Lack of type 1 diabetes involvement in SARS-COV-2 population: Only a particular coincidence?

Pitocco, Dario; Tartaglione, Linda; Viti, Luca; Leo, Mauro Di; Manto, Andrea; Caputo, Salvatore; Pontecorvi, Alfredo

doi:10.1016/j.diabres.2020.108220

Cited by 24 publications

(23 citation statements)

References 3 publications

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“…Pitocco et al reported no cases of T1D in a sample of 1591 Italian subjects infected by SARS-CoV2. They suggested that age and adaptative immunity dysregulation could have influenced these results [19]. More recently, a study conducted in England, has evaluated the risk of death in type 1 and type 2 diabetes (T2D) patients hospitalized with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 lockdown on glycemic control in patients with type 1 diabetes

Fernández

Cortázar

Bellido

2020

Diabetes Research and Clinical Practice

132

121

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Introduction: The COVID-19 pandemic has forced governments to take exceptional measures to minimize its spread, imposing lockdown policies. The aim of this study was to evaluate the impact of lockdown on type 1 diabetes (T1D) glycemic control. Material and methods: People with T1D using flash glucose monitoring were included. Data from the 14 days before lockdown were compared with data from the last 14 days after 8 weeks of lockdown. Results: A total of 307 patients were included (age 45.8 ± 12.6 years, 50.2% male, diabetes duration 21.1 ± 12.3 years). Only one patient had COVID-19 infection. Mean glucose decreased from 166.89 ± 29.4 to 158.0 ± 29.0 mg/dL and estimated HbA1c declined from 7.4 ± 1.0 to 7.1 ± 1.0% (54 ± 10.9 vs 57 ± 10.9 mmol/mol; p < 0.001). Time in range increased from 57.8 ± 15.8 to 62.46 ± 16.1%. Time in hyperglycemia > 180 mg/dL and >250 mg/dL decreased from 37.3 ± 1.9% to 32.0 ± 17.1% and from 13.0 ± 11.3 to 10.3 ± 10.6%, respectively; (p < 0.001). Time in hypoglycaemia <70 mg/dL increased from 4.9 ± 4.0% to 5.5 ± 4.4% (p < 0.001). No differences in time <54 mg/dl, coefficient of variation (CV%) or number of scans per day were found. Conclusion: Despite the limitations of lockdown, glycemic control improved in patients with T1D. These results suggest that having more time for self-management may help improve glycemic control in the short term.

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Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 lockdown on glycemic control in patients with type 1 diabetes

Fernández

Cortázar

Bellido

2020

Diabetes Research and Clinical Practice

132

121

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“…Earlier reports from Italy and China noticed a curious lack of people with T1DM in hospitalized cohorts of SARS-CoV-2, that made authors wonder if the immunological attributes of T1DM are in some way protective [ 41 , 42 ]. However, it is more plausible that lock-down measures with special directives of caution to people with pre-existing conditions like diabetes, fear of infection, more parental supervision while staying at home encouraged young people to avoid crowded places as well as take better care of their diabetes.…”

Section: Covid-19 and T1dm: Bidirectional Linkmentioning

confidence: 99%

New onset diabetes, type 1 diabetes and COVID-19

Boddu

Aurangabadkar

Kuchay

2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

159

170

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Background and aims New data has emerged regarding higher risk of coronavirus disease 2019 (COVID-19), and its severity and complications in patients with type 2 diabetes mellitus (T2DM). However, there is a dearth of evidence regarding type 1 diabetes mellitus (T1DM). This article explores the possibility of COVID 19 induced diabetes and highlights a potential bidirectional link between COVID 19 and T1DM. Methods A literature search was performed with Medline (PubMed), Scopus, and Google Scholar electronic databases till October 2020, using relevant keywords (COVID-19 induced diabetes; COVID-19 and type 1 diabetes; COVID-19 induced DKA; new-onset diabetes after SARS-CoV-2 infection) to extract relevant studies describing relationship between COVID-19 and T1DM. Results Past lessons and new data teach us that severe acute respiratory syndrome coronaviruses (SARS CoV-1, -2) can enter islet cells via angiotensin converting enzyme-2 (ACE-2) receptors and cause reversible β-cell damage and transient hyperglycemia. There have been postulations regarding the potential new-onset T1DM triggered by COVID-19. This article reviewed all the available evidence regarding the impact and interlink between COVID-19 and Τ1DM. We also intended to explore the mechanisms behind the viral etiology of Τ1DM. Conclusions SARS CoV-2 induces new-onset diabetes with diabetic ketoacidosis at presentation in several individuals. However, at present, there is no hard evidence that SARS CoV-2 induces T1DM. Long term follow-up of children and adults presenting with new-onset diabetes during this pandemic is required to fully understand the type of diabetes induced by COVID-19.

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“…In fact, from early reports, risk of Coronavirus Disease-19 (COVID-19) progression to severe disease was higher among adult with diabetes [ 1 ]. However, children and adolescent with type 1 diabetes mellitus (T1DM) do not show higher morbidity and mortality related to COVID-19 [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of lockdown during COVID-19 emergency on glucose metrics of children and adolescents with type 1 diabetes in Piedmont, Italy

Tinti¹,

Savastio

Grosso

et al. 2021

Acta Diabetol

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Lack of type 1 diabetes involvement in SARS-COV-2 population: Only a particular coincidence?

Cited by 24 publications

References 3 publications

Impact of COVID-19 lockdown on glycemic control in patients with type 1 diabetes

Impact of COVID-19 lockdown on glycemic control in patients with type 1 diabetes

New onset diabetes, type 1 diabetes and COVID-19

Impact of lockdown during COVID-19 emergency on glucose metrics of children and adolescents with type 1 diabetes in Piedmont, Italy

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