Lack of TGF-α and TGF-β1 synthesis by human eosinophils in chronic oral ulcers

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

“…Animal studies demonstrated a favorable wound healing response through the interaction between eosinophils and fibroblasts via transforming growth factor-α and transforming growth factor-β (TGF-α, TGF-β) [43]. It has been suggested that delayed healing of EU is due to lack of TGF-α and TGF-β release by infiltrating eosinophils [16]. EU is considered the counterpart of cutaneous CD30+ lymphoproliferative disease [12,44,45].…”

“…As this disorder is of great interest for several medical specialties, such as dermatologists, otolaryngologists and dentists, various daunting terms have been used to characterize this disorder. These include, ulcerated granuloma eosinophilicum diutinum of the tongue [1], a term that has been abandoned, EU [2,3,4,5,6], traumatic granuloma [7,8], eosinophilic granuloma [9,10], traumatic eosinophilic granuloma [11,12], ulcerative eosinophilic granuloma [13,14], traumatic ulcerative granuloma with stromal eosinophilia [15,16], traumatic eosinophilic ulcer [17,18], and a combination of these. Adding to this list, identical clinical features exclusively seen in nursing infants are known as Riga-Fede disease [19].…”

Eosinophilic Ulcer of the Tongue: A case report with immunohistochemical study.

“…Numerous capillaries lined by plump endothelial cells were noted throughout. Immunohistochemical studies have established that EU is characterized by a mixed population of CD 68-positive histiocytes , S-100 protein-positive cells , factor XIIIa-positive dendrocytes and CD3-or CD30-positive T lymphocytes ( 5,22,23,28,32,33 ) . Myofibroblasts , as noted in our present case, have been described in some lesions (22).…”

“…Recently, Elovic et al . (32) concluded that the lack of expression of transforming growth factors in eosinophils of EU may play a crucial role in the impaired healing, in contrast to normal wound healing. In summary, the importance of EU is that it can pose considerable problems diagnostically.…”

Traumatic Ulcerative Granuloma With Stromal Eosinophilia - An Oral Ulcer With Specific Histology

“…(6) The same entity in infants and neonates is called RIGA-FEDE disease, caused by repeated trauma from a natal tooth. This was initially described by Antonio Riga in 1881 (7) and F. Fede in 1890.…”