Lacrimal glands in cystic fibrosis

Alghadyan, Abdulrahman; Aljindan, Mohana; Alhumeidan, Adra; Kazi, Gholam; Mcmhon, Robert

doi:10.1016/j.sjopt.2013.01.001

Cited by 8 publications

(17 citation statements)

References 11 publications

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“…Further studies are needed in order to clarify potential alterations in LG morphology later in life. In a case report by Alghadyan et al 37 histopathologic examinations of LGs of CF patient who died of pulmonary complications revealed clogged small duct lumens and subsequent degeneration of acinar cells.…”

Section: Discussionmentioning

confidence: 97%

Novel Insight Into the Role of CFTR in Lacrimal Gland Duct Function in Mice

Berczeli

Vizvári

Katona

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PurposeThe role of cystic fibrosis transmembrane conductance regulator (CFTR) in lacrimal gland (LG) function has only recently received some attention, mainly from our group. In the present study, we investigated the potential changes of LG pathology, tear secretion, ocular surface integrity, and fluid secretion in isolated LG ducts from CFTR knockout (KO) mice.MethodsTear production and ocular surface integrity were investigated in anesthetized wild-type (WT) and KO mice using cotton threads and fluorescein staining, respectively. Immunofluorescence was used to localize CFTR protein in the LGs. Ductal fluid secretions evoked by forskolin (10 μM); cell-permeable cAMP analogue (8-bromo cAMP, 100 μM); or carbachol (100 μM) were measured in isolated LG ducts using video-microscopy. Intracellular Ca2+ homeostasis underlying carbachol stimulation was investigated with microfluorometry.ResultsSignificant decrease in tear secretion and impaired ocular surface integrity were observed in KO mice. Immunofluorescence demonstrated the predominant presence of CFTR protein in the apical membranes of the duct cells from WT mice. Continuous fluid secretion was evoked by forskolin and 8-bromo cAMP in LG ducts from WT mice, while no secretory response was observed in ducts from KO mice. Carbachol caused similar secretory responses in ducts from WT and KO animals without significant differences in cytosolic Ca2+ signaling.ConclusionsOur results suggest the important role of CFTR in LG ductal secretion and in the maintenance of ocular surface integrity, suggesting that CFTR may be a promising target of novel therapeutic approaches in the treatment of dry eye.

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Section: Discussionmentioning

confidence: 97%

Novel Insight Into the Role of CFTR in Lacrimal Gland Duct Function in Mice

Berczeli

Vizvári

Katona

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…Pharmaceutics 2021, 13, x 7 of 16 cluding xerophthalmia, papilledema, and retinal hemorrhages [51]. Joshi et al [52] reported the first case of newly diagnosed CF-related liver disease in a teenage boy presenting symptoms of night blindness secondary to vitamin A deficiency.…”

Section: Ocular Disorders Derived From Cystic Fibrosis Diseasementioning

confidence: 99%

“…Currently, eye manifestations of CF are less well known; however, mounting evidence suggests that ocular disorders in CF are a serious problem. A number of ocular disorders derived from CF have been reported, including xerophthalmia, papilledema, and retinal hemorrhages [ 51 ]. Joshi et al [ 52 ] reported the first case of newly diagnosed CF-related liver disease in a teenage boy presenting symptoms of night blindness secondary to vitamin A deficiency.…”

Section: Ocular Disorders Derived From Cystic Fibrosis Diseasementioning

confidence: 99%

Advantages and Disadvantages of Using Magnetic Nanoparticles for the Treatment of Complicated Ocular Disorders

Schneider‐Futschik

Reyes-Ortega

2021

Pharmaceutics

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Nanomaterials provide enormous opportunities to overcome the limitations of conventional ocular delivery systems, such as low therapeutic efficacy, side effects due to the systemic exposure, or invasive surgery. Apart from the more common ocular disorders, there are some genetic diseases, such as cystic fibrosis, that develop ocular disorders as secondary effects as long as the disease progresses. These patients are more difficult to be pharmacologically treated using conventional drug routes (topically, systemic), since specific pharmacological formulations can be incompatible, display increased toxicity, or their therapeutic efficacy decreases with the administration of different kind of chemical molecules. Magnetic nanoparticles can be used as potent drug carriers and magnetic hyperthermia agents due to their response to an external magnetic field. Drugs can be concentrated in the target point, limiting the damage to other tissues. The other advantage of these magnetic nanoparticles is that they can act as magnetic resonance imaging agents, allowing the detection of the exact location of the disease. However, there are some drawbacks related to their use in drug delivery, such as the limitation to maintain efficacy in the target organ once the magnetic field is removed from outside. Another disadvantage is the difficulty in maintaining the therapeutic action in three dimensions inside the human body. This review summarizes all the application possibilities related to magnetic nanoparticles in ocular diseases.

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“…The analyte concentrations in tears and biomedical component characteristics for human eyes are confined within normal ranges [39][40][41][42][43][44][45][46][47] in healthy individuals. When the analyte concentration is beyond the specific range (Table I), this leads to related diseases [48][49][50][51][52]. Therefore, multiple biomarkers in tear fluids may be used for disease screening.…”

Section: Introductionmentioning

confidence: 99%

Wireless Communication and Power Harvesting in Wearable Contact Lens Sensors

et al. 2021

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The human eye contains multiple biomarkers related to various diseases, making electronic contact lens an ideal non-invasive platform for their diagnosis and treatment. Recent advances in technology have enabled the monitoring and diagnosis of glaucoma from Intraocular Pressure (IOP) detection, diabetes from glucose concentration detections, and other biosensors for pH and temperature sensing. Different sensor designs have led to distinct power transfer techniques, among which inductively coupled power transfer is considered most favourable for electronic contact lenses power delivery applications. Therefore, loop antenna, spiral shape antenna, and antenna with nanomaterials such as graphene and hybrid silver nanofibers have been explored under Industrial, Scientific, and Medical (ISM) frequency bands for both Wireless Power Transfer (WPT) and data communication. Notably, spiral antennas are also considered as the component of IOP sensing using capacitive sensors to detect the changes in frequency caused by pressure. This article reviews the stateof-the-art technologies in electronic contact lens sensors and their power delivery techniques. Herein, diverse sensing methods, materials, and power transfer techniques and the promising future trends and challenges in electronic contact lenses have been presented.

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Lacrimal glands in cystic fibrosis

Cited by 8 publications

References 11 publications

Novel Insight Into the Role of CFTR in Lacrimal Gland Duct Function in Mice

Novel Insight Into the Role of CFTR in Lacrimal Gland Duct Function in Mice

Advantages and Disadvantages of Using Magnetic Nanoparticles for the Treatment of Complicated Ocular Disorders

Wireless Communication and Power Harvesting in Wearable Contact Lens Sensors

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