Lactoferrin expression in the canine uterus during the estrous cycle and with pyometra

Kida, Kenichi; Baba, Eiichiroh; Torii, Ryuzo; Kawate, Noritoshi; Hatoya, Shingo; Wijewardana, Viskam; Sugiura, Kikuya; Sawada, Tsutomu; Tamada, Hiromichi; Inaba, Toshio

doi:10.1016/j.theriogenology.2006.04.028

Cited by 26 publications

(21 citation statements)

References 36 publications

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“…could also been detected [11,22,23] . It has been established that if E. coli migrates to the uterus, it binds with higher affinity to the endometrium and myometrium layers and constitutes a resistance to the uterus' defense mechanisms such as lactoferrin and mucin-1 [24][25][26][27] . As reported in previous studies [4,11,23,28] , gram negative bacteria (75%) such as E. coli, Klebsiella spp.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, bacterial endotoxins induce a marked increase in the number of circulating polymorphonuclear phagocytes (regenerative left shift). In addition, anemia could be observed due to the bone marrow suppression by bacterial endotoxins [2,24,[30][31][32] . In the present study, the changes in the different degrees were observed in the blood biochemical and hematological parameters in bitches with isolated gram negative bacteria.…”

Section: Discussionmentioning

confidence: 99%

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Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Demırel¹,

Vural²,

Vural³

et al. 2018

Kafkas Univ Vet Fak Derg

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The object of this study was to compare the histopathologic change in uterus as well as the findings of clinical and bacteriological of twentyfour bitches with pyometra. Uterine lesions were grouped as acute endometritis, subacute endometritis, acute metritis, subacute metritis. Complete blood-count, blood biochemical parameters and toxin levels were determined. Only alkaline phosphatase levels were significantly different between all groups (P<0.01). Blood endotoxin level was different between the acute and subacute endometritis groups (P<0.01), and subacute endometritis and acute metritis groups (P<0.01). All bitches in the subacute endometritis group recovered. Three bitches in the acute endometritis group, two bitches in the acute metritis group and one bitch in the subacute metritis group died. The blood endotoxin level was determined to be quite high in the dead bitches. There was a difference in the levels of blood urea nitrogen (P<0.05), creatinine (P<0.01), and toxin (P<0.0001) between the dead and surviving bitches. In conclusion, the prognosis of pyometra may be recovered in bitches diagnosed with subacute endometritis associated with low levels of circulating endotoxin. The endotoxemic bitches that have blood endotoxin level above 0.96 EU/mL along with significantly increased alkaline phosphatase, blood urea nitrogen, and creatinine concentration would likely end up with a mortality outcome for acute endometritis, acute metritis, or subacute metritis. These parameters may serve as good prognostic markers in bitches with pyometra. Keywords: Bacteriology, Bitch, Histopathology, Prognosis, Pyometra Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri ÖzBu çalışmanın amacı, pyometralı yirmi dört köpeğin uteruslarındaki histopatolojik değişikliklerin karşılaştırılmasıdır. Uterus lezyonları akut endometritis, subakut endometritis, akut metritis, subakut metritis olarak gruplandırıldı. Tam kan sayımı, kan biyokimyasal parametreler ve toksin seviyeleri belirlendi. Tüm gruplar arasındaki farklılık sadece alkalen fosfotaz seviyesinde önemliydi (P<0.01). Kan endotoksin seviyesi, akut ve subakut endometritis grupları (P<0.01) ile subakut endometritis ve akut metritis grupları (P<0.01) arasında farklıydı. Subakut endometritis grubundaki tüm köpekler iyileşti. Akut endometritis grubunda üç köpek, akut metritis grubunda iki köpek ve subakut metritis grubunda ise bir köpek öldü. Kan endotoksin seviyesinin ölen köpeklerde oldukça yüksek seviyede olduğu belirlendi. Ölen ve yaşayan köpekler arasında kan üre nitrojen (P<0.05), kreatinin (P<0.01) ve toksin (P<0.0001) seviyelerinin farklı olduğu görüldü. Sonuç olarak, dolaşımdaki endotoksinin düşük seviyesi ile ilişkili olarak subakut endometritis tanısı konulan köpeklerde pyometranın prognozunun iyileştirilebileceği düşünüldü. Yüksek seviyede alkalen fosfotaz, kan üre azotu ve kreatinin konsantrasyonu ile birlikte 0.96 EU/mL'nin üstündeki kan endotoksin düzeyine sahip endotoksemik köpeklerde akut endometritis, akut metritis veya ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Demırel¹,

Vural²,

Vural³

et al. 2018

Kafkas Univ Vet Fak Derg

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“…The cystic endometrial hyperplasia-pyometra complex (CEH/P), earlier called the endometritis-pyometra complex (EPC), is one of the most serious and most common uterine diseases in bitches (Kida et al 2006). It is defined as the acute or chronic, polysystemic, di-oestrual disorder of the adult bitch, characterised by hyperplasia of the endometrium and infiltration of inflammatory cells and it may occur in all layers of the uterus.…”

Section: The Pathogenesis Of Endometritispyometra: Clinical Featuresmentioning

confidence: 99%

“…The etiopathogenesis has not been fully explained so far, but it is known that hormonal disorders and bacterial infections are the underlying causes of this complex and that the main pathological processes occur in the uterus. The ovarian abnormality and hormonal disorders resulting from the prolonged influence of estrogens (prolonged heat, ovarian cysts, active ovarian neoplasia) are thought to be the main cause of endometritis-pyometra complex (Kida et al 2006). Changes in the concentration of ovarian steroid hormones in the blood and in their receptors in uteri with pyometra were investigated (de Bosschere and Ducatelle 2002).…”

Section: The Pathogenesis Of Endometritispyometra: Clinical Featuresmentioning

confidence: 99%

Endometritis and pyometra in bitches: a review

Kempisty¹,

Bukowska²,

Woźna³

et al. 2013

Vet. Med.

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Endometritis-pyometra is the most frequent and complex pathology in domestic bitches. This process involves several immunological changes as well as molecular mechanisms responsible for inflammation in the female uterus. The various clinical stages of pyometra are associated with various symptoms. In this review, several aspects are described, including physiological and pathological mechanisms as well as molecular changes which take place during induction of endometritis-pyometra. The authors also highlight the important role of growth factors and their receptors in this process. It is well known that pyometra is a compound process which mainly involves immunological changes during inflammation. However, this review presents a new overview of this process, which includes changes at the molecular level, e.g., the altered expression of genes crucial for the development of this disease. Although pyometra is the most frequent disease of the reproductive tract in bitches, the molecular basis of this process is still not entirely understood.

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“…A lactoferrina, uma glicoproteína ligada ao ferro, pertencente à família das transferrinas, apresenta atividade bactericida potencial contra a Escherichia coli, por meio da limitação da disponibilidade de ferro nos tecidos (NUIJENS; VAN BERKEL, 1996;SALLMANN et al, 1999). De acordo com Kida et al (2006), a expressão de lactoferrina no útero durante a HEC-Piometra está relacionada às concentrações séricas de estrógeno e a diminuição significativa desta glicoproteína no período inicial do diestro pode prejudicar o mecanismo de defesa do organismo. Os referidos pesquisadores demonstraram aumento marcante na expressão gênica da lactoferrina, principalmente nos neutrófilos presentes no útero de cadelas com a afecção, e concluíram que este mecanismo minimiza ou anula a ação bacteriana nos tecidos.…”

Section: Agentes Infecciosos Na Hec-piometraunclassified

Caracterização das alterações hemodinâmicas do útero em cadelas com hiperplasia endometrial cística-piometra

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Lactoferrin expression in the canine uterus during the estrous cycle and with pyometra

Cited by 26 publications

References 36 publications

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Endometritis and pyometra in bitches: a review

Caracterização das alterações hemodinâmicas do útero em cadelas com hiperplasia endometrial cística-piometra

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