Lactate dehydrogenase as a biomarker in oral cancer and oral submucous fibrosis

Abstract

Salivary LDH levels were consistently higher in OSMF and oral cancer; hence, it could be a future biomarker.

Lactate Dehydrogenase as a Tumor Marker in Oral Cancer and Oral Potentially Malignant Disorders: A Biochemical Study

“…The comparison of salivary LDH levels between OSMF and healthy subjects was statistically significant (p < 0.001). Our study findings were consistent with the study conducted by Sivaramakrishnan et al, 3 Kallalli et al, 1 Bhambal et al, 2 Shetty et al, 16 Rathore et al, 9 Pereira et al, 6 and Muralidhar et al 14 According to WHO 2005, oral leukoplakia is defined as a predominantly white patch or plaque that cannot be characterized clinically or pathologically as any other disorder; oral leukoplakia carries an increased risk of cancer development either in or close to the area of leukoplakia or elsewhere in the oral cavity or the head and neck region. 17 Malignant transformation rate of oral leukoplakia varies from 0.13 to 34%.…”

“…The comparison of salivary LDH levels between oral cancer and healthy subjects was statistically significant (p < 0.001). Our study finding was in agreement with the study done by Kallalli et al, 1 Lokesh et al, 8 Shetty et al, 16 Patel and Metgud, 4 and Joshi et al…”

“…5 Lactate dehydrogenase is a cytoplasmatic enzyme present essentially in all major organ systems. 1 The extracellular appearance of LDH is used to detect cell damage or cell death. Due to its extraordinarily widespread distribution in the body, serum LDH is abnormal in a host of disorders.…”

“…1 Oral cancer is often preceded by potentially malignant disorders (PMDs), with more emphasis being placed on early detection, since diagnosis at an early stage is comparatively easier and is the key to reduce mortality and morbidity. 2,3 Recently, the role of tumor markers in the management of head and neck cancer has increased for attention.…”

“…Lactate dehydrogenase (LDH) is one among them, which is a ubiquitous enzyme that plays a significant role in the diagnosis of pathologic processes. 1 This enzyme catalyzes the reaction of lactate production via pyruvate reduction during anaerobic glycolysis. 6 Lactate dehydrogenase is believed to vary according to the metabolic requirement of each tissue, and alteration in LDH levels has been observed during development, under changing biological conditions, and in response to pathological processes.…”