Lactate concentration in amniotic fluid at early neonatal period in perinatal hypoxia

Abstract

Aim. To determine the prognostic value of lactate concentration in amniotic fluid and umbilical cord blood of newborns at early neonatal period as indicators of increased risk of unfavorable outcome in infants with perinatal hypoxia. Methods. Determination of lactate and creatinine concentration in amniotic fluid at first stage of labor was performed by biochemical means. Determination of lactate concentration in the blood serum of infants at birth and at 3-4 days of life was also performed. Results. In timely delivery associated with perinatal hypoxia lactate concentration in amniotic fluid was increased compared to the lactate concentration in amniotic fluid during normal labor (10.6±3.18 vs 7.1±1.45 mmol/l, p 0.001). Recalculation of the lactate concentrations in amniotic fluid considering its dilution has showed a substantial difference in concentrations (0.083±0.016 vs. 0.039±0.003 mmol/l of lactate per 1 mmol/l creatinine, p 0.001). Cord blood serum lactate concentrations in newborns with perinatal hypoxia was higher compared to healthy infants (16.4±4.96 vs 9.5±3.16 mmol/l, p 0.001). Lactate concentration in umbilical cord blood serum in early neonatal period newborns rose (p 0.001), and in infants with perinatal hypoxia the increase was more significant compared to in healthy newborns (28.1±7.75 vs 13.3±3.50 mmol/l, p 0.001). Conclusion. The determination of lactate concentration in amniotic fluid at first stage of labor is an effective method to diagnose perinatal hypoxia. In early neonatal period an increase of lactate concentration in newborns, especially in newborns with perinatal hypoxia, was found.

Association of amniotic uric acid, glucose, lactate and creatinine concentrations and lactate/creatinine ratio with newborn survival in small-sized dogs – preliminary results

“…The overall median lactate concentration of the amniotic fluid (72 mg/dl) was slightly higher than that reported for humans during normal labour (7.1 ± 1.45 mmol/L, corresponding to 64 ± 13.06 mg/dl) (Korenovsky et al, 2013), but lower in comparison to data (12.5 mmol/l, corresponding to 112.6 mg/dl) reported for late-pregnant cats by Fresno et al (2012). The amniotic fluid lactate con-centrations were also studied in horses (Pirrone et al, 2012), and the mean concentrations reported for foals born from spontaneous eutocic parturition were higher (14.47 mmol/L, corresponding to 130.36 mg/dl) in comparison to data observed in the present study in dogs born by elective Caesarean section.…”