Lactate Albumin Ratio Is Associated With Mortality in Patients With Moderate to Severe Traumatic Brain Injury

Wang, Ruoran; He, Min; Qu, Fengyi; Zhang, Jing; Xu, Jianguo

doi:10.3389/fneur.2022.662385

Cited by 12 publications

(11 citation statements)

References 51 publications

(61 reference statements)

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“…The L/A ratio is highly effective than lactate alone in forecasting 28-day death, according to the biggest retrospective analysis conducted by Gharipour et al [40] (AUC: 0.69 vs. 0.67, respectively). All these findings in this research are consistent with several studies examining the significance of the L/A ratio in a variety of illnesses, which also included sepsis in a prospective study of 155 patients, heart failure in a retrospective study of 4562 patients, and brain injury due to trauma in a retrospective study of 273 patients [41][42][43]. This study showed, that the L/A ratio was a reliable indicator for predicting deaths.…”

Section: Discussionsupporting

confidence: 91%

Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis

Kabra¹,

Acharya²,

Shukla³

et al. 2023

Cureus

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Aim: The aim of this study is to assess the efficacy of the serum lactate/albumin (L/A) ratio as a prognostic marker of sepsis syndrome.Materials and methods: This study was conducted in the Internal Medicine Department at Acharya Vinoba Bhave Rural Hospital with a sample size of 160 cases of sepsis. The serum L/A ratio was calculated on admission and correlated with deaths and morbidity. Statistical analysis was significant if the P-value was less than 0.05.Results: The mean age of patients was 52.83 ± 16.80 years with a male predominance (64.4% vs. 35.6%). The mean L/A ratio was 0.95 ± 0.46. The proportion of discharged subjects and mortality were 58.8% and 41.2%, respectively. The study found that a higher mean L/A ratio (1.1-1.44) was significantly linked to the various variables in the study. Furthermore, a significantly higher median L/A ratio of 1.23 was found in subjects with vasopressor use. The median L/A ratio in the Discharge group and Death group was 0.64 and 1.27, respectively. The area under the receiver operating characteristic (AUROC) curve indicated that accurate diagnostic performance was 0.976 in predicting Death versus Discharge for the L/A ratio.Conclusion: This study found that, compared to lactate and albumin alone, the predictor value of the L/A ratio was outstanding in predicting death and hospital stay (discharge) among sepsis participants, with a sensitivity of 100% and a specificity of 88%.

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Section: Discussionsupporting

confidence: 91%

Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis

Kabra¹,

Acharya²,

Shukla³

et al. 2023

Cureus

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“…The study suggests that clinicians can use a prognostic model that includes LAR to assess the probable progression and determine therapy decisions in traumatic brain injury patients. 36 …”

Section: Resultsmentioning

confidence: 99%

Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review

AL-shiakh

2023

SAGE Open Medicine

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Objective: In the Emergency Department, the physician’s purpose is to rapidly and accurately diagnose the severity of a patient’s condition so that proper treatment can be administered. Therefore, this study pays close attention to the association and prognostic value of blood lactate on different disease outcomes by systematically reviewing recently published studies. Methods: The search strategy was developed based on searches in the year 2022 for potential publications including original articles, case reports, and reviews using the following web databases google scholar, PubMed, and Science Direct. A total of 25 studies were identified and reviewed extensively to evaluate the link between mortality and serum lactate levels. Results: This literature review presents the strong association of elevated serum lactate levels with the in-hospital mortality rate among emergency department patients. Conclusion: These findings suggest that even a moderately raised lactate level in serum can predict the severe outcome in emergency department patients suffering from different conditions. Therefore, early (at the time of administration of hospital) and periodic serum lactate value determination through different techniques and scores is of need and should become part of routine analyses in emergency department to predict and choose therapies that could benefit critically ill patients.

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“…Recently, researchers explored the predictive value of LAR in the prognosis of neurosurgical diseases. For example, Wang et al's cohort study ( 12 ) on the mortality of patients with moderate to severe traumatic brain injury showed that non-survivors had higher LAR than survivors (1.09 vs . 0.53, P < 0.001), which was close to our results.…”

Section: Discussionmentioning

confidence: 99%

Association between lactate/albumin ratio and 28-day all-cause mortality in ischemic stroke patients without reperfusion therapy: a retrospective analysis of the MIMIC-IV database

Zhong,

Sun,

Chen

et al. 2023

Front. Neurol.

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ObjectiveThe lactate/albumin ratio (LAR) has been used as a novel prognostic indicator for aneurysmal subarachnoid hemorrhage, traumatic brain injury, sepsis, heart failure, and acute respiratory failure. However, its potential in predicting all-cause mortality in patients with ischemic stroke (IS) has not been evaluated. Therefore, this study aimed to elucidate the correlation between LAR and 28-day all-cause mortality in IS patients without reperfusion therapy.MethodsThis retrospective cohort study used data from the Medical Information Mart for Intensive Care (MIMIC-IV) (v2.0) database. It included 568 IS adult patients admitted to the intensive care unit (ICU). The correlation between LAR and ICU 28-day all-cause mortality rate was analyzed using multiple COX regression analysis and Kaplan–Meier survival analysis. Restricted cubic spline (RCS) curves were used to assess the relationship between LAR and 28-day mortality. In addition, a subgroup analysis was performed to investigate the impact of other influencing factors on outcomes. The primary outcome was the ability of LAR to predict 28-day mortality in IS patients.ResultsAmong the 568 patients with IS, 370 survived (survival group) and 198 died (non-survival group) within 28 days of admission (mortality rate: 34.9%). A multivariate COX regression analysis indicated that LAR was an independent predictor of all-cause mortality within 28 days after admission for patients with IS (hazard ratio: 1.32; 95% confidence interval: 1.03–1.68; P = 0.025). We constructed a model that included LAR, age, race, sex, white blood cell count, Sequential Organ Failure Assessment (SOFA) score, and anion gap (AG) and established a prediction model with an area under the curve (AUC) value of 71.5% (95% confidence interval: 67.1%−75.8%). The optimal cutoff value of LAR that separated the survival group and the non-survival group based on the Youden index was 0.55. The Kaplan-Meier survival curves plotted using this critical value showed that patients with LAR ≥ 0.55 had a significantly higher 28-day all-cause mortality rate than patients with LAR < 0.55 (P = 0.0083).ConclusionLAR can serve as an independent predictor of all-cause mortality within 28 days after admission for patients with IS.

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Lactate Albumin Ratio Is Associated With Mortality in Patients With Moderate to Severe Traumatic Brain Injury

Cited by 12 publications

References 51 publications

Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis

Serum Lactate-Albumin Ratio: Soothsayer for Outcome in Sepsis

Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review

Association between lactate/albumin ratio and 28-day all-cause mortality in ischemic stroke patients without reperfusion therapy: a retrospective analysis of the MIMIC-IV database

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