Lactose Tolerance in Relation to Intestinal Lactase Activity

Peternel, Wayne W.

doi:10.1016/s0016-5085(65)80107-x

Cited by 54 publications

(7 citation statements)

References 24 publications

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“…Enzyme studies of intestinal biopsy specimens proved the absence of lactase activity in an otherwise morphologically normal mucosa. These observations have been confirmed by Cuatrecasas, Lockwood, and Caldwell (1965), Dunphy, Littman, Hammond, Forstner, Dahlqvist, and Crane (1965), Peternel (1965), andMcMichael, Webb, andDawson (1965).…”

Section: Sugar Transportsupporting

confidence: 53%

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Sugar malabsorption due to deficiencies of disaccharidase activities and of monosaccharide transport.

Holzel¹

1967

Archives of Disease in Childhood

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In many societies including our own, carbohydrates play a major part in the total calorie supply. According to the National Food survey figures (Greaves and Hollingsworth, 1964), the average daily diet of adults contains nearly 350 g. of this constituent. Diets of course vary with eating habits and social class, but the dietary carbohydrates are largely ingested as poly-, oligo-, and disaccharides. In the very young, however, the carbohydrate intake may consist almost entirely of disaccharides, though this phase is now getting progressively shorter. As the rapid decrease in breast-feeding has been followed by the early introduction of cereals into the cow's milk formulae, even the infant of only a few weeks of age has also to digest polysaccharides. Sjovall, 1957; Dahlqvist and Borgstrom, 1961) demonstrated that disaccharidase activity in the intestinal lumen was extremely limited and did not account for the amount of carbohydrate absorbed. They further indicated that the majority of disaccharides were absorbed unhydrolysed and split intracellularly, a fact that accorded well with experimental findings (Cajori, 1933;Fridhandler and Quastel, 1955).The problem of localization of the sugar-splitting enzymes was brought nearer its solution by Miller and Crane (1961), who were able to separate the brush-border from the rest of the intestinal mucosa of the hamster, and found that the whole of the enzyme activity of the mucosa was accounted for by this layer. (-galactosidase (lactase) activity had been localized in the microsomes of the rat intestinal mucosa by Doell and Kretchmer (1962), while Dahlqvist and Brun (1962), employing histochemical methods for the recognition of invertase and trehalase in various animal tissues, associated their activity with cytoplasmic granules. As yet there is no definite information concerning the possible relationship of the elements of fine structure of the microvillus with its absorptive and digestive functions. However, two related fractions have been obtained by density gradient centrifugation of tris-disrupted brush-borders from hamster intestinal mucosa, and have been identified as the microvillus cores and their surrounding membranous coats (Overton, Eichholz, and Crane, 1965;Eichholz and Crane, 1965).

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Section: Sugar Transportsupporting

confidence: 53%

“…water in 30 minutes caused a normal rise of blood glucose. Peternel (1965), in evaluating the oral lactose tolerance test as a screening test, found a good correlation between an increase in blood glucose greater than 20 mg./100 ml. above the fasting level, with normal lactase activity.…”

Section: Sugar Transportmentioning

confidence: 99%

Sugar malabsorption due to deficiencies of disaccharidase activities and of monosaccharide transport.

Holzel¹

1967

Archives of Disease in Childhood

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“…In contrast, McMichael(l5) showed that in patients with normal lactase activity there was no correlation between lactase activity and maximum blood glucose increase after an oral load of lactose. However, several other studies have shown a positive correlation between LTT and lactase activity in the human small intestine (16,17). The partial villus atrophy observed (18) is in accordance with these biochemical findings.…”

Section: Discussionsupporting

confidence: 88%

Effect of Mild Malnutrition on Disaccharidase Activity and Glucose Uptake in Intestinal Brush Border Vesicles of Growing Monkeys

Rana

Gupta

Vaiphei

et al. 1995

Scandinavian Journal of Gastroenterology

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“…The results of these tests correlate well with lactase activity (Cuatrecasas, Lockwood, and Caldwell, 1965;Haemmerli, Kistler, Ammann, Marthaler, Semenza, Auricchio, and Prader, 1965;Peternel, 1965;Sheehy and Anderson, 1965). Decreased intestinal lactase activity is practically always associated with a flat lactose, tolerance curve (maximum increase of blood glucose less Lactose Bariumn Meal (25g) Lactose malabsorption and postgastrectomy milk intolerance, dumping, and diarrhoea than 20 mg/100 ml and normal glucose and galactose tolerance curves) (Weser, Rubin, Ross, and Sleisenger, 1965;Welsh.…”

Section: Discussionmentioning

confidence: 79%

Lactose malabsorption and postgastrectomy milk intolerance, dumping, and diarrhoea.

Condon¹,

Westerholm²,

Tanner³

1969

Gut

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Lactose Tolerance in Relation to Intestinal Lactase Activity

Cited by 54 publications

References 24 publications

Sugar malabsorption due to deficiencies of disaccharidase activities and of monosaccharide transport.

Sugar malabsorption due to deficiencies of disaccharidase activities and of monosaccharide transport.

Effect of Mild Malnutrition on Disaccharidase Activity and Glucose Uptake in Intestinal Brush Border Vesicles of Growing Monkeys

Lactose malabsorption and postgastrectomy milk intolerance, dumping, and diarrhoea.

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