Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function

Braat, Henri; Brande, Jan Van den; Tol, Erik van; Hommes, Daan W.; Peppelenbosch, Maikel P.; Deventer, Sander van

doi:10.1093/ajcn/80.6.1618

Cited by 193 publications

(136 citation statements)

References 34 publications

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“…We, however, did not find any significant changes in bacteria-induced production of cytokines apart from the TNF-α in the PBMC cultures of our study subjects after L. rhamnosus GG treatment. In another study with healthy adults and with patients with Crohn's disease, L. rhamnosus GG decreased the production of IL-2, IL-10 and IL-4 from PBMCs sorted as naïve and memory T cells [33] . It seems that L. rhamnosus GG has a role in modulating the cytokine responses and may possess an anti-inflammatory potential in healthy individuals.…”

Section: Discussionmentioning

confidence: 90%

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

Kekkonen

Lummela²,

Karjalainen³

et al. 2008

WJG

184

152

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freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS:The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo.IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION:In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults.

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Section: Discussionmentioning

confidence: 90%

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

Kekkonen

Lummela²,

Karjalainen³

et al. 2008

WJG

184

152

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“…rhamnosus) was shown to modulate DC function to induce a novel form of T-cell hyporesponsiveness [97]. Another study in mice demonstrated that the probiotic preparation VSL #3 increased the expression of B7.1 (CD80), B7.2, CD40 and MHC class II molecules.…”

Section: Activation Of Tolerogenic Dendritic Cells (Dcs)mentioning

confidence: 99%

Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity

Dwivedi

Kumar

Laddha³

et al. 2016

Autoimmunity Reviews

119

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“…Lactobacillus rhamnosus GG decreased T cell proliferation and cytokine production, especially of IL-2, IL-4 and IL-10, such as demonstrated in CD3 ⁄ CD28-stimulated T cells derived from dendritic cells matured in the presence of Lact. rhamnosus GG (Braat et al 2004). However, bacterial cell components involved in the modulatory properties of Lact.…”

Section: Introductionmentioning

confidence: 99%

Intermediate chains of exopolysaccharides fromLactobacillus rhamnosusRW-9595M increase IL-10 production by macrophages

Bleau

Monges

Rashidan

et al. 2010

Journal of Applied Microbiology

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Aims: To evaluate the immunosuppressive properties of the exopolysaccharide (EPS) from high‐EPS producer Lactobacillus rhamnosus RW‐9595M on inflammatory cytokines produced by macrophages. Methods and Results: The conditioned media (CM) were produced by macrophages treated with parental Lact. rhamnosus ATCC 9595 and its isogenic variant, the high‐EPS producer Lact. rhamnosus RW‐9595M, and the levels of TNF‐α, IL‐6, IL‐10 and IL‐12 were evaluated. Results revealed that CM from parental Lact. rhamnosus induced higher levels of TNF‐α, IL‐6 and IL‐12 but inhibited IL‐10 production, whereas its mucous variant induced low or no TNF‐α and IL‐6. Addition of purified EPS to macrophages treated with parental Lact. rhamnosus decreased the inflammatory cytokines and inhibited the metabolic activity of lymphocytes. The intermediate polysaccharide chains (16–30 units) produced by time‐controlled hydrolysis of EPS increased the IL‐10 produced by macrophages. Conclusions: Polysaccharide chains of EPS induced immunosuppression by the production of macrophagic anti‐inflammatory IL‐10. Significance and impact of the Study: These results indicate that the EPS from Lact. rhamnosus RW‐9595M may be useful as a new immunosuppressive product in dairy food.

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Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function

Abstract: We propose that L. rhamnosus modulates DC function to induce a novel form of T cell hyporesponsiveness; this mechanism might be an explanation for the observed beneficial effects of probiotic treatment in clinical disease.

Cited by 193 publications

References 34 publications

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity

Intermediate chains of exopolysaccharides fromLactobacillus rhamnosusRW-9595M increase IL-10 production by macrophages

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