Lactose Biosensor Development and Deployment in Dairy Product Analysis

Halpin, Grace; McEntee, Sinead; Dwyer, Catherine M; Lawless, Fergal; Dempsey, Eithne

doi:10.1149/1945-7111/ac5e41

Cited by 10 publications

(1 citation statement)

References 41 publications

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“…The fabricated galactose biosensor presented a linear response in blood serum from 0.05–0.5 g galactose L −1 . Moreover, some recently developed biosensors are also reported for electrochemical detection of lactose [ 68 , 69 ].…”

Section: Nanomaterial-based Biosensors For Metabolites Detectionmentioning

confidence: 99%

Nanomaterial-Based Electrochemical Nanodiagnostics for Human and Gut Metabolites Diagnostics: Recent Advances and Challenges

et al. 2022

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Metabolites are the intermediatory products of metabolic processes catalyzed by numerous enzymes found inside the cells. Detecting clinically relevant metabolites is important to understand their physiological and biological functions along with the evolving medical diagnostics. Rapid advances in detecting the tiny metabolites such as biomarkers that signify disease hallmarks have an immense need for high-performance identifying techniques. Low concentrations are found in biological fluids because the metabolites are difficult to dissolve in an aqueous medium. Therefore, the selective and sensitive study of metabolites as biomarkers in biological fluids is problematic. The different non-electrochemical and conventional methods need a long time of analysis, long sampling, high maintenance costs, and costly instrumentation. Hence, employing electrochemical techniques in clinical examination could efficiently meet the requirements of fully automated, inexpensive, specific, and quick means of biomarker detection. The electrochemical methods are broadly utilized in several emerging and established technologies, and electrochemical biosensors are employed to detect different metabolites. This review describes the advancement in electrochemical sensors developed for clinically associated human metabolites, including glucose, lactose, uric acid, urea, cholesterol, etc., and gut metabolites such as TMAO, TMA, and indole derivatives. Different sensing techniques are evaluated for their potential to achieve relevant degrees of multiplexing, specificity, and sensitivity limits. Moreover, we have also focused on the opportunities and remaining challenges for integrating the electrochemical sensor into the point-of-care (POC) devices.

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Section: Nanomaterial-based Biosensors For Metabolites Detectionmentioning

confidence: 99%

Nanomaterial-Based Electrochemical Nanodiagnostics for Human and Gut Metabolites Diagnostics: Recent Advances and Challenges

et al. 2022

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Exploitation of carbon surface functionality toward additive‐free formation of gold nanocuboids suitable for sensitive assay of N‐acetylcysteine in pharmaceutical formulations

Murphy,

Guin,

Lapiy

et al. 2024

Electrochemical Science Adv

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Chemical additive and physical template‐free electrochemical methods to prepare carbon‐supported nanostructures of catalyst metals represent an emerging technology. Formation of the metal nano/microstructures depends not only on the electrochemical method/parameters but also on the nature of the underlying carbon material. Here, we present a comparative evolution of unevenly distributed coral‐like aggregates of nanocuboid‐shaped gold nanostructures (AuNCBs) on the oxidised form of boron, nitrogen‐doped carbon nanoonions (oxi‐B,N‐CNO) compared to evenly distributed bud‐like aggregates of cubic shaped gold nanostructures on bare glassy carbon electrode under a similar electrochemical approach. The synthesis method provided the best availability of the surface active sites, whereas the shape of the structures showed a direct influence of both outer‐sphere and inner‐sphere electron transfer reactions. The higher sensitivity of AuNCBs@oxi‐B,N‐CNO compared to individual components and bare carbon/gold electrodes toward the inner‐sphere oxidative reaction of N‐acetyl‐L‐cysteine (NAC) was exploited in order to develop an electrochemical assay method with sensitivity and linear dynamic range of (4.70 ± 0.25) × 10−4 C∙cm−2∙mM−1 and 0.2–2.5 mM, respectively in acetate buffer (pH 4.45). Furthermore, the sensor design was deployed in the quantitation of NAC in pharmaceutical preparations, resulting in 89%–106% recovery.

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Electrochemical sensor based on ionic liquid for detection of lactose content in dairy products

2023

Food Measure

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Lactose Biosensor Development and Deployment in Dairy Product Analysis

Cited by 10 publications

References 41 publications

Nanomaterial-Based Electrochemical Nanodiagnostics for Human and Gut Metabolites Diagnostics: Recent Advances and Challenges

Nanomaterial-Based Electrochemical Nanodiagnostics for Human and Gut Metabolites Diagnostics: Recent Advances and Challenges

Exploitation of carbon surface functionality toward additive‐free formation of gold nanocuboids suitable for sensitive assay of N‐acetylcysteine in pharmaceutical formulations

Electrochemical sensor based on ionic liquid for detection of lactose content in dairy products

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