Lack of detection of human papillomavirus DNA in prostate carcinomas in patients from northeastern Brazil

Araujo-Neto, Ari P.; Ferreira-Fernandes, Hygor; Santos, Lina Gomes dos; Freitas, Antônio Carlos de; Silva-Neto, Jacinto C; Rey, Juan A.; Burbano, Rommel Rodrı́guez; Silva, Benedito B. da; Pinto, Giovanny R.

doi:10.1590/1678-4685-gmb-2015-0122

Cited by 7 publications

(7 citation statements)

References 29 publications

(44 reference statements)

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“…On the contrary, two previous studies performed in Brazil yielded opposite results and reported no significant association between HPV infection and prostate cancer (14,28). The data from a previous study in Iran also showed the presence of HPV DNA in 17.2% of prostate tumor samples and reported no significant role for HPV infection to play in prostatic disease (29).…”

Section: Discussionmentioning

confidence: 83%

Infection with Human Papillomavirus as a Potential Risk Factor for Prostate Cancer: A Case-control Study

Moghadam

Nowroozi

et al. 2021

Arch Clin Infect Dis

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Background: Prostate cancer is one of the most frequent cancers in men, with several risk factors, including infection. In this study, we aimed to assess the association of human papillomavirus (HPV) infection with prostate cancer risk and aggressiveness. Methods: This case-control study was performed on a total of 70 archival formalin-fixed paraffin-embedded (FFPE) prostatic tissue blocks. Among them, 35 histopathologically confirmed prostate cancer tissues and 35 benign prostate hyperplasia (BPH) samples were enrolled as cases and controls, respectively. The specimens were examined by the polymerase chain reaction (PCR) and in situ hybridization for the detection of HPV DNA of both low-risk (6, 11) and high-risk (16, 18) types. Results: The primary results of PCR for the L1 region revealed HPV infection in 34.3% and 8.6% of the cases and controls, respectively (P = 0.018). The HPV typing using hybridization revealed a significant difference between the two groups in terms of infection with HPV types 16 and 18 (P = 0.003, P = 0.028, respectively). The findings showed no significant association of HPV infection with age and prostate specific antigen (PSA) level of the patients. In addition, no significant association was found between infection with HPV and Gleason score (GS). Conclusions: Our findings indicated that HPV infection, especially with high-risk types 16 and 18, has a significant association with prostatic carcinogenesis. In addition, although patients with GS = 7 showed higher rates of infection with HPV, we did not observe any statistical association between HPV infection and GS.

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Section: Discussionmentioning

confidence: 83%

Infection with Human Papillomavirus as a Potential Risk Factor for Prostate Cancer: A Case-control Study

Moghadam

Nowroozi

et al. 2021

Arch Clin Infect Dis

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“…Araujo-Neto et al . 35 and Sfanos et al . 36 used conventional PCR as a form of DNA extraction and did not find HPV in PCa tissue samples in their studies.…”

Section: Discussionmentioning

confidence: 93%

Presence of HPV in prostate tissue from patients submitted to prostate biopsy

et al. 2022

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“…High-risk HPV16 and HPV18 infection rate in cervical cancer patients was 50 and 20%, respectively ( 19 ). DNA fragment of high-risk HPV inserts into host genome to disrupt the stability of the genome, so as to induce neoplastic transformation ( 20 ). This study found that the positive rate of HPV in the cervical cancer group was 100%, which was significantly higher than that of the CIN I, CIN II–III and control groups (P<0.05).…”

Section: Discussionmentioning

confidence: 99%

Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection

Min

2018

Oncol Lett

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This study investigated the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasia (CIN) and the correlation with human papillomavirus infection. A total of 110 patients with cervical lesions undergoing surgical treatment in Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine from 2016 to 2017 were selected. Those patients included 36 cases of cervical cancer and 74 cases of CIN. At the same time, 30 cases of chronic cervicitis were selected as the control group. RT-qPCR was used to detect the expression of IL-10 and Ki-67 in cervical tissue. PCR was used to detect HPV infection in cervical tissue. The expression levels of IL-10 and Ki-67 in the cervical cancer and CIN groups were higher than those in the control group. Moreover, the expression levels of IL-10 and Ki-67 in the cervical cancer and CIN II–III groups were higher than those in the CIN I group (P<0.05). In addition, the expression levels of IL-10 and Ki-67 in the cervical cancer group were significantly higher than those in the CIN II–III group. Furthermore, the expression levels of IL-10 and Ki-67 were positively correlated with HPV infection (r=0.783 or 0.712, P<0.05). Finally, the expression levels of IL-10 and Ki-67, and HPV infection in the cervical lesions studied were significantly different. Therefore, combined detection of IL-10, Ki-67 and HPV infection can improve the diagnosis of CIN and early cervical cancer.

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Lack of detection of human papillomavirus DNA in prostate carcinomas in patients from northeastern Brazil

Cited by 7 publications

References 29 publications

Infection with Human Papillomavirus as a Potential Risk Factor for Prostate Cancer: A Case-control Study

Infection with Human Papillomavirus as a Potential Risk Factor for Prostate Cancer: A Case-control Study

Presence of HPV in prostate tissue from patients submitted to prostate biopsy

Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection

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