Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity

Dwivedi, Mitesh; Kumar, Prasant; Laddha, Naresh C.; Kemp, E. Helen

doi:10.1016/j.autrev.2016.01.002

Cited by 114 publications

(90 citation statements)

References 192 publications

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“…The present study has shown that Th17 is abnormally expressed in IBD patients. Regulatory T cells (Treg) is another kind of CD4 + T lymphocyte subset, mainly mediating the inhibition of autoimmunity 10-12. Th17 and Treg can be mutually transformed.…”

Section: Introductionmentioning

confidence: 99%

Expression of Treg/Th17 cells as well as related cytokines in patients with inflammatory bowel disease

Geng

Xue

2016

Pak J Med Sci

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Objective:To investigate the expressions of peripheral regulatory T cells (Treg) and T helper cells (Th17) as well as related cytokines in peripheral blood of patients with inflammatory bowel disease (IBD).Methods:One hundred four cases of IBD patients admitted in our hospital were selected for this study. One hundred cases of people receiving healthy physical examination were included in the control group in the corresponding period. The levels of CD4+CD25+Treg and Th17 subsets were analyzed in peripheral blood of two groups using flow cytometry. The expressions of IL-10, TGF-β1, IL-17 and IL-23 mRNA and protein were detected using real-time fluorescence quantitative PCR and ELISA.Results:Compared with the control group, the proportion of Treg in peripheral blood was decreased significantly in observation group (P<0.05), the proportion of Th17 cells was increased significantly (P<0.05), and Treg/Th17 was decreased significantly (P<0.05). Compared with the control group, the expressions of IL-10 and TGF-β1 mRNA and protein in peripheral blood of patients were significantly down-regulated in observation group, while the expressions of Th17 cytokines IL-17 and IL-23 mRNA and protein were significantly increased (P<0.05).Conclusion:The proportion of Th17 and increased cytokine level suggested the inflammatory level was higher in IBD patients. The down regulations of Treg and cytokine suggested that the immunosuppression function was down-regulated in IBD patients, and the disproportionality might be one of the mechanisms of IBD.

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Section: Introductionmentioning

confidence: 99%

Expression of Treg/Th17 cells as well as related cytokines in patients with inflammatory bowel disease

Geng

Xue

2016

Pak J Med Sci

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“…Lactobacillus acidophilus, Bifidobacterium bifidum, and Bifidobacteria infantum administration in a rat model of colon cancer was also reported to exert anti-cancer effects through TLR2 signaling (14). Therefore, Treg activation by probiotics has been delineated as one of the triggered mechanisms to suppress abnormal inflammation and subsequent complications, including colorectal cancer (77,78).…”

Section: Microbiota Contribution In Favor Ofmentioning

confidence: 99%

“…In addition, SCFAs, PSA production by specific probiotic species, and microbial metabolites (generated through food digestion) have been introduced to be involved in Treg induction by probiotics (77). Lactobacillus acidophilus, Bifidobacterium bifidum, and Bifidobacteria infantum administration in a rat model of colon cancer was also reported to exert anti-cancer effects through TLR2 signaling (14).…”

Section: Microbiota Contribution In Favor Ofmentioning

confidence: 99%

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Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer

2016

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Colon microbiota, as a complex and diverse population, has been shown to be either pro-or anti-tumorigenic, depending on its content. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which proor anti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance in microbiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.

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“…1B). (Tsai et al, 2012;Ma et al, 2015;Dwivedi et al, 2016) 및 전신성 염증 반응의 발달에 중요한 역할을 한다 (Wei et al, 1995). TNF-α는 수지상세포를 성숙시켜 T 세포의 활성과 성장 등을 조절하며, 암세포의 살상 및 암 전이의 억제 작용 등의 항암작용을 나타낸다 (Strieter et al, 1993;Kikuchi et al, 2003).…”

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Immunomodulatory Effects of Fermented Milk based on Synbiotic Interaction between Cudrania tricuspidata Leaf Extract and Lactobacillus gasseri 505

Lee¹,

Kim²,

Shin³

et al. 2018

J. Milk Sci. Biotechnol.

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Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity

Abstract: Regulatory T cells (Tregs

Cited by 114 publications

References 192 publications

Expression of Treg/Th17 cells as well as related cytokines in patients with inflammatory bowel disease

Expression of Treg/Th17 cells as well as related cytokines in patients with inflammatory bowel disease

Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer

Immunomodulatory Effects of Fermented Milk based on Synbiotic Interaction between Cudrania tricuspidata Leaf Extract and Lactobacillus gasseri 505

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