Lack of Progress in Early Diagnosis of Bladder Cancer

Araki, Motoo; Nieder, Alan M.; Manoharan, Murugesan; Yang, Yulong; Soloway, Mark S.

doi:10.1016/j.urology.2006.10.016

Cited by 24 publications

(14 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the proportion of people without disease who have a negative result) of >90% (Saad et al, 2002;Simon, et al, 2003), it has some important limitations: it has inadequate sensitivity, particularly in well or moderately differentiated tumours (McDonald et al, 2006). Studies have shown that this expensive test (Araki et al, 2007) provides little unique information leading to the diagnosis of bladder cancer (Hofland and Mariani, 2004) and at best its role is supportive. Studies have shown that this expensive test (Araki et al, 2007) provides little unique information leading to the diagnosis of bladder cancer (Hofland and Mariani, 2004) and at best its role is supportive.…”

Section: Urine Cytologymentioning

confidence: 99%

“…Additionally, high rates of atypia are reported in patients with benign pathologies such as those with inflammation, stones or indwelling catheters; there is dependence on experienced cytopathologists and the results can be subjective (Grossman et al, 2005). Studies have shown that this expensive test (Araki et al, 2007) provides little unique information leading to the diagnosis of bladder cancer (Hofland and Mariani, 2004) and at best its role is supportive. Additionally, it takes around a week before the results are available and, therefore, delays diagnosis.…”

Section: Urine Cytologymentioning

confidence: 99%

See 1 more Smart Citation

Urine cytology is an unnecessary expense in the evaluation of adult haematuria

Turner

Allchorne

Pati

et al. 2009

Int J of Uro Nursing

View full text Add to dashboard Cite

Patients with microscopic and macroscopic haematuria undergo a series of investigations: the upper tracts are investigated with radiological investigations, the lower urinary tract with cystoscopy; urine is sent for microscopy, culture and sensitivity and cytological analysis. The aim of this study is to evaluate the role of urine cytology in adult patients with haematuria. A total of 6060 voided urine cytology specimens obtained from adults over the age of 18 who presented with haematuria in a single centre. Of the 6060 specimens sent for analysis, 5893 (97%) were reported to be benign, and 167 (3%) were not benign. Further analysis of the non‐benign results revealed 69 (41·3%) incomplete records and patients excluded. Of the 98 remaining results 34 (34·7%) were reported as repeat sample required; 44 (44·9%) were reported as suspicious for malignancy and 20 (20·4%) were reported as diagnostic. A total of 41 patients were finally diagnosed with cancer. All patients diagnosed with cancer were diagnosed on imaging or cystoscopy regardless of urine cytology result. This study has shown that urine cytology offers no unique information to adult patients being investigated for haematuria. It remains an expensive test and delays the haematuria pathway.

show abstract

Section: Urine Cytologymentioning

confidence: 99%

Section: Urine Cytologymentioning

confidence: 99%

Urine cytology is an unnecessary expense in the evaluation of adult haematuria

Turner

Allchorne

Pati

et al. 2009

Int J of Uro Nursing

View full text Add to dashboard Cite

show abstract

“…1 However, these techniques are costly and time consuming for both hospitals and patients. In addition, most of these diagnostic tools require the expertise of a cytopathologist, radiologist (e.g., intravenous urography, computed tomography and magnetic resonance urography), or urologist (e.g., cystoscopy).…”

Section: Introductionmentioning

confidence: 99%

“…This approach is the underlying reason for a "lack of progress" in the early diagnosis of bladder cancer. 1 A delay in the detection of invasive bladder cancer increases the risk of bladder cancer death. 2 Therefore, it is crucial to develop an inexpensive, noninvasive, highly sensitive, rapid, and easily automated technique to diagnose bladder cancer in its early stages.…”

Section: Introductionmentioning

confidence: 99%

Modulated Raman spectroscopy for enhanced identification of bladder tumor cells in urine samples

et al. 2011

View full text Add to dashboard Cite

Abstract. Standard Raman spectroscopy (SRS) is a noninvasive technique that is used in the biomedical field to discriminate between normal and cancer cells. However, the presence of a strong fluorescence background detracts from the use of SRS in real-time clinical applications. Recently, we have reported a novel modulated Raman spectroscopy (MRS) technique to extract the Raman spectra from the background. In this paper, we present the first application of MRS to the identification of human urothelial cells (SV-HUC-1) and bladder cancer cells (MGH) in urine samples. These results are compared to those obtained by SRS. Classification using the principal component analysis clearly shows that MRS allows discrimination between Raman spectra of SV-HUC-1 and MGH cells with high sensitivity (98%) and specificity (95%). MRS is also used to distinguish between SV-HUC-1 and MGH cells after exposure to urine for up to 6 h. We observe a marked change in the MRS of SV-HUC-1 and MGH cells with time in urine, indicating that the conditions of sample collection will be important for the application of this methodology to clinical urine samples. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

show abstract

“…This could have several explanations, among them the exclusion of ‘good‐risk’ patients receiving intravesical therapy and never needing cystectomy. Another study compared stage and survival in two consecutive cystectomy groups operated between 1992 and 2005 at one hospital, finding no improvement in either variable [2].…”

Section: Introductionmentioning

confidence: 99%

Why Has the Survival of Patients With Bladder Cancer Not Improved?

Malmström¹

2007

BJU International

View full text Add to dashboard Cite

Lack of Progress in Early Diagnosis of Bladder Cancer

Cited by 24 publications

References 28 publications

Urine cytology is an unnecessary expense in the evaluation of adult haematuria

Urine cytology is an unnecessary expense in the evaluation of adult haematuria

Modulated Raman spectroscopy for enhanced identification of bladder tumor cells in urine samples

Why Has the Survival of Patients With Bladder Cancer Not Improved?

Contact Info

Product

Resources

About