Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

Augoff, Katarzyna; Hryniewicz-Jankowska, Anita; Taboła, Renata

doi:10.1016/j.canlet.2014.12.035

Cited by 190 publications

(164 citation statements)

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“…D-dimers are a sensitive measure of endogenous fibrinolysis and are used to screen for deep vein thrombosis (19)(20)(21)(22)(23)(24). Elevated LDH levels have frequently been observed in animal and human malignancies (15,25,26); in addition, there appears to be a strong correlation between disease activity and tumor mass (27). The association, pathogenesis and significance of D-dimers and LDH levels with relapse within the subtypes of AML and ALL are currently unknown.…”

Section: Discussionmentioning

confidence: 99%

“…LDH activity reflects increased glycolysis in the cytoplasm of malignant cells accompanied by a high metabolic rate (15,25). The increase of serum LDH activity may be due to thrombotic microangiopathy, intravascular hemolysis or tumor lysis (25,26). Certain values from the ALL patients were remarkably high (Table II), and the majority of these patients had a high WBC counts during relapse.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of D-dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia

Wang

Yang

2016

Oncology Letters

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Abstract. Despite the outstanding advances made over the past decade regarding our knowledge of acute leukemia (AL), relapsed AL remains to be associated with a dismal prognosis. A better understanding of AL relapse and monitoring of the D-dimer and lactate dehydrogenase (LDH) plasma levels following chemotherapy may aid clinicians in determining whether relapse may occur in the subsequent phases of the disease. The present study evaluated D-dimer and LDH levels in 204 patients with relapsed AL. Data were collected at the initial onset of AL, at complete remission (CR) and in patients with relapsed AL. D-dimer plasma levels were significantly increased in patients with initial AL and in patients with relapsed AL (P=0.005 and P=0.007, respectively) but not in those with CR. LDH levels were significantly increased in AL patients at the initial onset of disease and at relapse compared with patients achieving CR, irrespective of cell type. Plasma prothrombin time, activated partial thromboplastin time and fibrinogen levels were not significantly different across patients (with the exception of acute promyelocytic leukemia patients) at the initial onset, relapsed AL or CR. Routine hematological parameters (white blood cell count, hemoglobin, platelet count) were significantly different at the initial onset of AL (P=0.002, P<0.001 and P=0.001, respectively) and during relapsed AL (P=0.009, P=0.003 and P<0.001, respectively) compared with patients achieving CR, suggesting an association between D-dimer, LDH and relapsed AL. These results also indicate that determination of D-dimer and LDH levels may be useful for predicting the probability of relapse during chemotherapy, but should also be combined with routine hematological parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of D-dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia

Wang

Yang

2016

Oncology Letters

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“…The absence of LDH-B expression and its enzyme activities have been reported in cell lines of breast , prostate (Leiblich et al, 2006), gastric and pancreatic cancer (Maekawa et al, 2003), suggested to be driven by promoter hypermethylation. As LDH-B kinetically favours the backward reaction of pyruvatelactate conversion (Augoff et al, 2014), this may suggest that LDH-A, which mostly catalyses the formation of lactate, is more relevant to cancer than LDH-B (Maekawa, 1988). However, recent evidence has shown that higher tissue expression of LDH-B correlates to overall survival in lung cancer and treatment response in breast cancer (Dennison et al, 2013;McCleland et al, 2013), highlighting the role of LDH-B in cancer progression.…”

Section: Discussionmentioning

confidence: 99%

1009 Serum lactate dehydrogenase and survival following cancer diagnosis

Wulaningsih¹,

Holmberg²,

Garmo³

et al. 2015

European Journal of Cancer

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“…Inhibition of LDHA is an area of active research in the oncology field since LDHA overexpression is associated with cancer cell growth, poor prognosis and drug resistance (2,7,39,42). Here, genetic knockdown of LDHA expression prevented radiation-induced myofibroblast differentiation (Fig.…”

Section: L885 Radiation Induces Lactate Production In Lung Fibroblastsmentioning

confidence: 94%

Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase

Judge

Owens

Pollock

et al. 2015

American Journal of Physiology-Lung Cellular and Molecular Phys

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Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

Cited by 190 publications

References 90 publications

Evaluation of D-dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia

Evaluation of D-dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia

1009 Serum lactate dehydrogenase and survival following cancer diagnosis

Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase

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