Lactate Dehydrogenase Virus and Mouse Embryos

Crispens, Charles G.

doi:10.1038/214819a0

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…However, it’s worth noting that BCAA levels are positively associated with obesity and to the development of type II diabetes mellitus (T2DM) [ 65 , 66 ]. Further evidence suggests that excess BCAA may be a marker of insulin resistance or even be causative [ 67 , 68 ]. Considering that insulin resistance is an underlying pathology of several neurodegenerative diseases, it is plausible that excess BCAAs persistently overstimulate mTORC1, resulting in the p70S6K1-mediated negative feedback on IRS-1.…”

Section: Mechanistic Target Of Rapamycin: Pathways and Regulationmentioning

confidence: 99%

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Querfurth

Lee

2021

Mol Neurodegeneration

140

117

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Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamycin (mTOR). As a nutrient sensor, mTOR has important homeostatic functions to regulate energy metabolism and support neuronal growth and plasticity. However, in Alzheimer’s disease (AD), mTOR alternately plays important pathogenic roles by inhibiting both insulin signaling and autophagic removal of β-amyloid (Aβ) and phospho-tau (ptau) aggregates. It also plays a role in the cerebrovascular dysfunction of AD. mTOR is a serine/threonine kinase residing at the core in either of two multiprotein complexes termed mTORC1 and mTORC2. Recent data suggest that their balanced actions also have implications for Parkinson's disease (PD) and Huntington's disease (HD), Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). Beyond rapamycin; an mTOR inhibitor, there are rapalogs having greater tolerability and micro delivery modes, that hold promise in arresting these age dependent conditions.

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Section: Mechanistic Target Of Rapamycin: Pathways and Regulationmentioning

confidence: 99%

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Querfurth

Lee

2021

Mol Neurodegeneration

140

117

View full text Add to dashboard Cite

show abstract

“…It seems likely that this is the method of cross-infection by which the virus is maintained in feral mice, a number of which have been found to be infected in Europe, America and Australia. Transplacental infection often occurs if the mother is infected during pregnancy but is much less likely in chronically infected females (Notkins & Scheele, 1963;Georgii et al, 1964;Crispens, 1967;Moty~ka et al, 1976 b). The infected male seldom transmits the virus but it is reported that, when an infected male is mated to an uninfected female, there are more females in the litter than expected, although none is infected (Crispens, 1969).…”

Section: Introductionmentioning

confidence: 99%