Special Considerations for Stage IV Melanoma During Pregnancy

Small bowel obstruction: a recurrence of melanoma during the second trimester of pregnancy

“…In the past, most women diagnosed with metastatic melanoma during pregnancy have either delivered at term and had poor outcomes with mortality within 12 months from metastatic treatment refractory disease or opted for pregnancy termination. 7 There has been one previously published case report in which a woman was delivered prematurely at 28 weeks, received combination chemotherapy but died four months after delivery. Sadly, the baby died of septicemia at three months of age, a common complication of preterm delivery.…”

Cancer Treatment in Pregnancy

“…However, the management of advanced disease (stage III and IV) during pregnancy can be quite a dilemma, as the prognosis for these patients is poor. Traditional chemotherapeutic agents have not been shown to signifi cantly increase in survival for these patients, and their use during pregnancy needs to be considered carefully due to potential for adverse fetal effect [ 76 ]. Interferon has also been used in this setting, although the potential for severe toxicity limits its use during pregnancy.…”

Molecular histology on the diagnostic cutting edge between malignant melanomas and cutaneous melanocytomas (Review)

“…Examples are melanocytomas developed on congenital naevi, dysplastic naevi (33), naevi modified by pregnancy or oral contraception (34), naevi of subjects on growth hormone therapy (15), naevi under ultraviolet-light irradiation (35,36). It should be mentioned that some of these lesions mimick MM or are at risk for MM development (37). The possibility of a melanocytoma should be evoked in each single case.…”