Lactate and lactate dehydrogenase in predicting the severity of transient tachypnea of the newborn

Abstract

Lactate and LDH might be useful for clinicians at first level hospitals for decision making to refer the TTN patient to the secondary or tertiary level neonatal intensive care unit before the clinical situation is worsened.

Early Predictors of Transient Tachypnea of Newborn

“…In our study, we observed a high incidence of TTN neonates who were delivered by CS which is one of the most important risk factor of TTN and this results were in agreement with many other studies which also stated that most of the cases of TTN are born by CS [24][25][26][27][28].…”

“…In our study, we observed a significant increase in the levels of lactate and LDH levels in neonates with TTN which is predisposed by perinatal hypoxia in comparison with the neonates in the control group and this in agreement with studies done on Lactate dehydrogenase in predicting hypoxic ischemic encephalopathy in newborn infants [27,9].…”

Platelet mass index and prediction of severity of transient tachypnea of the newborn

“…Transient tachypnea of the newborn may lead to hypoxia and further morbidities in the neonates, and mild asphyxia may cause pulmonary capillary leak syndrome . Two studies that investigated the association between asphyxia and TTN evaluated the role of asphyxia determinants (lactate dehydrogenase [LDH], lactate, and ischemia‐modified albumin [IMA]) to predict severity of TTN.…”

Transient tachypnea of the newborn: are there bedside clues for predicting the need of ventilation support?

“…TTN is generally a benign disease and treated with a brief course of oxygen. However, some of the cases need invasive or non-invasive respiratory support 6,7,11,12 .…”

“…Delayed resorption of lung fluid is the main pathophysiological factor [4][5][6] . The factors associated with TTN are low gestational age, male gender, low birth weight, cesarean section (CS), low APGAR scores, maternal asthma, maternal sedation and perinatal asphyxia 1,3,5,[7][8][9][10] . TTN is generally a benign disease and treated with a brief course of oxygen.…”