Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Demırel, Mürşide Ayşe; Vural, Sevil Atalay; Vural, Mehmet Rıfat; Kutsal, Osman; Günen, Ziynet; Küplülü, Şükrü

doi:10.9775/kvfd.2018.19675

Cited by 3 publications

(1 citation statement)

References 27 publications

(47 reference statements)

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“…All these observations that found in feline pyometra as reported previously in Agudelo [28] and Wen-yanget al [29]. In addition, the bitches with pyometra, similar findings were found in Qian and Hou [30] and Demirelet al [31].…”

Section: Discussionsupporting

confidence: 85%

The Efficacy of Medical Treatment of Pyometra in Queens with Special Reference to Histopathological Changes

Abdallah

Elgebaly²,

Raouf³

et al. 2023

Zagazig Veterinary Journal

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Pyometra is regarded as a serious issue that poses a threat to the life of queens. The risk of pyometra brought on by toxicity and the incidence of septicemia. The most effective and conventional treatment for pyometra is surgical removal of the pus source (the female reproductive tract) which known as spaying operation (ovariohysterectomy).However, medical treatment may be applied if maintaining reproductive ability is desired. In the presentstudy, 30queens were employed and split into 2groups. In G1 (n:15), queens received 1µg /kg/24 h of PGF2αintramuscularlyand (half tab/day/orally) of Amoxicillin-Clavulanate 1g(chosen based on the result of sensitivity test) for 7 days. Cats in group 2 (n=15) received the same therapy as group 1 with the addition of oral dopamine agonist (5 µg /kg/24 h). The general health condition of the queen and the presence of genital discharge was followed up during the treatment period. the recurrence of this problem was recoded every 4 months. Additionally, the diameter of uterine horns was assessed daily using ultrasoundfrom the beginning of the treatment.After receiving treatment for one week, queens inG1 and G2 no longer had any clinical signsof pyometra or genital purulent discharge. Six cats (40%) in G1 showedtheir first recurrent pyometra on within 4monthsafter the start of treatment. But four cats (26.6%) in G2showedthe first recurrence between the 4 th and 8 th month after the first treatment.The returned cats from the second treatment trial, were exposed to ovariohysterectomy and then apply the histopathological examination.In conclusion,using cabergoline with PGF2αachiever more rapid involution of the uterus and lower recurrence rate than using PGF2α alone.

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Section: Discussionsupporting

confidence: 85%

The Efficacy of Medical Treatment of Pyometra in Queens with Special Reference to Histopathological Changes

Abdallah

Elgebaly²,

Raouf³

et al. 2023

Zagazig Veterinary Journal

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Pathological and molecular diagnosis of concurrent canine babesiosis and pyometra in a Belgian Malandis bitch

et al. 2021

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First report on clinical aspects, blood profiles, bacterial isolation, antimicrobial susceptibility, and histopathology in canine pyometra in Thailand

Lansubsakul

Sirinarumitr

et al. 2022

Vet World

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Background and Aim: Canine pyometra, either the closed (closed pyometra [CP]) or open (open pyometra [OP]) cervix type, is a frequent uterine disease in intact old age bitches. Therefore, early diagnosis and appropriate medical and surgical treatments are crucial to avoid the life-threatening condition in these bitches. This study aimed to investigate clinical alterations, blood parameters, causative bacteria, antimicrobial susceptibility, and uterine histopathology obtained during aseptic surgical treatment on bitches with pyometra. Materials and Methods: Sixty bitches of various breeds and ages with presumptive pyometra diagnoses were included in the study. The diagnoses were based on history, clinical examination, blood parameters, radiography, and ultrasonography. All pyometra bitches were ovariohysterectomized as an emergency surgical treatment. In addition, uterine content and tissues were submitted for bacterial isolation, antimicrobial susceptibility, and uterine histopathological analysis. Results: Except for abdominal CP distention, no specific clinical signs were linked to the pyometra type. The mean values of total white blood cell count (WBC) and plasma protein were predominantly raised in pyometra bitches regarding hematological parameters. Leukocytosis was found in both types; however, the WBC in CP was markedly higher than in OP. The mean value of blood urea nitrogen increased in the CP group. Klebsiella pneumoniae and Escherichia coli were the most frequent causative bacteria isolated in CP and OP, respectively. All isolated bacteria were 100% susceptible to imipenem, meropenem, and carbapenem. Marbofloxacin was the second most effective drug against isolated bacteria from both groups. Uncomplicated cystic endometrial hyperplasia (CEH) was not presented in the CP group. CEH and chronic endometritis (type IV), the most severe uterine histopathological changes, were discovered in the CP and OP. Conclusion: The CP and OP groups presented leukocytosis, increased plasma protein, and CEH and chronic endometritis. Depression, abdominal distention, and enlarged uterine size were the major characteristics of the CP group. Furthermore, abdominal distension is presented in other abnormalities in clinical practices, providing a differential diagnosis. Drugs in the carbapenem group were the most effective against isolated bacteria; however, they are not routinely used due to bacterial resistance concerns. Thus, marbofloxacin was recommended as an alternative medical treatment because it is convenient to manage by both oral and injection routes.

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Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Cited by 3 publications

References 27 publications

The Efficacy of Medical Treatment of Pyometra in Queens with Special Reference to Histopathological Changes

The Efficacy of Medical Treatment of Pyometra in Queens with Special Reference to Histopathological Changes

Pathological and molecular diagnosis of concurrent canine babesiosis and pyometra in a Belgian Malandis bitch

First report on clinical aspects, blood profiles, bacterial isolation, antimicrobial susceptibility, and histopathology in canine pyometra in Thailand

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