Lack of effect of pregnancy on outcome of melanoma

MacKie, Rona M.; Bufalino, Rosaria; Morabito, Alberto; Cascinelli, Natale; Sutherland, Carl M.; Kroon, Ben; Urist, Marshall M.; Lejeune, Ferdy J.; Hunter, John; Göhl, J.; Santi, Leonardo; Schmitt, Holger; Holmstrøm, Henrik; Woźniak, Katarzyna Maria; Wussow, Peter von; Craig, Paul; Aubert, Carole E.; Shibata, Hirotoshi; Priario, Julio C; Trapeznikov, N. N.; Durandi, J.; Bandiera, D. C.; Szekeres, E; Milton, G. W.; Avril, Marie-Françoise; Kułakowski, A; Panizzon, Renato G.

doi:10.1016/0140-6736(91)92462-b

Cited by 182 publications

(64 citation statements)

References 11 publications

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“…However, the literature concerning melanoma progression in pregnancy presents a complex picture (MacKie et al, 1991). Pregnancy is often associated with hyperpigmentation of the skin, clearly indicating an influence of steroids on melanocyte biology.…”

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confidence: 99%

Investigation of female survival benefit in metastatic melanoma

et al. 1999

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Summary Epidemiological studies show female survival benefit in advanced metastatic melanoma. In investigating a possible mechanism for this female survival benefit, we have previously reported that the female steroid 17β-oestradiol significantly reduces invasion of a human melanoma cell line (A375-SM cells) and ocular melanoma cells through fibronectin. Neither cell type was found to possess oestrogen receptor-α. The aim of the current study was to obtain further information on the extent to which progression of cutaneous melanoma might be sex steroid sensitive by (a) examining the relationship between circulating sex steroids, sex hormone binding globulin and disease progression; (b) examining the relationship between sex steroid structure and the ability of steroids to reduce invasion of a melanoma cell line in vitro; and (c) examining the effects of sex steroids on proliferation of these cells in vitro. We report a significant reduction in circulating oestrone with disease progression in male but not female patients. Examining steroids for their ability to inhibit invasion of A375-SM cells through fibronectin in vitro, oestrogenic compounds (17β-oestradiol and oestrone) were found to inhibit invasion; in this respect, oestrone was approximately 50 times more potent than 17β-oestradiol; steroids lacking the benzene ring structure did not inhibit invasion, indeed dehydroepiandrosterone (DHEA) which acts as a precursor to androgenic steroids significantly enhanced invasion. Proliferation of A375-SM cells was unaffected by 17β-oestradiol, oestrone or dihydrotestosterone when cells were cultured on plastic; in contrast, all three steroids induced modest proliferation of cells when grown on fibronectin with dihydrotestosterone the most mitogenic of the three steroids. These data are consistent with sex steroids playing a role in melanoma progression.Keywords: melanoma; invasion; oestrogen; testosterone; oestrogen receptor-β 2025British Journal of Cancer (1999) 80(12), 2025-2033 © 1999 Cancer Research Campaign Article no. bjoc.1999 Received 8 September 1998 Revised 19 February 1999 Accepted 23 February 1999 Correspondence to: S Mac Neil A375-SM cell line used in this study did not possess classical oestrogen receptors (oestrogen receptor-α) nor did the majority of melanoma tumours which we investigated (Dewhurst et al, 1997, and Miller et al, 1997, respectively).In the current study we have continued investigations of sex steroid status and tumour progression for a cohort of patients with advanced metastatic disease versus appropriately aged and sexmatched controls and we have investigated to what extent the antiinvasive effect of 17β-oestradiol is specific to oestrogenic steroids.We report a modest reduction in sex hormone binding globulin and oestrone with disease progression in male but not female patients. Examining a range of steroids for anti-invasive activity, we found oestrogenic compounds (17β-oestradiol and oestrone) to inhibit invasion; steroids lacking the benzene ring structure did not inhibit invas...

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confidence: 99%

Investigation of female survival benefit in metastatic melanoma

et al. 1999

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“…Earlier case reports raised concerns that a subsequent pregnancy may activate micrometatases from a previous melanoma based on the theoretical influence of pregnancy related hormones and growth factors (46,47). Larger cohort studies have not found that a subsequent pregnancy affects the outcome of a previously diagnosed melanoma (22,39,41).…”

Section: Melanoma Before Pregnancymentioning

confidence: 99%

“…Several studies of pregnant women with melanoma have demonstrated increased tumour thickness compared with non-pregnant controls (29,39). Some studies have found that melanomas occurring during gestation tend to occur on body sites associated with a worse prognosis such as head, neck, and trunk (17,26,37,39,40).…”

Section: Melanoma During Pregnancymentioning

confidence: 99%

“…There have been a handful of case reports, case series, (23,24,45) and some larger cohort studies (22,39,41) that have addressed this question with varied results. Earlier case reports raised concerns that a subsequent pregnancy may activate micrometatases from a previous melanoma based on the theoretical influence of pregnancy related hormones and growth factors (46,47).…”

Section: Melanoma Before Pregnancymentioning

confidence: 99%

“…Mackie et al (39) assessed a sub group of 85 patients who had been diagnosed with melanoma prior to becoming pregnant. They were compared to 143 patients who had completed all pregnancies prior to the diagnosis of melanoma.…”

Section: Melanoma Before Pregnancymentioning

confidence: 99%

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