Lack of Blood Pressure-lowering Effect of Renal Denervation in a Drug-naïve Patient with Pronounced Arterial Stiffening

Arx, Robert von; Rexhaj, Emrush; Allemann, Yves; Moschovitis, Aris; Windecker, Stephan; Meier, Bernhard; Scherrer, Urs; Rimoldi, Stefano F.

doi:10.1016/j.amjmed.2014.05.024

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…An important observation in this context is that pulse pressure (ie, systolic BP – diastolic BP) represents a valid and widely available parameter for estimating the degree of age‐related vascular stiffening . Arterial stiffness is an independent predictor of cardiovascular morbidity and mortality and has been identified as a key factor associated with isolated hypertension, secondary hypertension, and therapy‐resistant hypertension . Accordingly, in many clinical trials, sustained systolic BP elevation is the main component responsible for poor BP control .…”

Section: Discussionmentioning

confidence: 99%

“…22 Arterial stiffness is an independent predictor of cardiovascular morbidity and mortality 22,23 and has been identified as a key factor associated with isolated hypertension, 24 secondary hypertension, 25 and therapyresistant hypertension. 26 Accordingly, in many clinical trials, sustained systolic BP elevation is the main component responsible for poor BP control. 14,27 In general, a decrease of central BP can be obtained by destiffening of the vasculature or by modification of the reflected wave in order to "resynchronize" the forward with the backward wave.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and Safety of Calcium Channel Blocker/Diuretics Combination Therapy in Hypertensive Patients: A Meta‐Analysis

Rimoldi

Messerli

Chavez

et al. 2015

J of Clinical Hypertension

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2Although recent guidelines recommend the combination of calcium channel blockers (CCBs) and thiazide (-like) diuretics, this combination is not widely used in clinical practice. The aim of this meta-analysis was to assess the efficacy and safety of this combination regarding the following endpoints: all-cause and cardiovascular mortality, myocardial infarction, and stroke. Four studies with a total of 30,791 of patients met the inclusion criteria. The combination CCB/ thiazide (-like) diuretic was associated with a significant risk reduction for myocardial infarction (risk ratio Elderly patients with isolated systolic hypertension may particularly benefit from such a combination, since both drug classes have been shown to confer cerebrovascular protection.[

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Calcium Channel Blocker/Diuretics Combination Therapy in Hypertensive Patients: A Meta‐Analysis

Rimoldi

Messerli

Chavez

et al. 2015

J of Clinical Hypertension

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“…Patients remaining hypertensive under therapy with the combination A + C + D plus MRA should undergo 24 h ABPM and arterial stiffness assessment. Studies have shown that isolated systolic hypertension (ISH) and increased arterial stiffness are negative predictors of efficacy, and device-based interventions should therefore not be performed in those patients (45,46).…”

Section: Device-based Interventions In the Treatment Of Resistant Hyp...mentioning

confidence: 99%

Treatment-resistant hypertension

Milošević¹,

Otašević²

2022

Arhiv za farmaciju

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Treatment-resistant hypertension is one of the most significant causes of poor blood pressure regulation. Patients with resistant hypertension are at a higher risk of developing comorbidities compared to the general hypertensive population. As a result, these patients have an increased incidence of disability and premature death, as well as increased treatment costs. Due to the above-mentioned, in the last decade, there has been an increase in researchers' interest in elucidating the pathogenesis, diagnosis, and treatment of resistant hypertension. However, recent data indicate that 20% of female and 24% of male patients with arterial hypertension still have uncontrolled blood pressure, despite maximum doses of three antihypertensive drugs (including a diuretic) and appropriate lifestyle measures. New treatment modalities (i.e. devicebased interventions - catheter-based renal denervation and baroreceptor stimulation) offer hope for achieving adequate blood pressure regulation in these patients. In this paper, we have summarized previous knowledge about the mechanisms underlying the pathogenesis of resistant hypertension, as well as optimal diagnostic methods to differentiate true from pseudo-resistant hypertension. We have also given an overview of the current therapeutic approach, including optimal medical therapy and new treatment modalities (i.e. device-based interventions) and their role in the treatment of resistant hypertension.

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“…Пульсовое АД -разница между САД и ДАД -широко используемый параметр жесткости артерий. Ригидность артериальной стенки -не только ключевой фактор повышения САД с возрастом, но независимый предиктор ССЗ и смерти от них, фактор, ассоциированный с недостаточным контролем САД и резистентной АГ, главная детерминанта повышения центрального САД, которое оказывает непосредственное повреждающее действие на органы-мишени [7][8][9][10][11]. Снижение центрального САД может быть способом уменьшения жесткости сосудистой стенки или модификацией отраженной волны, чтобы «синхронизировать» ее с прямой волной.…”

Section: особенности аг в пожилом возрасте как обоснование выбора антunclassified

Indapamide SR / Amlodipine Fixed Dose Combination: Novel Approach to Effective Control of Systolic Arterial Pressure

Tkachyeva

Kotovskaya

Dudinskaya

2017

CARDIO

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2 ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава РФ-ОСП «Российский геронтологический научноклинический центр», Москва Фиксированная комбинация индапамида-ретард и амлодипина: новый подход к эффективному контролю систолического артериального давления Ключевые слова: индапамид-ретард, амлодипин, фиксированная комбинация, систолическое артериальное давление, артериальная ригидность.

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Lack of Blood Pressure-lowering Effect of Renal Denervation in a Drug-naïve Patient with Pronounced Arterial Stiffening

Cited by 7 publications

References 8 publications

Efficacy and Safety of Calcium Channel Blocker/Diuretics Combination Therapy in Hypertensive Patients: A Meta‐Analysis

Efficacy and Safety of Calcium Channel Blocker/Diuretics Combination Therapy in Hypertensive Patients: A Meta‐Analysis

Treatment-resistant hypertension

Indapamide SR / Amlodipine Fixed Dose Combination: Novel Approach to Effective Control of Systolic Arterial Pressure

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