Lactose

Holsinger, V.H.

doi:10.1007/978-1-4615-7050-9_6

Cited by 34 publications

(27 citation statements)

References 124 publications

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“…Therefore, the speed of sonicated molecules will be fast enough to approach each side of the crystal in comparison with the growth rate in the conventional crystallization [18]. In an earlier study [20] with acetone to recover lactose from whey, acetone was added to concentrated whey (18 to 20% lactose) up to 65%, which allowed recovery of 85% of lactose in 3.5 hours period. The yield of lactose and rapidity of crystallization were influenced by the rate of acetone addition [20].…”

Section: Resultsmentioning

confidence: 99%

“…In an earlier study [20] with acetone to recover lactose from whey, acetone was added to concentrated whey (18 to 20% lactose) up to 65%, which allowed recovery of 85% of lactose in 3.5 hours period. The yield of lactose and rapidity of crystallization were influenced by the rate of acetone addition [20]. Another study of lactose crystallization in water-acetone solutions, lactose yield was found to be 92.63% from 27.02 (g/100 g solvent) reconstituted lactose solution during 2.9 h period, stirred at 350 rpm [9].…”

Section: Resultsmentioning

confidence: 99%

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Ultrasound assisted crystallization for the recovery of lactose in an anti‐solvent acetone

Patel

Murthy²

2009

Cryst. Res. Technol.

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Continuous worldwide increase in high-scale production of dairy products leads to the constant generation of vast amounts of liquid by-product, whey. Disposal of liquid whey is costly due to its high biological oxygen demand (BOD) and water content. More than 90% of whey BOD is due to lactose. Recovery of lactose from whey solves both the problems of improving economics of whey utilization and pollution reduction as lactose recovery itself can reduce BOD of whey by more then 80%. Commercial effluent treatment techniques focus on degradation rather than recovery of useful by-products like lactose. Also, these techniques are time consuming and hence not effective enough. Sonocrystallization is the use of power ultrasound to control the crystallization process during the nucleation phase. In the present study, the process of lactose crystallization has been studied for the recovery of lactose from reconstituted lactose solutions with the aid of ultrasound, in the presence of 'acetone', as an anti-solvent. The crystallization is found to be completed with excellent yields in the range of 80 -92% within 4 minutes of sonication.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Ultrasound assisted crystallization for the recovery of lactose in an anti‐solvent acetone

Patel

Murthy²

2009

Cryst. Res. Technol.

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“…On the other hand, no variations confirming chemical interactions were found in the IR spectra and XRPD diffraction patterns of these mixtures. A detailed inspection of the thermal events due to the melting of hydrocortisone (216°C [23], 214°C [24] or 221.5°C [25]) and of anhydrous a-lactose (222.8°C [26], 223°C [27][28][29]) suggests that both endothermic peaks are superimposed excluding incompatibility.…”

Section: Dsc Ir and Xrdp For Verification Of Resultsmentioning

confidence: 99%

Compatibility studies of hydrocortisone with excipients using thermogravimetric analysis supported by multivariate statistical analysis

Rojek

Wesołowski

2016

J Therm Anal Calorim

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Application of thermogravimetry (TG) alone to study compatibility/incompatibility of active pharmaceutical ingredients (APIs) with excipients yields to misleading results due to overlapping of the thermal stages in the course of decomposition of both ingredients and their pharmaceutical mixtures. Hence, the purpose of this study was to assess the usefulness of multivariate statistical analysis as a supporting tool for interpretation of the TG traces during assessing compatibility of hydrocortisone as an API with selected excipients (mannitol, starch, lactose, methylcellulose, b-cyclodextrin, meglumine, chitosan, magnesium stearate and polyvinylpyrrolidone). The results show that two multivariate techniques, principal component analysis (PCA) and cluster analysis (CA), can be successfully used for interpretation of TG traces, while the TG is used alone as a screening technique to assess compatibility. The results obtained by using TG analysis, supported by PCA and CA, were approved by those of differential scanning calorimetry, infrared spectroscopy and X-ray powder diffraction. Incompatibilities were only found in mixtures of hydrocortisone with magnesium stearate and b-cyclodextrin.

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“…When used as excipient in drugs, lactose is the substance where the active ingredient is dispersed and preserved in a stable state [4,5]. This disaccharide exists in two isomeric forms, -lactose, and -lactose, which shows the phenomenon of mutarotation, that is, the interconversion of the stereocenters [6]. Lactose exhibits three polymorphs (anhydrous forms) and a solvate (hydrated form): anhydrous -lactose ( L), Crystalline L, purity of 95%.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of High Purity Anhydrous β-Lactose from α-Lactose Monohydrate at Mild Temperature

López-Pablos

Leyva‐Porras

Silva-Cázares

et al. 2018

International Journal of Polymer Science

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Lactose is a disaccharide of importance in humans dietary, food products, and the pharmaceutical industry. From the existing isomeric forms, -lactose is rarely found in nature. Thus, in this work, a simple methodology to obtain anhydrous -lactose ( L) from -lactose monohydrate ( L⋅H 2 O) is presented. The L⋅H 2 O powder was dispersed into a basic alcoholic solution (72 hours), at controlled conditions of temperature (27, 29, 31, and 32 ∘ C), without stirring. The slurry was dried at room temperature and characterized. Fourier transform infrared spectroscopy showed the formation of L for the samples prepared at 29 and 32 ∘ C. Raman spectroscopy confirmed this result and suggested the occurrence of crystalline L. Rietveld refinement of the X-ray diffraction patterns was employed to identify and quantify the composition of the isomers. The samples prepared at 29 and 31 ∘ C showed the formation of pure L, while those at 27 and 32 ∘ C showed the presence of L⋅H 2 O and a mixture of the two isomers, respectively. The morphology of the powders was studied by scanning electron microscopy, observing the formation of irregular shape L⋅H 2 O particles and axe-like L particles. Clearly, with this methodology, it was possible to obtain pure, crystalline, and anhydrous L at mild temperature.

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Lactose

Cited by 34 publications

References 124 publications

Ultrasound assisted crystallization for the recovery of lactose in an anti‐solvent acetone

Ultrasound assisted crystallization for the recovery of lactose in an anti‐solvent acetone

Compatibility studies of hydrocortisone with excipients using thermogravimetric analysis supported by multivariate statistical analysis

Preparation and Characterization of High Purity Anhydrous β-Lactose from α-Lactose Monohydrate at Mild Temperature

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