Lactase deficiency among Malaysian children with recurrent abdominal pain

Boey, Christopher Chiong Meng

doi:10.1046/j.1440-1754.2001.00622.x

Cited by 13 publications

(5 citation statements)

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“…This was an unexpected finding, since studies on non-autistic children involving patients of both sexes did not mention differences in lactase activity between boys and girls (Lebenthal et al, 1975;Gupta et al, 1999). A study on Malaysian children (Boey, 2001) demonstrated a similar proportion of boys and girls with lactase deficiency (71.4% and 70%, respectively). The biologic relevance for this observation is unclear and the small number of girls (n = 14) may have influenced statistical outcome.…”

Section: Discussionmentioning

confidence: 91%

Intestinal disaccharidase activity in patients with autism

Kushak

Lauwers

Winter

et al. 2011

Autism

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Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history.

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Section: Discussionmentioning

confidence: 91%

Intestinal disaccharidase activity in patients with autism

Kushak

Lauwers

Winter

et al. 2011

Autism

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“…(10,11) The most common carbohydrate is lactose, which is found in mammalian milk. The onset of lactose intolerance is insidious and the affected patients may not realise that lactose is the culprit of their abdominal pain, as the pain only appears a few hours after milk ingestion.…”

Section: Carbohydrate Intolerancementioning

confidence: 99%

Recurrent abdominal pain in children: a clinical approach

Sh¹

2015

smedj

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The term 'recurrent abdominal pain', or RAP, refers mainly to the duration of painful period and frequency of pain. The commonly accepted duration is at least three months in the preceding period, and over this three-month period, there are at least three episodes of pain that are severe enough to affect the daily activities of the affected patients. Over the years, with advances in medical technology and better understanding of the pathophysiology of abdominal pain, more and more organic causes have been identified. However, the most common cause of RAP in children is still functional in origin.

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“…A constipação intestinal funcional pode cursar com DAR, mas a sua relação com o hábito intestinal deverá contribuir para o diagnóstico e orientação do caso. Estudos controlados não demonstraram a associação entre DAR e deficiência de lactase, assim, dietas de exclusão, sem comprovação diagnóstica, devem ser evitadas 10,11,22 . Da mesma forma, mais recentemente, não foi comprovada a relação entre DAR e doença celíaca 23 .…”

Section: Dor Abdominal Recorrente -Darunclassified

Dores recorrentes na infância e adolescência

Puccini¹,

Bresolin²

2003

J. Pediatr. (Rio J.)

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ResumoObjetivo: realizar revisão bibliográfica sobre dores recorrentes na infância e na adolescência, com enfoque no diagnóstico diferencial e manejo desses pacientes. Fontes de dados: levantamento bibliográfico no Medline eLilacs, abrangendo os últimos quatro e dez anos, respectivamente, além de estudos e textos clássicos que tratam sobre o tema.Síntese dos dados: estudos realizados em diferentes partes do mundo demonstram que as dores recorrentes mais freqüentes na infância e adolescência são dor abdominal, cefaléia e dor em membros. A ocorrência de causa orgânica é baixa, observada em 5% a 10% dos casos. Dentre as causas orgânicas bem definidas de dor abdominal recorrente, cefaléia e dor em membros, não se observa nenhuma etiologia predominante. Foram analisados os principais avanços quanto à fisiopatologia das dores recorrentes, nas suas diferentes localizações, apresentando-se uma orientação para abordagem diagnóstica e terapêutica das afecções mais freqüentes em pediatria.Conclusões: as dores recorrentes na infância e adolescência são muito freqüentes e determinam significativa demanda aos serviços de saúde. A anamnese, o exame físico e o seguimento do paciente constituem a base para abordagem dessas crianças e adolescentes.J Pediatr (Rio J) 2003;79(Supl.1):S65-S76: dor, dor abdominal, cefaléia, dor em membros. AbstractObjective: to perform a bibliographic review of recurrent pain in children and adolescents, focusing on differential diagnosis and management of such patients.Sources of data: search of Medline and Lilacs databases, covering the last four and ten years, respectively. Classical studies and texts related to the matter were also included.Summary of the findings: studies carried out in different parts of the world demonstrate that the most frequent kinds of recurrent pain in children and adolescents are abdominal pain, headache, and limb pain. The occurrence of organic etiology is low, observed in 5% to 10% of the cases. Among the well defined organic etiology, no predominance is observed. The main advances regarding the pathophysiology of recurrent pain in its main localizations were analyzed. Guidelines for the diagnostic and therapeutic approach of the most common infantile diseases related to recurrent pain are presented.Conclusions: recurrent pain in children and adolescents is very common and determines significant demand on healthcare services. Defined etiology is only presented by 5% to 10% of patients. Anamnesis, physical examination and follow-up are extremely important instruments for dealing with such patients. Dores recorrentes na infância e adolescênciaRecurrent pain in children and adolescents Considerações geraisVárias afecções dolorosas, de evolução aguda ou crôni-ca, podem acometer a criança, gerando sofrimento e importante demanda aos serviços de saúde. Muitos fatores modificam a expressão da dor na criança, como idade, sexo, nível cognitivo -percepção que a criança tem da dor -, experiências dolorosas prévias, aprendizado, padrões culturais, relações familiares e comportame...

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Lactase deficiency among Malaysian children with recurrent abdominal pain

Abstract: The prevalence of lactase deficiency among this group of Malaysian children with recurrent abdominal pain was high, but lactase deficiency did not appear to play an important role in causing the symptoms.

Cited by 13 publications

References 13 publications

Intestinal disaccharidase activity in patients with autism

Intestinal disaccharidase activity in patients with autism

Recurrent abdominal pain in children: a clinical approach

Dores recorrentes na infância e adolescência

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