Lack of Correlation of WAIS Digit Span with Clox 1 and the Dementia Rating Scale in MCI

Lortie, Jevin; Remington, Ruth; Hoffmann, Heather; Shea, Thomas B.

doi:10.1155/2012/829743

Cited by 8 publications

(6 citation statements)

References 22 publications

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“…For instance, working memory performance has predictive value in MCI patients with respect to conversion to dementia. 18 - 19 Although the present findings showed that deficits are present in verbal and visuospatial memory, not all currently available working memory tests reveal impairments. A promising approach may lie in novel working memory paradigms that rely on the episodic buffer.…”

Section: Discussioncontrasting

confidence: 62%

Assessment of verbal and visuospatial working memory in mild cognitive impairment and Alzheimer's dementia

Kessels

Overbeek

Bouman

2015

Dement. neuropsychol.

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In addition to episodic memory impairment, working memory may also be compromised in mild cognitive impairment (MCI) or Alzheimer's dementia (AD), but standard verbal and visuospatial span tasks do not always detect impairments.ObjectiveTo examine whether more complex verbal and visuospatial working memory tasks result in more reliable impairment detection.MethodsThe Digit Span (forward, backward and sequencing), Spatial Span (forward and backward) and Spatial Addition test from the Wechsler batteries were administered to MCI and AD patients and performance compared to healthy older adult controls.ResultsResults showed that both the MCI and AD patients had impaired performance on the Spatial Addition test. Both groups also had impaired performance on all three Digit Span conditions, but no differences were found between forward and backward conditions in any of the groups. The sequencing condition differed from the backward condition only in the AD group. Spatial Span performance was impaired in AD group patients but not in MCI patients.ConclusionWorking memory deficits are evident in MCI and AD even on standard neuropsychological tests. However, available tests may not detect subtle impairments, especially in MCI. Novel paradigms tapping the episodic buffer component of working memory may be useful in the assessment of working memory deficits, but such instruments are not yet available for clinical assessment.

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Section: Discussioncontrasting

confidence: 62%

Assessment of verbal and visuospatial working memory in mild cognitive impairment and Alzheimer's dementia

Kessels

Overbeek

Bouman

2015

Dement. neuropsychol.

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“…From a clinical perspective, working memory assessment is important. For example, working memory performance has predictive value in patients with MCI with respect to the development of dementia [38,39]. Although episodic deficits during disease progression have been widely investigated and are the benchmark of a probable diagnosis of AD, more recent research has investigated working memory and executive function decline during MCI, also referred to as the preclinical stage of AD.…”

Section: Discussionmentioning

confidence: 99%

Combined Intervention of Physical Activity, Aerobic Exercise, and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study

Park

et al. 2019

JCM

100

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This study aimed to investigate the association between a dual-task intervention program and cognitive and physical functions. In a randomized controlled trial, we enrolled 49 individuals with MCI. The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the MMSE and modified Alzheimer’s disease Assessment Scale-Cognitive Subscale (ADAS-Cog), both at baseline and at 3 months follow-up. The program comprised physical activity and behavior modification, aerobic exercise, and a cognitive and exercise combined intervention program. Analysis of the subjects for group-time interactions revealed that the exercise group exhibited a significantly improved ADAS-Cog, working memory, and executive function. Total physical activity levels were associated with improvements in working memory function and the modified ADAS-Cog score, and the associations were stronger for daily moderate intensity activity than for daily step count. The 24-week combined intervention improved cognitive function and physical function in patients with MCI relative to controls. Encouraging participants to perform an additional 10 min of moderate physical activity under supervision, during ongoing intervention, may be more beneficial to prevent cognitive decline and improve exercise adherence.

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“…Recent case reports have also provided anecdotal evidence associating chronic N 2 O use with subacute combined degeneration and limb weakness [12], myeloneuropathy [13], pernicious anemia [14], hematologic changes and risk of thrombosis [15,16], myocardial infarction [17], pneumomediastinum [18], vitamin B12 deficiency with lower motor neuronal degeneration [19,20], and stroke [21], and many conditions that are considered significant risk factors for AD onset, including headache [22], anemia [23], gait imbalance/ataxia [24], thrombosis [25], stroke [26], and myocardial infarction [27]. Moreover, clinical evidence suggests that trace N 2 O exposure induces impairments in the Digit Span Test [28], a test that has predictive power in identifying cognitive decline in participants with mild cognitive impairment (MCI)—a condition often prodromal to AD [29].…”

Section: Environmental Nitrous Oxide (N2o) Exposure and Ad Pathologymentioning

confidence: 99%

A model of lipid dysregulation and altered nutrient status in Alzheimer's disease

Fluegge

2019

A&D Transl Res & Clin Interv

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Introduction Dysregulated lipid metabolism and nutrient status are thought to play a role in the pathophysiology of Alzheimer's disease (AD). However, the precise involvement is not well understood, and it remains unclear exactly how such dysregulated lipid metabolism and altered nutrient status, especially changes in phosphatidylcholine, B12, and folate, are connected to the hallmark pathology in AD (i.e., amyloidogenesis). Methods We have postulated that genetic susceptibility (i.e., APOE ε4/ε4) to environmental exposure to emissions of nitrous oxide (N 2 O) could underlie the onset of AD and its early neuropsychiatric correlates Results and Discussion The current theoretical editorial describes, using clinical, preclinical, and in vitro evidences, how this model contributes not only to amyloidogenesis but also other nonopioid effects, specifically altered lipid metabolism, depletion of vitamin B12, and disruption of the folate-mediated one carbon metabolic pathway.

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Lack of Correlation of WAIS Digit Span with Clox 1 and the Dementia Rating Scale in MCI

Cited by 8 publications

References 22 publications

Assessment of verbal and visuospatial working memory in mild cognitive impairment and Alzheimer's dementia

Assessment of verbal and visuospatial working memory in mild cognitive impairment and Alzheimer's dementia

Combined Intervention of Physical Activity, Aerobic Exercise, and Cognitive Exercise Intervention to Prevent Cognitive Decline for Patients with Mild Cognitive Impairment: A Randomized Controlled Clinical Study

A model of lipid dysregulation and altered nutrient status in Alzheimer's disease

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