Lactoferrin: structure, function and applications

González-Chávez, Susana Aideé; Arévalo-Gallegos, Sigifredo; Rascón-Cruz, Quintín

doi:10.1016/j.ijantimicag.2008.07.020

Cited by 526 publications

(448 citation statements)

References 93 publications

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“…18,21,23,75,93,125 There is also a decrease in the levels of several antioxidant or anti-inflammatory molecules: SOD, glutathione, lactoferrin, IgA, and IL-10. 19,20,106,[108][109][110]144 An important decrease in the level of protease inhibitors such as cystatins (inhibitors of cysteine proteases) and TIMP-1 (inhibitor of MMPs) have also been reported. 95,96,101,[129][130][131] The increased activity of several proteolytic enzymes results in higher concentrations of ROS, RNS, cytotoxic aldehydes (CAs) and peroxynitrates (Ps) (which decreases the activity of TIMP-1 and increase MMP-2), 63,143,144,146,149 and given the lower production of SOD 143 possibly related to IL-1α, 158 an environment with high oxidative stress and low pH is formed, causing an increase in the activation of the caspases (caspase-9 and -12), mitochondrial dysfunction (MD), and DNA damage, 156 which eventually lead to increased apoptosis.…”

Section: Resultsmentioning

confidence: 99%

“…19,108 Lactoferrin and IgA seem to have the greatest impact on the disease because of their immunomodulatory and antiinflammatory properties (lactoferrin inhibits IL-1, IL-2, IL-6, and TNF-α; IgA inhibits the immune response through FcαRI receptor). 109,110 In 1961, Ridley 115 related eye rubbing with keratoconus, and many researchers have later confirmed that finding. 72,111-118 Bawazeer et al 11 published the results of a case-control study, which showed, using multivariate analysis, that eye rubbing was a significant predictor of keratoconus.…”

Section: Corneal Stroma Compositionmentioning

confidence: 98%

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Keratoconus: an inflammatory disorder?

Galvis

Sherwin

Tello

et al. 2015

Eye

273

190

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Keratoconus has been classically defined as a progressive, non-inflammatory condition, which produces a thinning and steepening of the cornea. Its pathophysiological mechanisms have been investigated for a long time. Both genetic and environmental factors have been associated with the disease. Recent studies have shown a significant role of proteolytic enzymes, cytokines, and free radicals; therefore, although keratoconus does not meet all the classic criteria for an inflammatory disease, the lack of inflammation has been questioned. The majority of studies in the tears of patients with keratoconus have found increased levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase (MMP)-9. Eye rubbing, a proven risk factor for keratoconus, has been also shown recently to increase the tear levels of MMP-13, IL-6, and TNF-α. In the tear fluid of patients with ocular rosacea, IL-1α and MMP-9 have been reported to be significantly elevated, and cases of inferior corneal thinning, resembling keratoconus, have been reported. We performed a literature review of published biochemical changes in keratoconus that would support that this could be, at least in part, an inflammatory condition.

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Section: Resultsmentioning

confidence: 99%

Section: Corneal Stroma Compositionmentioning

confidence: 98%

Keratoconus: an inflammatory disorder?

Galvis

Sherwin

Tello

et al. 2015

Eye

273

190

View full text Add to dashboard Cite

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“…LF has been described as a multifunctional milk protein displaying a range of bioactivities. Intact and hydrolyzed lactoferrin have mainly been reported as antimicrobial [7,9,12,28,35,52], anti-inflammatory [14,28,36] opioid antagonist [12] and antioxidant agents [71]. Intact LF did not inhibit XO (Table 3).…”

Section: Discussionmentioning

confidence: 98%

Tryptophan-containing milk protein-derived dipeptides inhibit xanthine oxidase

2012

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“…Lactoferrin and Lf-derived peptides have been shown to inhibit viral 14 , fungal 15 , parasitic and bacterial infections [16][17][18] . The antibacterial activity of lactoferrin has been widely documented both in vitro and in vivo for Gram-positive and Gram-negative bacteria 19 . The mechanism against Gram-negative bacteria cons ists in the interaction with lipopolysaccharide (LPS).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

et al. 2015

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Dental implant failure can be associated to infections which develop into periimplantitis. In order to reduce biofilm formation, several strategies focusing on the use of antimicrobial peptides (AMP) have been studied. To covalently immobilize these molecules onto metallic substrates several techniques have been developed, including silanization and polymer brush prepared by surface-initiated atom transfer radical polymerization (ATRP), with varied peptide binding yield and antibacterial performance. The aim of the present study was to compare the efficiency of these methods to immobilize the lactoferrin-derived hLf1-11 antibacterial peptide onto titanium, and evaluate their antibacterial activity in vitro.Smooth titanium samples were coated with hLf1-11 peptide under three different conditions: silanization with APTES, and polymer brush based coatings with two different silanes. Peptide presence was determined by X-ray photoelectron spectroscopy and the mechanical stability of the coatings was studied under ultrasonication. The LDH assays confirmed that HFFs viability and proliferation were no affected by the treatments. The in vitro antibacterial properties of the modified surfaces were tested with two oral strains (Streptococcus sanguinis and Lactobacillus salivarius) showing an outstanding reduction. A higher decrease in bacterial attachment was noticed when samples were modified by ATRP methods compared to silanization. This effect is likely due to the capacity to immobilize more peptide on the surfaces using polymer brushes and the non-fouling nature of polymer PDMA segment.3

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Lactoferrin: structure, function and applications

Cited by 526 publications

References 93 publications

Keratoconus: an inflammatory disorder?

Keratoconus: an inflammatory disorder?

Tryptophan-containing milk protein-derived dipeptides inhibit xanthine oxidase

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

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