Lactate Dehydrogenase-elevating Virus

Production, characterization and reactivity of monoclonal antibodies to porcine reproductive and respiratory syndrome virus

“…With EAV, variation has been detected within an outbreak, between virus isolates from the same carrier stallion over an extended period and also among isolates worldwide (Murphy et al, 1992). The genomic variability of LDV has also been described in reviews by Rowson & Mahy (1985), and Plagemann & Moennig (1992). High mutation rates are a feature of RNA viruses (Holland et al, 1982), and can lead to the establishment of heterologous populations, described as quasispecies (Domingo et al, 1985).…”

Replication of lactate dehydrogenase-elevating virus in cells infected with murine leukaemia viruses in vitro

“…Cells or cell lines other than macrophages which are permissive for LDV in vitro have not yet been detected despite extensive study (Stueckemann et al, 1982;Rowson & Mahy, 1985): The cells employed in this study also failed to support LDV infection and replication unless these cells had been infected with ecotropic MuLV. Infection by LDV was observed in various ecotropic MuLV-infected cells, but the extent of infection varied cons!derably from virus strain to strain and from cell line to cell line.…”

Lactate Dehydrogenase-elevating Virus Induces Anti-Golgi Apparatus Antibodies

“…Infection with LDV has a broad immunoregulatory potential. As reviewed recently by Rowson & Mahy (1985) antigen-presenting macrophages are affected as well as B and T lymphocytes. Notkins et al (1966) had observed greatly increased levels of immunoglobulins in the plasma of LDV-infected mice.…”

“…The detection of the capacity of LDV to induce antibodies against tumour surface antigen may eventually contribute to elucidation of the effects on the growth of various tumours (for review, see Rowson & Mahy, 1985).…”