Lack of Enteral Feeding Increases Expression of E-Selectin after LPS Challenge

Fukatsu, Kazuhiko; Zarzaur, Ben L.; Johnson, Corey; Lundberg, Andrew H.; Hanna, M. Keith; Wilcox, Henry G.; Kudsk, Kenneth A.

doi:10.1006/jsre.2001.6109

Cited by 21 publications

(8 citation statements)

References 18 publications

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“…Adhesion molecule expressions on circulating lymphocytes and endothelial cells of mucosal lymphoid tissue regulate lymphocyte homing to the mucosal area (15,16). It is reasonable to speculate that gut I/R changed expressions of these adhesion molecules, just as various inflammatory stimuli can alter their expressions (17)(18)(19). Alternatively, a decrease in circulating lymphocytes might have reduced the degree of lymphocyte homing to GALT, although we did not evaluate lymphocyte numbers in peripheral blood.…”

Section: Discussionmentioning

confidence: 87%

Gut ischemia-reperfusion affects gut mucosal immunity: A possible mechanism for infectious complications after severe surgical insults*

Fukatsu

Sakamoto

Hara

et al. 2006

Critical Care Medicine

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Section: Discussionmentioning

confidence: 87%

Gut ischemia-reperfusion affects gut mucosal immunity: A possible mechanism for infectious complications after severe surgical insults*

Fukatsu

Sakamoto

Hara

et al. 2006

Critical Care Medicine

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“…54 Decreased permeability and enhancement of the immunologic function of the gut are reasons given for the decrease in septic complications seen with use of enteral nutrition compared with parenteral nutrition. 55 As FD&C Blue No. 1 was characterized as nonabsorbable, it did not seem to be contraindicated in these settings.…”

Section: Enteral Feeding and Blue Food Dye: A Surgical Perspectivementioning

confidence: 96%

Food Dye Use in Enteral Feedings: A Review and a Call for a Moratorium

Maloney

Ryan

Brasel³

et al. 2002

Nut in Clin Prac

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Pulmonary aspiration of gastric contents is common in enterally fed patients. Tinting enteral feedings with blue dye is thought to aid the early detection of aspiration in hospitalized patients. The blue-dye method is popular despite evidence that it is not sensitive. Reports of absorption of blue dye from enteral feedings in patients with sepsis and other critical illnesses are increasing. The presence of blue and green skin and urine, and serum discoloration has been linked with death. FD&C Blue No.1 and related dyes have toxic effects on mitochondria, suggesting that dye absorption is harmful. This study reviews the literature on the dye method and dye pharmacology, reports the results of a survey of current dye use, and describes 2 recent deaths associated with blue-dye absorption. We concluded that the use of blue dye in enteral feedings should be abandoned and replaced by evidence-based methods for the prevention of aspiration.

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“…After 15 minutes of ischemia, survival of animals fed via the GI tract with either chow or a CED administered through a gastrostomy tube is approximately 90%–95% at 72 hours. 127 PN, however, reduces survival to 50%. The expression of 2 PMN activation markers, CD11a and CD11b, were measured in blood samples following exposure to gut ischemia or reperfusion and samples of lung tissue were stained for CD18, a marker of myeloid activation using immunohistochemistry.…”

Section: Inflammation and Route Of Nutritionmentioning

confidence: 99%

“…The P- and E-selectins initiate rolling and adhesion of the PMNs to the vascular endothelium while firm attachment occurs between the ICAM-1 molecule and the PMN. 126,127 …”

Section: Inflammation and Route Of Nutritionmentioning

confidence: 99%