Lack of nasal carriage of novel corona virus (HCoV-EMC) in French Hajj pilgrims returning from the Hajj 2012, despite a high rate of respiratory symptoms

Gautret, Philippe; Charrel, Rémi N.; Belhouchat, Khadidja; Drali, Tassadit; Benkouiten, Samir; Nougairède, Antoine; Zandotti, Christine; Memish, Ziad A.; Masri, Malak al; Gaillard, Catherine; Brouqui, Philippe; Parola, Philippe

doi:10.1111/1469-0691.12174

Cited by 79 publications

(86 citation statements)

References 9 publications

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“…However, a strength of our study is that we tested almost 1000 children hospitalized with ARI symptoms for MERS-CoV. Of note, another study described lack of detecting MERS-CoV from nasal swabs from a group of French Hajj pilgrims after returning to France, despite a high rate of respiratory symptoms [15]. …”

Section: Discussionmentioning

confidence: 99%

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012

Khuri‐Bulos

Payne

et al. 2014

Clinical Microbiology and Infection

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Hospitalized children < 2 years of age in Amman, Jordan, admitted for fever and/or respiratory symptoms, were tested for Middle East respiratory syndrome coronavirus (MERS-CoV): MERS-CoV by real-time RT-PCR (rRT-PCR). This was a prospective year-round viral surveillance study in children <2 years of age admitted with acute respiratory symptoms and/or fever from March 2010 to September 2012 and enrolled from a government-run hospital, Al-Bashir in Amman, Jordan. Clinical and demographic data, including antibiotic use, were collected. Combined nasal/throat swabs were collected, aliquoted, and frozen at −80°C. Specimen aliquots were shipped to Vanderbilt University and the Centers for Disease Control and Prevention (CDC), and tested by rRT-PCR for MERS-CoV. Of the 2433 subjects enrolled from 16 March 2010 to 10 September 2012, 2427 subjects had viral testing and clinical data. Of 1898 specimens prospectively tested for other viruses between 16 March 2010 and 18 March 2012, 474 samples did not have other common respiratory viruses detected. These samples were tested at CDC for MERS-CoV and all were negative by rRT-PCR for MERS-CoV. Of the remaining 531 samples, collected from 19 March 2012 to 10 September 2012 and tested at Vanderbilt, none were positive for MERS-CoV. Our negative findings from a large sample of young Jordanian children hospitalized with fever and/or respiratory symptoms suggest that MERS-CoV was not widely circulating in Amman, Jordan, during the 30-month period of prospective, active surveillance occurring before and after the first documented MERS-CoV outbreak in the Middle East region.

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Section: Discussionmentioning

confidence: 99%

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012

Khuri‐Bulos

Payne

et al. 2014

Clinical Microbiology and Infection

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“…Nonetheless, the Saudi Arabian MOH confirmed that admissions of respiratory cases to Hajj hospitals had been within the expected range for the 2012 Hajj. Respiratory tract swabs of hospitalized patients-190 from Medina hospitals and another 86 from Mecca hospitals -tested negative for nCoV molecular targets, as did swabs from 154 pilgrims tested on return home to France [10]. More recently the Saudi Arabian MOH, through its leadership of the newly established collaborating Centre for Mass Gatherings Medicine, will conduct cross-sectional and longitudinal studies on nCoV and other respiratory tract infections for surveillance, prevention and control.…”

Section: Hajj Studies and Collaborationsmentioning

confidence: 99%

Saudi Arabia and the emergence of a novel coronavirus

Memish¹,

Al-Hakeem²,

Stephens³

2013

East Mediterr Health J

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“…Surveillance efforts, since the discovery of the virus and retrospective testing of stored respiratory specimens suggest this is not the case (Gautret et al, 2013). In August, 2013, the possible source of MERS-COV virus was traced to an Egyptian tomb bat found in a building, in close proximity to an index patient home.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological investigation of Middle East respiratory syndrome corona virus (mers-cov) among dromedary camels in selected areas of Afar and Oromia region, Ethiopia

Fekadu¹,

Ayelet²,

Abunna³

2017

J. Vet. Med. Anim. Health

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A cross-sectional study was conducted between October 2014 and May 2015, to determine the seroprevalence, assess the presence of active cases through isolation and identify possible risk factors for the Middle East Respiratory Syndrome Corona Virus (MERS-CoV) in camels, in selected areas of Oromia and Afar regional states of Ethiopia. A total of 569 dromedary camel sera were collected and screened with two serological tests: Pseudo particle neutralization for screening and Microneutralization test for confirmation. The overall prevalence of MERS-CoV in the study area was 93% (n=529). Higher prevalence (93.9%) was recorded in female dromedary camels compared to males (91.3%) but the difference was not significant (Chi-Square=1.323 and P=0.250). Age wise prevalence was higher in adult camels (94.6%) than young ones (90.8%), however the difference was statistically insignificant (Chi-Square=3.068 and P=0.080). Similarly, higher prevalence was recorded in larger herds (93.4%) than small herds but the difference observed was not statistically significant (Chi-Square=0.220 and p=0.639). Also, no significant (Chi-Square 0.525 and P=0.469) difference was observed in prevalence between the two regions (Oromia=93.3% and Afar=93.3%). However significant difference was observed in the lower administrations of the regions (Zones, District and Kebeles) in which the highest prevalence recorded in East Shoa, Fentale district of Adis Ketema kebele (99.3%). From total of 100 swabs collected, MERS-CoV was detected in seven (1 Fentale, 4 Amibara and 2 Dubti) districts by Real-time reverse transcription polymerase chain reaction (RT-PCR). Generally, this study showed the existence of high seroprevalence of MERS-CoV among Ethiopian dromedary camels, which was also confirmed by RT-PCR. Therefore further study is required to determine its significance from both animal and public health perspectives and further research should focus on identifying similarity between MERS-CoV viral isolates in neighboring countries and clinical isolates from the Middle East and elsewhere.

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Lack of nasal carriage of novel corona virus (HCoV-EMC) in French Hajj pilgrims returning from the Hajj 2012, despite a high rate of respiratory symptoms

Cited by 79 publications

References 9 publications

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012

Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012

Saudi Arabia and the emergence of a novel coronavirus

Epidemiological investigation of Middle East respiratory syndrome corona virus (mers-cov) among dromedary camels in selected areas of Afar and Oromia region, Ethiopia

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