Lactase Deficiency in the Adult

Cuatrecasas, Pedro; Lockwood, Dean H.; Caldwell, JacquesR.

doi:10.1016/s0140-6736(65)90922-0

Cited by 246 publications

(52 citation statements)

References 45 publications

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“…The patient must of course be prepared to accept the discomforts and complaints that develop during the first 7-14 days of treatment (14). Adaptation is probably a more suitable therapy in cases of primary hypolactasia.…”

Section: Adaptation To Lactosementioning

confidence: 99%

Management of Lactose Intolerance

Tamm

1994

Scandinavian Journal of Gastroenterology

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Section: Adaptation To Lactosementioning

confidence: 99%

Management of Lactose Intolerance

Tamm

1994

Scandinavian Journal of Gastroenterology

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“…Neither exposure to extra lactose (12) (13) nor removal of lactose from the diet for periods of 40 to 50 days altered lactase levels in the intestinal tissues of adults. Perhaps of more significance, nine in a group of ten galactosemic children, ages 7 to 17 years, who had carefully avoided lactose-containing materials since early infancy, had normal blood glucose responses to oral lactose loads, suggesting that their lactase levels had not decreased during their long periods of lactose abstinence.…”

mentioning

confidence: 99%

The Metabolism of Lactose and Galactose

Hansen

Gitzelmann

1975

ACS Symposium Series

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Lactose, which is converted to galactose and glucose, is the primary carbohydrate source for developing mammals, and in humans it constitutes 40 percent of the energy consumed during the nursing period. Why lactose evolved as the unique carbohydrate of milk is un clear, especially since most individuals can meet their galactose need by biosynthesis from glucose. Whatever the rationale for lactose in milk, the occurrence of galactose in glyco-proteins, complex poly saccharides, and lipids, particularly in nervous tissue, has suggested specific functions. The organoleptic and physical properties of galac tose and, more specifically, the simultaneous occurrence of calcium and lactose in milk, may be significant evolutionary determinants.Lactose, in contrast to other saccharides, appears to enhance the absorption of calcium, as does vitamin D (1) (2). In man, calcium absorption is associated with the hydrolysis of lactose (3).The extensive literature concerned with galactose occurrence will not be reviewed, only some relevant examples will be cited. Col lagen contains glycosylated hydroxylysine, either as galactose or as glucosyl-galactose (4). Bone collagen mainly contains galactose mono saccharides, which could be important calcium binding centers, since many carbohydrates bind calcium in aqueous solution. In humans an excretion of three oligosaccharides containing galactose is enhanced by lactose ingestion (5). The three oligosaccharides appear to represent nonreducing terminals of the bloods antigenic determinants.

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“…Carefully documented studies, using radioiodinated albu¬ min and gamma globulin as well as 131I-labelled polyvinylpyrrolidone and 51Cr-labelled albumin, revealed that milk-containing diets produced a rapid loss of albumin, the half-life of the radio¬ iodinated albumin being less than four days. Recovery followed treatment with prednisone or the exclusion of milk from the diet; the loss of albumin subsided and the half-life of the radioiodinated albumin increased to between 10 and 16 days. Edsall and his group condemn such practices as the annual summer camp booster, and they believe that emergency boosters need not be given every time that an emergency arises.…”

mentioning

confidence: 99%