Lactoferrin alleviates cyclophosphamide induced-nephropathy through suppressing the orchestration between Wnt4/β-catenin and ERK1/2/NF-κB signaling and modulating klotho and Nrf2/HO-1 pathway

Mohamed, Ola S.; Baky, Nayira A. Abdel; Sayed‐Ahmed, Mohamed M.; Al-Najjar, Aya H.

doi:10.1016/j.lfs.2023.121528

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Cited by 7 publications

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“…55 We have previously reported a close correlation between the induction of ROS-derived liver lipoperoxidation and the appearance of preneoplastic lesions. 38 On the other hand, the antioxidant potential of bLf has been widely documented; 52,56,57 however, it has been mostly attributed to the iron sequestering capability of native- or apo-bLf, since iron is a well-known pro-oxidant that induces ROS production through the Fenton reaction. 58 Therefore, we verified that iron-saturated bLf did not increase ROS production beyond the increase produced by DEN.…”

Section: Discussionmentioning

confidence: 99%