Lactoferrin is associated with a decrease in oocyte depletion in mice receiving cyclophosphamide

Horiuchi, Yuka; Higuchi, Toshihiro; Tatsumi, Kazuyoshi; Takakura, Kenji; Fujii, Shingo; Konishi, Ikuo

doi:10.1016/j.fertnstert.2008.07.024

Cited by 10 publications

(5 citation statements)

References 38 publications

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“…Irradiated mice on an LF diet exhibited a significantly higher survival rate compared with mice fed a standard diet (18). The prevention of chemotherapy-induced ovarian disorders in mice receiving oral LF has also been reported (19). In addition, the use of a gel containing LF in patients with oral cancer who were treated with radiotherapy, increased salivary secretion, inhibited xerostomia and improved oral bacterial flora (20).…”

Section: Introductionmentioning

confidence: 97%

Radioprotective effect of lactoferrin in mice exposed to sublethal X‑ray irradiation

Qin

et al. 2018

Exp Ther Med

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The radioprotective effect of lactoferrin (LF) was studied in mice subjected to sublethal X-ray irradiation. The mice were randomly divided into the Control (non-irradiated mice fed a standard diet without LF), IR (irradiated mice fed a standard diet) and IR+LF (irradiated mice fed LF) groups. The mice were fed daily for 7 days prior to irradiation and for 30 continuous days following irradiation. The survival ratio of the mice in the IR+LF group was significantly increased compared with the IR group between days 15 and 30 after irradiation. The body weight of the mice in the IR+LF group was increased compared with the IR group, and the difference was statistically significant. Blood was collected from the mice via the tail vein on days 2, 7, 14, 21 and 30 following irradiation. The laboratory indicators, including leukocyte, erythrocyte and platelet counts recovered more rapidly following irradiation in the IR+LF group compared with the IR group. Treatment of the irradiated mice with LF significantly reduced the DNA damage. In the hepatic tissue the level of superoxide dismutase in the IR+LF group was significantly increased, while malondialdehyde was significantly decreased compared with the IR group. These findings indicate that LF may prevent radiation damage and may have potential as a treatment for patients with cancer who receive radiotherapy.

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Section: Introductionmentioning

confidence: 97%

Radioprotective effect of lactoferrin in mice exposed to sublethal X‑ray irradiation

Qin

et al. 2018

Exp Ther Med

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“…In 2007, the existence of LF in murine follicular fluid and the correction between its concentration and embryonic development rates has been reported [75]. In 2008, the effect of bovine LF on the CTXtreated mouse ovaries was evaluated, and the results showed that the bovine LF administration rescued the CTX-induced ovarian damages with the gene expression level of Adamts1 and Sohlh1 and the protein expression of PCNA remarkably up-regulated [24]. In 2008, Stevenson et al reported that after oral supplements of bovine LF for 7 d, the total, helper and cytotoxic T-cell activation and hydrophilic antioxidant status of male volunteers were significantly promoted [44].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of recombinant human lactoferrin on the premature ovarian failure in rats after cyclophosphamide treatments

Liu

et al. 2021

J Ovarian Res

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This study investigated the effect of recombinant human lactoferrin (rhLF) on the premature ovarian failure (POF) of rats. After cyclophosphamide treatments, the POF rats were divided into the following groups: normal control group (NC), low-dose group (LD), medium-dose group (MD) and high-dose group (HD) of rhLF. After drug administrations, the ovarian indexes and hormonal levels were detected. After follicle number count, the proliferation and apoptosis were analyzed with the expressions of genes related with oogenesis, reactive oxygen species (ROS) production and apoptosis detected, followed by the calculation of oxidative stress and protein expressions. After 4-hydroperoxy cyclophosphamide (4-HC) treatments, the effect of rhLF on the proliferation, ROS production and gene expressions of primary rat granulosa cells (GCs) cultured in vitro were detected. After mating, the fertilities of POF rats were recorded. The result showed that the rhLF administrations up-regulated the ovarian index with the number of developing follicles increased and the decreases of hormonal levels conferred. The Ki-67 intensities of the MD and HD groups were up-regulated with the Tunnel intensities decreased. The rhLF treatments significantly promoted the expression of oogenesis, antioxidant and anti-apoptosis related genes. The expression of Bax and Caspase 3 were decreased with the expression of Bcl-2 up-regulated after rhLF administrations. The in vitro treatments of rhLF effectively conferred the toxicity of 4-HC on primary rat GCs. The fertility assessment showed the rhLF treatments up-regulated the offspring’s’ folliculogenesis, which confirmed the ameliorative role of rhLF on the POF damages via the inhibition of ROS production in GCs.

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“…These results also indicated that ingested bLF exerts various biological responses without directly interacting with target organs, since barely detectable amounts of bLF and its large fragments are absorbed by the intestines [9]. In animal models, the oral administration of bLF has been reported to attenuate colitis [10], inhibit hepatic inflammation derived from oxidative liver damage [11], and protect against oocyte depletion induced by cyclophosphamide [12]. Previously, we demonstrated that orally T. Kuhara (&) Á K. Yamauchi Á K. Iwatsuki Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 228-8583, Japan e-mail: t_kuhara@morinagamilk.co.jp ingested bLF stimulated interleukin-18 (IL-18) production in the intestinal epithelium and type I interferon production in Peyer's patches, thereby enhancing peripheral NK cell activity in mice [13].…”

Section: Introductionmentioning

confidence: 89%

Bovine lactoferrin induces interleukin-11 production in a hepatitis mouse model and human intestinal myofibroblasts

Kuhara¹,

Yamauchi²,

Iwatsuki³

2011

Eur J Nutr

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Lactoferrin is associated with a decrease in oocyte depletion in mice receiving cyclophosphamide

Abstract: The present report suggests that lactoferrin helps to rescue the ability to ovulate and partially to prevent oocyte depletion in mouse ovaries.

Cited by 10 publications

References 38 publications

Radioprotective effect of lactoferrin in mice exposed to sublethal X‑ray irradiation

Radioprotective effect of lactoferrin in mice exposed to sublethal X‑ray irradiation

Ameliorative effect of recombinant human lactoferrin on the premature ovarian failure in rats after cyclophosphamide treatments

Bovine lactoferrin induces interleukin-11 production in a hepatitis mouse model and human intestinal myofibroblasts

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