1009 Serum lactate dehydrogenase and survival following cancer diagnosis

Wulaningsih, Wahyu; Holmberg, L.; Garmo, Hans; Malmström, Håkan; Lambe, Mats; Hammar, Niklas; Walldius, Göran; Jungner, Ingmar; Ng, Talwalkar; Hemelrijck, Mieke Van

doi:10.1016/s0959-8049(16)30435-x

European Journal of Cancer

2015

DOI: 10.1016/s0959-8049(16)30435-x

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1009 Serum lactate dehydrogenase and survival following cancer diagnosis

Wahyu Wulaningsih¹,

L. Holmberg²,

Hans Garmo³

et al.

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2020

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“…For LDH, there seems to be a trend towards more elevated levels in elderly patients. This positive association between age and LDH in cancer has been noted previously, but the explanation is unclear [41]. It is well established that LDH has important prognostic value in stage IV melanoma patients and it was, therefore, incorporated in the 7th Edition AJCC staging system in 2001 [42].…”

supporting

confidence: 59%

The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients

Deckers

Kruijff

Brouwers

et al. 2020

European Journal of Surgical Oncology

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Introduction: The Standardized Uptake Value (SUV) in single lesions on 18 F-FDG PET/CT scans and serum S-100B concentrations are inversely associated with disease-free survival in stage IV melanoma. The aim of this study was to assess the association between biomarkers (S-100B, LDH) and the PET-derived metrics SUV mean/max , metabolic active tumor volume (MATV), and total lesion glycolysis (TLG) in stage IV melanoma in order to understand what these biomarkers reflect and their possible utility for followup. Methods: In 52 stage IV patients the association between PET-derived metrics and the biomarkers S-100B and LDH was assessed and the impact on survival analyzed.Results: S-100B was elevated (>0.15 mg/l) in 37 patients (71%), LDH in 11 (21%). There was a correlation between S-100B and LDH (R 2 ¼ 0.19). S-100B was correlated to both MATV (R 2 ¼ 0.375) and TLG (R 2 ¼ 0.352), but LDH was not. Higher MATV and TLG levels were found in patients with elevated S-100B (p < 0.001) and also in patients with elevated LDH (>250 U/l) (p < 0.001). There was no association between the biomarkers and SUV mean/max . Survival analysis indicated that LDH was the only predictor of melanoma-specific survival. Conclusion:In newly diagnosed stage IV melanoma patients S-100B correlates with 18 F-FDG PET/CT derived MATV and TLG in contrast to LDH, is more often elevated than LDH (71% vs. 21%) and seems to be a better predictor of disease load and disease progression. However, elevated LDH is the only predictor for survival. The biomarkers, S-100B and LDH appear to describe different aspects of the extent of metastatic disease and of tumornecrosis.

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supporting

confidence: 59%

The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients

Deckers

Kruijff

Brouwers

et al. 2020

European Journal of Surgical Oncology

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1009 Serum lactate dehydrogenase and survival following cancer diagnosis

Cited by 1 publication

References 31 publications

The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients

The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients

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