Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats

Takagi, Hironori; Shibutani, Makoto; Lee, Kyoung-Youl; Lee, Hwi Cheul; Nishihara, Masugi; Uneyama, Chikako; Takigami, Shu; Mitsumori, Kunitoshi; Hirose, Masao

doi:10.1016/j.reprotox.2004.03.002

Cited by 21 publications

(31 citation statements)

References 39 publications

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“…The conflict in 14 results between our study and the findings reported by Ball et al may be due to different learning mechanisms. The water maze is a learning paradigm characterized by a motivation to escape from water, whereas the MAZE test used in the current study is a learning paradigm characterized by motivation to receive a reward.…”

Section: Discussioncontrasting

confidence: 99%

“…For example, male rats exposed to GEN during pre-or post-natal periods have been reported to exhibit demasculization or decreased reproductive behavior in adulthood [11,12]. Additionally, perinatal or neonatal exposure to GEN in female rats, has been shown to cause irregular estrous cyclicity and histological changes in the ovaries, uterus, and mammary glands [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

Kohara

Kuwahara

Kawaguchi

et al. 2014

Physiology & Behavior

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This study investigated the effects of perinatal genistein (GEN) exposure on the central nervous system of rat offspring. Pregnant dams orally received GEN (1 or 10 mg/kg/day) or vehicle (1 ml/kg/day) from gestation day 10 to postnatal day 14. In order to assess the effects of GEN on rat offspring, we used a battery of behavioral tests, including the open-field, elevated plus-maze, MAZE and step-through passive avoidance tests. MAZE test is an appetite-motivation test, and we used this mainly for assessing spatial learning and memory. In the MAZE test, GEN groups exhibited shorter latency from start to goal than the vehicle-treated group in both sexes. On the other hand, performances in the step-through passive avoidance test were non-monotonically inhibited by GEN in both sexes, and a significant difference was observed in low dose of the GEN-treated group compared to the vehicle-treated group in female rats. Furthermore, we found that perinatal exposure to GEN did not significantly alter locomotor activity or emotionality assessed by the open-field and elevated-plus maze tests. These results suggest that perinatal exposure to GEN improved spatial learning and memory of rat offspring, but impaired their passive avoidance learning and memory.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

Kohara

Kuwahara

Kawaguchi

et al. 2014

Physiology & Behavior

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“…Significantly reduced estradiol levels in rats fed 0.35 mg/kg body weight of genistein were reported by Awoniyi et al [27]. Estradiol did not change in rats fed 96 mg/kg body weight of genistein [28].…”

Section: Discussionsupporting

confidence: 49%

Associations among maternal soy intake, isoflavone levels in urine and blood samples, and maternal and umbilical hormone concentrations (Japan)

Nagata

Iwasa

Shiraki

et al. 2006

Cancer Causes Control

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AbsractObjectives In utero exposure to high levels of endogenous estrogens has been hypothesized to increase breast cancer risk in later life. A high intake of soy has been suggested to protect against breast cancer. We examined the hypothesis that maternal soy intake may be inversely associated with pregnancy hormone levels. Methods The concentrations of hormones (estradiol, estriol, and testosterone) and isoflavones (genistein, deidzein, and equol) were measured in the maternal urine and serum, and umbilical cord blood of 194 women during pregnancy and at delivery. Soy intake during pregnancy was assessed by 5-day diet records at approximately the 29th week of pregnancy. Results High correlations were observed for isoflavone levels between maternal samples and umbilical cord blood, indicating that isoflavone can be transferred from the maternal to the fetal compartment. None of the hormones measured in umbilical cord blood was significantly associated with any of the isoflavones measured. There were a few significant associations between maternal hormone levels and isoflavone measures during pregnancy, but their patterns of asso-

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“…Studies have found that phytoestrogens can cross the placental barrier in humans, and one study of Californian women undergoing amniocentesis found that 96% of second trimester amniotic fluid samples contained quantifiable amounts of dietary phytoestrogens (Foster et al, 2002). Additionally, as previously described, studies in rodents have found that exposure to high doses of isoflavones in utero and through diet in early life accelerated pubertal onset in female animals (Casanova et al, 1999; Takashima-Sasaki et al, 2006; Takagi et al, 2004; Kouki et al, 2003; Lewis et al, 2003; Bateman and Patisaul, 2008; Lee et al, 2009; Nagao et al, 2001). …”

Section: Discussionsupporting

confidence: 57%

“…In utero exposure to phytoestrogens are of particular interest because of the timing of differentiation and development (Casanova et al, 1999; Takashima-Sasaki et al, 2006; Takagi et al, 2004). Studies in rodents have found that isoflavones administered through diet or subcutaneous injection during gestation or early life can lead to early vaginal opening (akin to early menarche in humans), irregular estrous cyclicity, and decreased GnRH (gonadotropin-releasing hormone) activation (GnRH coordinates reproductive maturation and function) (Casanova et al, 1999; Takashima-Sasaki et al, 2006; Takagi et al, 2004; Kouki et al, 2003; Lewis et al, 2003; Bateman and Patisaul, 2008; Lee et al, 2009; Nagao et al, 2001). To date, few studies have examined the effects of lignan metabolites on pubertal development, particularly age at menarche (Kim and Park, 2012).…”

Section: Introductionmentioning

confidence: 99%

Exposure to phytoestrogens in utero and age at menarche in a contemporary British cohort

Marks

Hartman

Taylor

et al. 2017

Environmental Research

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Phytoestrogens are estrogenic compounds that occur naturally in plants. Phytoestrogens can cross the placenta, and animal studies have found associations between in utero exposure to phytoestrogens and markers of early puberty. We investigated the association between in utero exposure to phytoestrogens and early menarche (defined as < 11.5 years of age at onset) using data from a nested case-control study within the Avon Longitudinal Study of Parents and Children, a longitudinal study involving families living in the South West of England. Concentrations of six phytoestrogens were measured in maternal urine samples collected during pregnancy. Logistic regression was used to explore associations between tertiles of phytoestrogen concentrations and menarche status, with adjustment for maternal age at menarche, maternal education, pre-pregnancy body mass index (BMI), child birth order, duration of breastfeeding, and gestational age at sample collection. Among 367 mother-daughter dyads, maternal median (interquartile range) creatinine-corrected concentrations (in μg/g creatinine) were: genistein 62.1 (27.1–160.9), daidzein 184.8 (88.8–383.7), equol 4.3 (2.8–9.0), O-desmethylangolensin (O-DMA) 13.0 (4.4–34.5), enterodiol 76.1 (39.1–135.8), and enterolactone 911.7 (448.1–1558.0). In analyses comparing those in the highest tertile relative to those in the lowest tertile of in utero phytoestrogen exposure, higher enterodiol levels were inversely associated with early menarche (odds ratio (OR) = 0.47; 95% confidence interval (CI): 0.26–0.83), while higher O-DMA levels were associated with early menarche (OR = 1.89; 95% CI: 1.04–3.42). These findings suggest that in utero exposure to phytoestrogens may be associated with earlier age at menarche, though the direction of association differs across phytoestrogens.

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Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats

Cited by 21 publications

References 39 publications

Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

Associations among maternal soy intake, isoflavone levels in urine and blood samples, and maternal and umbilical hormone concentrations (Japan)

Exposure to phytoestrogens in utero and age at menarche in a contemporary British cohort

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