Lactate dehydrogenase, isoenzyme patterns and cation levels in human breast gross cyst fluid

Biagioni, Stefano; Mannello, Ferdinando; Stella, Francesco; Battistelli, Serafina; Marcheggiani, F.; Cerroni, Lorenzo; Artico, Marco; Terzano, Claudio; Troccoli, R

doi:10.1016/0009-8981(87)90397-4

Cited by 12 publications

(2 citation statements)

References 10 publications

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“…Some enzymes show activities that vary widely in BCF over a 300-fold range [23, 94,112,142,152,155,156], are pathophysiologically important influencing the ratio of unconjugated:glucuronidated estradiol [151], or hydrolysing fatty acid esters of steroids [147][148][149]. Increased Immunoglobulin M [103,127,128] Interleukin-1 (a e b) [129,130] Interleukin-2 [110,131] Interleukin-4 [132] Interleukin-6 [129,131] Interleukin-8 [131] Intercellular adhesion molecule-1 (ICAM-1) [129] a-Lactalbumin [123,133] Lactoferrin [21, 106,107] Lysozyme [103,107] Oncostatin M [131] Platelet factor-4 [134] Plasminogen [135] pS 2 [136] Steroid-binding globulin [82,105] b-Thromboglobulin [134] Thrombospondin [134,137] Tissue-type plasminogen activator [135] Transcortin-like protein [138] Transferrin [103,112,122] Urokinase-like plasminogen activator [135] Vascular cell adhesion molecule-1 (VCAM-1) [121] Zn-a 2 -glycoprotein (GCDFP-44) [103,10...…”

Section: Enzymes and Proteinasesmentioning

confidence: 99%

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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For more than one and a half century the cystic disease of the breast has been recognized as the most frequent female benign breast lesion. Although some conundrums and controversies exist about the relation between gross cysts and breast cancer, recent evidence suggests that the multidisciplinary study of gross cystic breast disease (GCBD) may be a powerful tool for predicting the natural history of the multifaceted gross cyst pathology. A lot of papers have been published on breast cyst fluids (BCF) concerning biochemical, hormonal and morphological aspects, demonstrating that the intracystic fluid contains a wide variety of components (such as ions, lipids, proteins, enzymes, growth factors and antigens) and suggesting that their profile provides additional knowledge on both physiopathology and etiologic pathways of human gross cystic breast disease. The aim of this overview is the critical evaluation of all data accumulated in the last thirty years, in order to highlight the utility of biochemical and epidemiological studies to identify gross cysts, if any, at higher breast cancer risk.

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Section: Enzymes and Proteinasesmentioning

confidence: 99%

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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“…Menopoz öncesi bazı kadınlarda görülen memenin kistik hastalıklarında, kist sıvı sının biokimyasal analizi yapılarak meme kanserine yakalanma riski ara~tırılmı~tır (3,7). Bazı araştırmacılar meme kist sıvısının katyon içeriğinin, kist tipinin belirlenmesine yardımcı olacağını öne sürmüşlerdir (1,6). Eğer kist sıvısı Na+/K+ oranı 2 veya daha az ise kist apokrin epitelden, 3 den daha fazla ise düz epitelden kaynaklanmaktadır (3,5).…”

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Transferrin, Ferritin And Na/K Levels in Serum And Breast Cyst Fluid

Erkizan¹,

Gürsu²

1992

Tepecik Dergisi

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SUMMARYFerritin and transferdn, as potential markers for cells undergo:ing division, as well as Na and K concerıtrations were investigated in serum and breast cyst fluid of 25 patients to determine breast cancer risk, Mo.reover, Na+ and K+ levels were measured in breast fh.ıids. The relationship between the levels of these two ironb:inding protei:ns and the Na and K concentrations suggest to an increased local biosynHı.etk ad:ivity pointing out to a higher cancer risk.In this study, mean serum concentration or transferrin and ferritin has been found as 438,8+60,9 ıngldl and 73,2+41.7 ng/ml respectively. In breast transferrin and :fe.rritin mean values were 211A+125.2 ıngldl and 373.2+170.2 ng/ml. Na/K :ratio in breast cyst fluid, asa ırisk indi. Bir risk göstergesi olan Na/K oranının 2'nin altına 25 olgunun 19'unda izlendi.

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Breast cancer diagnosis by lactate dehydrogenase isozymes in nipple discharge

Kawamoto¹

1995

Cancer

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Lactate dehydrogenase, isoenzyme patterns and cation levels in human breast gross cyst fluid

Cited by 12 publications

References 10 publications

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Transferrin, Ferritin And Na/K Levels in Serum And Breast Cyst Fluid

Breast cancer diagnosis by lactate dehydrogenase isozymes in nipple discharge

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