Special Considerations for Stage IV Melanoma During Pregnancy

Metastatic amelanotic nodular melanoma during pregnancy

“…Pregnancy may be terminated or continued, and the management planned accordingly. Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our and other reported cases (13). Such patients seem to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.…”

“…The wish to have a healthy child meets the potentially deadly cancer disease. Some recently published cases as well as our case illustrate that management of advanced disease during pregnancy is more complicated and meets a conflict between optimal maternal therapy and fetal or neonatal well being (13,16,25). Therapeutic, familial, and social considerations must be addressed and decided in an individualized manner.…”

Metastatic amelanotic nodular melanoma during pregnancy

“…Pregnancy may be terminated or continued, and the management planned accordingly. Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our and other reported cases (13). Such patients seem to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.…”

“…The wish to have a healthy child meets the potentially deadly cancer disease. Some recently published cases as well as our case illustrate that management of advanced disease during pregnancy is more complicated and meets a conflict between optimal maternal therapy and fetal or neonatal well being (13,16,25). Therapeutic, familial, and social considerations must be addressed and decided in an individualized manner.…”

Small bowel obstruction: a recurrence of melanoma during the second trimester of pregnancy

“…In the past, most women diagnosed with metastatic melanoma during pregnancy have either delivered at term and had poor outcomes with mortality within 12 months from metastatic treatment refractory disease or opted for pregnancy termination. 7 There has been one previously published case report in which a woman was delivered prematurely at 28 weeks, received combination chemotherapy but died four months after delivery. Sadly, the baby died of septicemia at three months of age, a common complication of preterm delivery.…”

Spontaneous regression of transplacental metastases from maternal melanoma in a newborn: case report and review of the literature

“…In these cases, frequently, advanced-stage disease was recovered at the time of diagnosis, and the prognosis of melanoma diagnosed later than the second stage is poor. During gestation, it is better to use MRI than CT scanning for melanoma staging to avoid foetal radiation exposure; chest X-ray may be taken using appropriate shielding [18][19][20].…”

Metastatic amelanotic nodular melanoma during pregnancy

“…Pregnancy may be terminated or continued, and the management planned accordingly. Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our and other reported cases (13). Such patients seem to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.…”

“…The wish to have a healthy child meets the potentially deadly cancer disease. Some recently published cases as well as our case illustrate that management of advanced disease during pregnancy is more complicated and meets a conflict between optimal maternal therapy and fetal or neonatal well being (13,16,25). Therapeutic, familial, and social considerations must be addressed and decided in an individualized manner.…”

Small bowel obstruction: a recurrence of melanoma during the second trimester of pregnancy

“…In the past, most women diagnosed with metastatic melanoma during pregnancy have either delivered at term and had poor outcomes with mortality within 12 months from metastatic treatment refractory disease or opted for pregnancy termination. 7 There has been one previously published case report in which a woman was delivered prematurely at 28 weeks, received combination chemotherapy but died four months after delivery. Sadly, the baby died of septicemia at three months of age, a common complication of preterm delivery.…”

Spontaneous regression of transplacental metastases from maternal melanoma in a newborn: case report and review of the literature

“…In these cases, frequently, advanced-stage disease was recovered at the time of diagnosis, and the prognosis of melanoma diagnosed later than the second stage is poor. During gestation, it is better to use MRI than CT scanning for melanoma staging to avoid foetal radiation exposure; chest X-ray may be taken using appropriate shielding [18][19][20].…”

Metastatic amelanotic nodular melanoma during pregnancy

“…Pregnancy may be terminated or continued, and the management planned accordingly. Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our and other reported cases (13). Such patients seem to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.…”

“…The wish to have a healthy child meets the potentially deadly cancer disease. Some recently published cases as well as our case illustrate that management of advanced disease during pregnancy is more complicated and meets a conflict between optimal maternal therapy and fetal or neonatal well being (13,16,25). Therapeutic, familial, and social considerations must be addressed and decided in an individualized manner.…”

Small bowel obstruction: a recurrence of melanoma during the second trimester of pregnancy

“…In the past, most women diagnosed with metastatic melanoma during pregnancy have either delivered at term and had poor outcomes with mortality within 12 months from metastatic treatment refractory disease or opted for pregnancy termination. 7 There has been one previously published case report in which a woman was delivered prematurely at 28 weeks, received combination chemotherapy but died four months after delivery. Sadly, the baby died of septicemia at three months of age, a common complication of preterm delivery.…”

Spontaneous regression of transplacental metastases from maternal melanoma in a newborn: case report and review of the literature

“…In these cases, frequently, advanced-stage disease was recovered at the time of diagnosis, and the prognosis of melanoma diagnosed later than the second stage is poor. During gestation, it is better to use MRI than CT scanning for melanoma staging to avoid foetal radiation exposure; chest X-ray may be taken using appropriate shielding [18][19][20].…”