsorption that would have been considered negative.

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Cow’s milk-induced gastrointestinal disorders: From infancy to adulthood

Al‐Biltagi¹,

Saeed²,

Bediwy³

et al. 2022

World J Clin Pediatr

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Milk is related to many gastrointestinal disorders from the cradle to the grave due to the many milk ingredients that can trigger gastrointestinal discomfort and disorders. Cow’s milk protein allergy (CMPA) is the most common food allergy, especially in infancy and childhood, which may persist into adulthood. There are three main types of CMPA; immunoglobulin E (IgE)-mediated CMPA, non-IgE-mediated CMPA, and mixed type. CMPA appears before the first birthday in almost all cases. Symptoms may start even during the neonatal period and can be severe enough to simulate neonatal sepsis. CMPA (often non-IgE mediated) can present with symptoms of gastroesophageal reflux, eosinophilic esophagitis, hemorrhagic gastritis, food protein-induced protein-losing enteropathy, and food protein-induced enterocolitis syndrome. Most CMPAs are benign and outgrown during childhood. CMPA is not as common in adults as in children, but when present, it is usually severe with a protracted course. Lactose intolerance is a prevalent condition characterized by the development of many symptoms related to the consumption of foods containing lactose. Lactose intolerance has four typical types: Developmental, congenital, primary, and secondary. Lactose intolerance and CMPA may be the underlying pathophysiologic mechanisms for many functional gastrointestinal disorders in children and adults. They are also common in inflammatory bowel diseases. Milk consumption may have preventive or promoter effects on cancer development. Milk may also become a source of microbial infection in humans, causing a wide array of diseases, and may help increase the prevalence of antimicrobial resistance. This editorial summarizes the common milk-related disorders and their symptoms from childhood to adulthood.

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Lactose tolerance test as an alternative to hydrogen breath test in the study of lactose malabsorption

Cited by 3 publications

References 22 publications

Breath Tests Used in the Context of Bariatric Surgery

Breath Tests Used in the Context of Bariatric Surgery

Modification of baseline status to improve breath tests performance

Cow’s milk-induced gastrointestinal disorders: From infancy to adulthood

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