Lack of evidence of any association between human herpesvirus 8 and various skin tumors from both immunocompetent and immunosuppressed patients

Prevalence of Human Herpesvirus 8 Infection Measured by Antibodies to a Latent Nuclear Antigen in Patients With Various Dermatologic Diseases

“…Some authors report that HHV-8 may be found in other dermatologic diseases, such as epithelial tumors, cutaneous T-cell lymphoma, or pemphigus vulgaris, and that HHV-8 could be a widespread virus reactivated in some tumoral or immunological conditions. [3][4][5][6] However, we and others [7][8][9][10][11] have not confirmed the presence of HHV-8 in lymphoproliferative disorders of the skin or in epithelial tumors either in immunocompetent or immunosuppressed patients. Such discrepancies could reflect the variation of the distribution of HHV-8 infection by geographical area.…”

“…3,6 However, these results have not been confirmed by other reports. 7,8 Concerning the role of HHV-8 in lymphoproliferative disorders of the skin, one study reported the presence of HHV-8 DNA sequences in 7 of 48 cutaneous T-cell lymphomas, including 2 cases of mycosis fungoides, 2 peripheral T-cell lymphomas, 2 cases of parapsoriasis en plaque, and 1 lymphomatoid papulosis. 4 These results were not confirmed in following studies, suggesting that HHV-8 is not directly implicated in the pathogenesis of either cutaneous T-cell or B-cell lymphoma.…”

Risk of malignant lymphoma associated with human herpesvirus-8: a case–control study in Spain

“…The association of HHV-8 with other lymphoproliferative disorders in non-HIVinfected subjects remains controversial (Mikala et al, 1999). In the absence of HIV, HHV-8 DNA has been detected in T-cell PEL cells (Lechapt-Zalcman et al, 2001) and in lymphoma cells with plasmacytic differentiation, but not in cutaneous T-and B-cell lymphoma (Dupin et al, 1997) or in mycosis fungoides (Henghold et al, 1997).…”

Efficacy of a Film-Forming Medical Device Containing Piroxicam and Sun Filters in the Treatment of Multiple Actinic Keratosis Lesions in a Subject with a History of Kaposi Sarcoma

“…Some experimental data have shown that the HHV8 virus can be isolated in more than 30% of the AK skin lesions [13]. However, these data were not confirmed by other authors [14]. In the present case report, we found that the use of a medical device containing piroxicam 0.8% and a sun filter with 50+ SPF in a subject with multiple AK lesions of the scalp, unresponsive to previous treatment and with a history of classic Kaposi sarcoma, was very effective and well tolerated.…”

“…Some experimental data have shown that AK lesions carry HHV8 in more than 30% of the bioptic samples [13]. However, these data were not confirmed by other authors [14]. Topical piroxicam was shown to be effective in the treatment of AK [15].…”