Lacrimal gland inflammation as the presenting sign of Crohn's disease

Hwang, Ivan P.; Jordan, David R.; Acharya, Virbala

doi:10.1016/s0008-4182(01)80043-0

Cited by 29 publications

(10 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inflammatory disease of the lacrimal gland may also present in a subacute or chronic form in which a painless mass appears in the region of the lacrimal fossa. 7,23,35 Differential diagnosis of dacryoadenitis primarily includes idiopathic inflammation, infection, Sjogren's syndrome, sarcoidosis, lymphoma, and primary tumour of the lacrimal gland. Neuro-radiologic imaging may be helpful in that longitudinal enlargement and variable enhancement of the gland, with adjacent soft tissue inflammation, is observed in idiopathic inflammatory dacryoadenitis.…”

Section: Orbital Involvement In Oidmentioning

confidence: 99%

Orbital inflammatory disease: a diagnostic and therapeutic challenge

Gordon

2006

Eye

172

115

View full text Add to dashboard Cite

show abstract

Section: Orbital Involvement In Oidmentioning

confidence: 99%

Orbital inflammatory disease: a diagnostic and therapeutic challenge

Gordon

2006

Eye

172

115

View full text Add to dashboard Cite

show abstract

“…Spontaneous resolution or supportive treatment with acetylsalicylic acid alone has been shown to arrest the disease in some patients. Thus, an initial observation with supportive treatment for the pain should also be considered (8,9). However, a more intensive regimen including biological agents for recalcitrant disease may be required to control recurrence in the course of reducing corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Adult-onset Still's Disease with Orbital Inflammatory Lesions Originating from the Lacrimal Gland

et al. 2015

View full text Add to dashboard Cite

Orbital inflammation has been rarely associated with adult-onset Still's disease (AOSD). We herein describe two AOSD patients who developed lacrimal gland enlargement with inflammation spreading to the contiguous tissues in the orbit. Case 1 was a 26-year-old woman who developed bilateral eyelid swelling while taking prednisolone (22.5 mg/day) for AOSD. The swelling of the eyelid worsened after other symptoms emerged, such as a fever, a rash, and arthritis. The laboratory findings, including leukocytosis, liver dysfunction, and ferritin elevation, also suggested an AOSD flare-up. Case 2 was a 62-year-old woman who presented with left eyelid swelling. She was diagnosed with AOSD at 45 years of age but sustained remission. During admission, she subsequently developed a fever, a rash, arthritis, lymphadenopathy, and ocular hyperemia. AOSD was suspected from the clinical course. We speculate that dacryoadenitis and orbital inflammation are manifestations of AOSD.

show abstract

“…The etiology of the high prevalence of dry eye symptoms in this population is unclear. Lacrimal gland inflammation has been associated with IBD, and objective evidence of reduced tear production is common [20,21]. …”

Section: Treatment-related Pathologiesmentioning

confidence: 99%

Managing IBD Outside the Gut: Ocular Manifestations

Calvo

Júlvez

2013

Dig Dis

View full text Add to dashboard Cite

Extraintestinal manifestations are common in inflammatory bowel disease (IBD), being reported in over 25% of patients. Ocular complications of IBD occur in around 10% of cases, but may precede systemic symptoms and are usually nonspecific. Complications of therapy, such as cataracts or glaucoma from steroid use or keratoconjunctivitis sicca related to 5-aminosalicylic acid medications, may also involve the eyes. The pathogenesis remains unclear, but factors such as the extent of intestinal disease, disease activity, and the presence of associated arthritis have been associated with ocular involvement. Conjunctivitis, episcleritis, scleritis and uveitis are by far the most common ophthalmic complications of IBD. However, posterior uveitis, intraretinal hemorrhages, vasculitis, choroiditis, optic neuropathy, and vaso-occlusive phenomena may also occur. The most frequent severe ocular manifestation is anterior uveitis (more common in women). It usually presents as a mild anterior nongranulomatous uveitis (60% of the cases). The inflammation in the eye and the inflammation in the gut are rarely correlated. Patients with uveitis, scleritis, and other anterior segment inflammation usually respond to steroids (topical, periocular or systemic). If the inflammation is resistant to steroids, or if appreciable steroid adverse effects are encountered, systemic immunosuppressive treatment should be considered; this is more likely in HLA-B27-positive patients with uveitis. Evaluation of the eye should be a routine component in the care of patients with IBD.

show abstract

Lacrimal gland inflammation as the presenting sign of Crohn's disease

Cited by 29 publications

References 3 publications

Orbital inflammatory disease: a diagnostic and therapeutic challenge

Orbital inflammatory disease: a diagnostic and therapeutic challenge

Two Cases of Adult-onset Still's Disease with Orbital Inflammatory Lesions Originating from the Lacrimal Gland

Managing IBD Outside the Gut: Ocular Manifestations

Contact Info

Product

Resources

About