Lack of evidence of hepatic disease in patients with oral lichen planus in Serbia

Abstract

Patients with OLP resident in Serbia do not have evidence of chronic liver disease or infection with HBV or HCV. The exact aetiological role between hepatic disease and OLP remains unclear.

The Prevalence of Hepatitis C Virus Infection in Oral Lichen Planus in an Ethnic Chinese Cohort of 232 Patients

“…In Japan, Italy, Nigeria, Thailand (Nagao et al, 1995;Carrozzo et al, 1996;Figueiredo et al, 2002;Daramola et al, 2003;Klanrit et al, 2003;Lodi et al, 2004), the prevalence of HCV infection in OLP patients ranging from 8.33% to 60% was statistically higher than the controls. However, reports from other areas, such as Holland,Germany, Serbia, Rio de Janeiro (van der Meij et al, 2000;Friedrich et al, 2003;Bokor-Bratic et al, 2004;Cunha et al, 2005) showed no difference in the HCV infection rate between the patients with OLP and the common population. In this study, we investigated the prevalence of HCV in 232 ethnic Chinese OLP patients and no association was found between these two diseases.…”

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

“…Specifically, using the twenty-eight studies which were considered eligible by the reviewers, the pooled OR estimate was 4.8 (95CI 3.6-6.6). This value overestimated the OR that was obtainable from the underlying population of primary studies selected by the authors, because five studies, which reported zero values among exposed cases and controls [23,28,38,44,46], were excluded from the list of primary studies. Anyway, the pooled OR decreased to 3.9 (95CI 2.2-7.0) when the primary studies were restricted to those twelve with the lowest level of diagnostic bias, because they ruled out the possibility of misclassifications of drug-induced lichenoid reactions [70].…”

Hepatitis C Virus and Lichen Planus

“…To identify any study that may have exerted a disproportionate influence on the summary effect, we performed sensitivity analyses to further establish the robustness of our results by applying strict inclusion criteria. 45 The control populations included persons seeking evaluation on surgery, 13,31,56,58 patients with dermatoses other than LP treated at a department of dermatology, § patients with oral diseases, and persons who donated * References 16,17,21,22,26,[28][29][30][31][32]36,48,51,[53][54][55]58,61,63,66,71,74,75. 10 Figure 1 shows the flow of the search selection process for articles from the original sources to final acceptance for our review.…”

“…10 Figure 1 shows the flow of the search selection process for articles from the original sources to final acceptance for our review. References 17,30,36,37,39,41,54,59,61,62,66. blood, ¶ whereas the remainder included persons who were healthy.# Among the studies that reported age, the criterion was different, with the age for all participants ranging from 4 to 97 years. After excluding irrelevant studies by screening their titles and abstracts and eliminating uncontrolled case series, duplicate publications, and review articles by retrieving full texts, 55 articles were included.…”