Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations

Nalbandian, Minas; Takeda, Masaki

doi:10.3390/biology5040038

Cited by 129 publications

(121 citation statements)

References 80 publications

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“…Recently, Tsukamoto et al [11] demonstrated that intraperitoneal injection of lactate in mice elicited a hypertrophic response compared to controls; importantly, lactate levels were similar to those induced by moderate repletion RT protocols, suggesting a potential physiological role. Many molecular mechanisms involved in this process are currently unknown but may be related to the relationship between [bLa -] and muscle anabolism; therefore, the mechanisms behind these adaptations have not yet been sufficiently identified, and further research is needed to support this relationship [12]. Notably, metabolite accumulation alone does not seem sufficient to substantially increase muscle mass in humans; however, it may have a positive additive effect on anabolic processes due to its capacity to generate an increase in muscle activation [13], promote the recruitment of high-threshold motor units [14], and trigger the production of myokines and reactive oxygen species that have been implicated in hypertrophic adaptations [3].…”

Section: Introductionmentioning

confidence: 99%

Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols

Vargas-Molina

Martín-Rivera

Bonilla³

et al. 2020

PLoS ONE

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The aim of this study was to compare the concentration of blood lactate [bLa-] and the subjective perception of exertion of trained men in a moderate repetition protocol (MRP) versus a high repetition protocol (HRP) equated for time under tension. Methods A sample of 40 healthy young men (aged, 23.2 ± 4.0 years; height, 177.3 ± 7.0 cm; BMI, 24.3 ± 2.2) performed two sessions of 8 sets of bicep curls with a one-week recovery interval between the trials. In the HRP protocol, 20 repetitions were performed with a cadence of 2 seconds of eccentric and 1 second of concentric, while in the MRP protocol 10 repetitions were performed with 4 seconds of eccentric and 2 seconds of concentric. Cadences were controlled by a metronome. At the beginning and end of each of the sessions, blood lactate was taken at 2, 15, and 30 minutes, and rating of perceived exertion (OMNI-RES) was assessed immediately after completion of each session. Results There were [bLa-] differences between protocols in the MRP 2 min, (5.2 ±1.4); 15 min, (3.2 ±1.2); 30 min, (1.9 ±0.6); p< 0.05, and the HRP 2 min, (6.1 ±1.6); 15 min, (3.7 ±1.1); 30 min, (2.2 ±0.6); p<0.01. OMNI-RES was higher in HRP, (8.8 ±0.7) than in MRP, (7.7 ±0.9). Additionally, a correlation was found between the RPE and [bLa-] values in the HRP protocol (rs = 0.35, p < 0.01).

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Section: Introductionmentioning

confidence: 99%

Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols

Vargas-Molina

Martín-Rivera

Bonilla³

et al. 2020

PLoS ONE

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“…Evaluating the meat quality of Nellore calves, Zorzi et al (2013) could verify that there was a close relationship between pH and other qualitative traits. After slaughter, the residual metabolic activity of the muscle causes the degradation of glycogen to lactate, which dissociates to lactic acid, causing pH to decrease (Nalbandian and Takeda 2016).…”

Section: Resultsmentioning

confidence: 99%

Qualitative traits of the meat of Nellore steers supplemented with energy and protein in an integrated crop–livestock system

Batista

Neto

Quadros³

et al. 2020

Anim. Prod. Sci.

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Context. Santa Fe is a model of integrated crop-livestock system in which grain crops and grasses are grown intercropped. After crop harvest, the pastures are grazed in the dry season and, after that, accumulate straw for no-till systems. In this way, protein and energy supplementation can contribute to finish steers on pastures, attending to the increasing demand from internal and external markets for sustainable high-quality red meat.Aim. The present study evaluated physical and chemical composition of the Longissimus dorsi meat of Nellore steers fed with increasing levels of energy and protein supplementation on Brachiaria ruziziensis pasture in Santa Fe integrated crop-livestock system.Methods. Forty chemically castrated steers were randomly assigned into four groups under a completely randomised design. Each group was supplemented one of four levels of a concentrate containing 17% crude protein and 75% of total digestible nutrients, at 0.98, 1.45, 1.86 and 2.02 kg/animal.day, representing 0.23%, 0.34%, 0.44% and 0.47% of bodyweight respectively. The experiment lasted 105 days, with trough supplementation once a day.Key results. As energy and protein increased in the diet, cooking loss decreased (P = 0.01) linearly and shearing force decreased quadratically (P = 0.02), with a strong correlation between them (r = 0.93). Subcutaneous fat thickness showed a quadratic increase (P = 0.03), with its maximum point at the concentrate supplementation level of 1.55 kg/animal.day, with a thickness of 3.36 cm and a high Pearson's correlation with the loin eye area (r = 0.94). There was a quadratic increase in C18:2n6 (P = 0.05) and a linear increase in C22:6n3 (P = 0.04) polyunsaturated fatty acids. The fatty acids of the w3 series increased indifferently to the total fat and saturated fatty acids.Conclusions. Supplementing Nellore steers with energy and protein in this integrated crop-livestock system improved meat quality, as indicated by tenderness and marbling, and changed the fatty acid profile in a way that would be more attractive to consumers.Implications. The results of the experiment will guide ruminant nutritionists to define a supplement plan for finishing steers in Santa Fe integrated crop-livestock systems targeting healthier, high-quality, and sustainable meat markets.

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“…It is proposed that the lactate produced during exercise acts as a regulator of the accumulation of H + ions in the intramuscular space, because it is easily transported to the interstitial space or to the blood, captured by other cells, and metabolized in the Krebs cycle or in the gluconeogenic pathway. 37 Thus, the results found on the effects of GI in the pre-exercise meal on lactate levels seem irrelevant.…”

Section: Discussionmentioning

confidence: 99%

Influence of the Glycemic Index of Pre-exercise Meals in Sports Performance: A Systematic Review

2018

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Introduction: Carbohydrate (CHO) is essential for physical exercise. Some strategies for improving performance are based on the manipulation of the glycemic index (GI) of this nutrient during pre-exercise. Although several studies have been conducted on this subject, the use of low or high GI in a pre-exercise meal to improve performance remains undefined. Methods: In the present systematic review, the Pubmed (Medline) and Virtual Health Library databases were searched for randomized clinical trials conducted with healthy, physically active adults between 2006 and 2019, in which performance in addition to blood biochemical parameters, substrate utilization, body composition, perception of effort, and gastrointestinal symptoms were evaluated. The identified articles were independently and blindly evaluated by two authors, and any disagreements were resolved by a third investigator. Results: Five of the sixteen studies reviewed found differences in performance; of these, four were with low GI intervention. Few studies showed modifications in blood lactate and glucose levels beyond fatty free acid oxidation. No differences could be seen in the other parameters. The results as well as the methodologies used were heterogeneous; therefore, there are no clear advantages in determining the specific GI of the pre-exercise meal. Conclusions: There is no evidence that the pre-exercise meal GI influences performance. The heterogeneity of the studies precludes further conclusions.

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Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations

Cited by 129 publications

References 80 publications

Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols

Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols

Qualitative traits of the meat of Nellore steers supplemented with energy and protein in an integrated crop–livestock system

Influence of the Glycemic Index of Pre-exercise Meals in Sports Performance: A Systematic Review

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