Lack of vasoactive intestinal polypeptide nerves in esophageal achalasia

Aggestrup, S; Uddman, Rolf; Sundler, F.; Fahrenkrug, Jan; Håkanson, R.; Sørensen, H.; Hambraeus, Göran

doi:10.1016/0016-5085(83)90192-0

Cited by 153 publications

(43 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The changes are accompanied by an inflammatory reaction both within and around the nerves. Neurochemical analysis has shown a reduction in the number of neurons in the myenteric plexus containing immunoreactive vasoactive intestinal polypeptide 2. The way in which the disease evolves remains unclear.…”

Section: Defects Of Innervationmentioning

confidence: 99%

Neurology and the gastrointestinal system

Perkin

Murray-Lyon

1998

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

The interrelation of neurology and the gastrointestinal system includes defects of gut innervation, primary disorders of the nervous system (or muscle) which lead to gastrointestinal symptoms-for example, dysphagia-and, finally, certain gut disorders which include neurological features in their clinical range. The first of this trio will be discussed only briefly in this review, the second and third in more detail.

show abstract

Section: Defects Of Innervationmentioning

confidence: 99%

Neurology and the gastrointestinal system

Perkin

Murray-Lyon

1998

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

show abstract

“…From a theoretical point of view oesophageal tonic activity could be altered in two possible ways: increased tone due to increased cholinergic activation8and decreased non-adrenergic, non-cholinergic inhibition9 10; and diminished tone due to increased compliance, in itself secondary to oesophageal dilatation.…”

mentioning

confidence: 99%

Oesophageal tone in patients with achalasia

González

Mearin

Vásconez

et al. 1997

Gut

View full text Add to dashboard Cite

Background-The diagnosis and classification of oesophageal motility disorders is currently based on assessment of the phasic contractile activity of the oesophagus. Tonic muscular contraction of the oesophageal body (oesophageal tone) has not been well characterised. Aim-To quantify oesophageal tonic activity in healthy subjects and in patients with achalasia. Patients-Oesophageal tone was measured in 14 patients with untreated achalasia and in 14 healthy subjects. In eight patients with achalasia, oesophageal tone was again measured one month after either endoscopic or surgical treatment. Methods-Tonic wall activity was quantified by means of a flaccid intraoesophageal bag, 5 cm long and of 120 ml maximal capacity, which was placed and maintained 5 cm above the lower oesophageal sphincter and connected to an external electronic barostat. The experimental design included measurement of oesophageal basal tone and compliance as well as the oesophageal tone response to a nitric oxide donor (0.5 ml amyl nitrite inhalation). Results-Oesophageal basal tone, expressed as the intrabag (intraoesophageal) volume at a minimal distending pressure (2 mm Hg), did not diVer significantly between patients with achalasia and healthy controls (6.6 (2.5) ml versus 4.1 (0.8) ml, respectively). Oesophageal compliance (volume/pressure relation during intraoesophageal distension) was significantly increased in achalasia (oesophageal extension ratio: 3.2 (0.4) ml/mm Hg versus 1.9 (0.2) ml/mm Hg; p< 0.01). Amyl nitrite inhalation induced oesophageal relaxation both in patients and in controls, but the magnitude of relaxation was greater in the latter (intrabag volume increase: 15.3 (2.4) ml versus 36.2 (7.1) ml; p<0.01). Conclusion-In patients with achalasia, oesophageal tonic activity, and not only phasic activity, is impaired. Although oesophageal compliance is increased, residual oesophageal tone is maintained so that a significant relaxant response may occur after pharmacological stimulation. (Gut 1997; 41: 291-296)

show abstract

“…Achalasia is an idiopathic motility disorder of the oesophagus characterized by an imbalance of the excitatory and inhibitory neuronal activities in the lower oesophageal sphincter 8 as the neurons containing inhibitory neurotransmitters such as nitric oxide and vasoactive intestinal peptide are absent in the region of the lower sphincter 9,10 .…”

Section: Discussionmentioning

confidence: 99%

Can a Warning Leak in a Patient with Unruptured Aneurysm Mask an Underlying Gastrointestinal Pathology?

Dc²,

Jw³

et al. 2008

Neuroradiol J

View full text Add to dashboard Cite

Aggravating headache accompanied by nausea and epigastric discomfort suggesting a warning leak in a 39-year-old woman with a giant thrombosed intracranial aneurysm prompted us to undertake coiling of the aneurysm. After uneventful coil embolization of the aneurysm, collapse of the lung related to bronchospam developed, and was found to have a gastrointestinal pathology which had gone undetected before the procedure. Despite its rarity, gastrointestinal pathology mimicking warning leak should have been considered in a patient with a warning leak sign.

show abstract

Lack of vasoactive intestinal polypeptide nerves in esophageal achalasia

Cited by 153 publications

References 12 publications

Neurology and the gastrointestinal system

Neurology and the gastrointestinal system

Oesophageal tone in patients with achalasia

Can a Warning Leak in a Patient with Unruptured Aneurysm Mask an Underlying Gastrointestinal Pathology?

Contact Info

Product

Resources

About