Orbital inflammatory disease: a diagnostic and therapeutic challenge

Gordon, Lynn K.

doi:10.1038/sj.eye.6702383

Cited by 172 publications

(121 citation statements)

References 118 publications

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“…1 Subclassification can be based upon temporary course (acute or chronic), morphological classification (local or diffuse), or anatomical location. 2 Discrete and classifiable diseases can be implicated, but 5-8% 1,3 have no discernible cause on biopsy and hence labelled idiopathic orbital inflammation (IOI). This benign, non-infective syndrome was first described in 1903 4,5 and recognised as a specific clinicopathological entity of 'an orbital mass that simulated a neoplasm but was histologically inflammatory' in 1905.…”

Section: Introductionmentioning

confidence: 99%

Systemic immunoglobulin G4 (IgG4) disease and idiopathic orbital inflammation; removing ‘idiopathic’ from the nomenclature?

Lindfield

Attfield

McElvanney

2012

Eye

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Section: Introductionmentioning

confidence: 99%

Systemic immunoglobulin G4 (IgG4) disease and idiopathic orbital inflammation; removing ‘idiopathic’ from the nomenclature?

Lindfield

Attfield

McElvanney

2012

Eye

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“…While both primary and metastatic histiocytoid carcinomas of the eyelid and orbit are uncommon, other histiocytic lesions are not [55]. Noncancerous granuloma- tous lesions composed of histiocytes, potentially similar in appearance to histiocytoid carcinoma cells, can be seen in various processes including xanthelasma.…”

Section: Discussionmentioning

confidence: 99%

Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

et al. 2018

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Cutaneous histiocytoid carcinoma can occur as a primary tumor of the periocular region. Morphologically similar histiocytoid carcinomas arising as primary tumors of the breast have a predilection for orbital metastases. They can occasionally contain regions with prominent vacuolated cytoplasm and minimal nuclear atypia, which mimic benign histiocytic lesions. Differentiating nonneoplastic, primary neoplastic, and metastatic histiocytoid lesions involving the periorbita can be challenging for both the clinician and the pathologist, and this distinction has management implications. Herein, we present 3 cases to illustrate the challenges of diagnosing periocular histiocytoid carcinoma.

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“…Idiopathic orbital inflammatory pseudotumor (IOIP) is the third most common cause of unilateral exophthalmos in adults, accounting for 5-20% of orbital biopsies [3,7]. The exact etiology is unknown but may be related to an autoimmune disorder.…”

Section: Discussionmentioning

confidence: 99%

Concomitant Intraocular and Orbital Space-Occupied Lesions

Yan¹,

Shen²,

Chen³

2016

Optom open access

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Purpose/background: Concomitant intraocular and orbital space-occupied lesions are relatively rare and this is the first report stressing the underlying causes of concomitant intraocular and intraorbital lesions. In this paper, we present cases showing both intraocular and orbital soft tissue masses and highlight their clinical, pathological and imaging features. Materials and methods:A retrospective review was performed on cases with both intraocular and orbital spaceoccupied lesions who were treated at the Zhongshan Ophthalmic Center, of Sun Yat-sen University, China between Jan 1, 2000 and Dec 31, 2011. Results:From an initial retrospective review of 1543 patients with a diagnosis of intraocular and/or orbital spaceoccupied lesions, 8 patients (4 males and 4 females) with a coexistence of both intraocular and orbital mass lesions were identified. Patients' ages ranged from 22 months to 71 years (median = 3.0 years) and included 5 cases of retinoblastoma, 1 case of idiopathic inflammatory pseudotumor, 1 case of T-cell lymphoma, and 1 case of SturgeWeber syndrome.Conclusions: Based upon these findings, the presence of a lesion involving both the orbit and eye should be included when a diagnosis of retinoblastoma, idiopathic inflammatory pseudotumor, lymphoma, and/or SturgeWeber syndrome is proposed.

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Orbital inflammatory disease: a diagnostic and therapeutic challenge

Abstract: The spectrum of orbital inflammatory disease

Cited by 172 publications

References 118 publications

Systemic immunoglobulin G4 (IgG4) disease and idiopathic orbital inflammation; removing ‘idiopathic’ from the nomenclature?

Systemic immunoglobulin G4 (IgG4) disease and idiopathic orbital inflammation; removing ‘idiopathic’ from the nomenclature?

Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

Concomitant Intraocular and Orbital Space-Occupied Lesions

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