Lack of benefi cial eff ects of granulocyte colony-stimulating factor in patients with subacute myocardial infarction undergoing late revascularization: a double-blind, randomized, placebo-controlled clinical trial

Karimabad, Hossein Mehdikhani; Shabestari, Mahmood; Baharvand, Hossein; Dizaj, Ahmad Vosough; Gourabi, Hamid; Shahverdi, Abdolhossein; Shamsian, Aliakbar; Abdolhoseini, Saeid; Moazzami, Kasra; Marjanimehr, Mehdi Moradi; Emami, Farhad; Bidkhori, Hamid Reza; Hamedanchi, Ali; Talebi, Soheila; Farrokhi, Farid; Jabbari-Azad, Farhad; Fadavi, Mahsa; Garivani, Uousef; Mahmoodi, Mahmood; Aghdami, Nasser

doi:10.1080/ac.66.2.2071254

Cited by 7 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, MI is probably the clinical setting in which HSC, and other bone marrow-derived populations, have been the most extensively studied, likely due in no small part to the fact that heart disease is one of the leading causes of death worldwide. With one exception [384], these preclinical and clinical studies have collectively provided compelling evidence that infusing HSC, or administering G-CSF to mobilize the patient’s endogenous HSC, can each lead to a reduction in infarct size, reduced left ventricular remodeling, and long-lasting functional improvement. In the one study that made a direct comparison [380], combining G-CSF injections with an infusion of mPB cells was found to be even more effective than administering G-CSF alone.…”

Section: Hsc Transplantation For Diseases Of Non-hematopoietic Orgmentioning

confidence: 99%

The hematopoietic system in the context of regenerative medicine

Porada

Atala

Almeida-Porada

2016

Methods

View full text Add to dashboard Cite

Hematopoietic stem cells (HSC) represent the prototype stem cell within the body. Since their discovery, HSC have been the focus of intensive research, and have proven invaluable clinically to restore hematopoiesis following inadvertent radiation exposure and following radio/chemotherapy to eliminate hematologic tumors. While they were originally discovered in the bone marrow, HSC can also be isolated from umbilical cord blood and can be “mobilized” peripheral blood, making them readily available in relatively large quantities. While their ability to repopulate the entire hematopoietic system would already guarantee HSC a valuable place in regenerative medicine, the finding that hematopoietic chimerism can induce immunological tolerance to solid organs and correct autoimmune diseases has dramatically broadened their clinical utility. The demonstration that these cells, through a variety of mechanisms, can also promote repair/regeneration of non-hematopoietic tissues as diverse as liver, heart, and brain has further increased their clinical value. The goal of this review is to provide the reader with a brief glimpse into the remarkable potential HSC possess, and to highlight their tremendous value as therapeutics in regenerative medicine.

show abstract

Section: Hsc Transplantation For Diseases Of Non-hematopoietic Orgmentioning

confidence: 99%

The hematopoietic system in the context of regenerative medicine

Porada

Atala

Almeida-Porada

2016

Methods

View full text Add to dashboard Cite

show abstract

Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy

Naderi‐Meshkin

Bahrami

Bidkhori

et al. 2014

Cell Biology International

100

View full text Add to dashboard Cite

Stem/progenitor cell-based therapeutic approach in clinical practice has been an elusive dream in medical sciences, and improvement of stem cell homing is one of major challenges in cell therapy programs. Stem/progenitor cells have a homing response to injured tissues/organs, mediated by interactions of chemokine receptors expressed on the cells and chemokines secreted by the injured tissue. For improvement of directed homing of the cells, many techniques have been developed either to engineer stem/progenitor cells with higher amount of chemokine receptors (stem cell-based strategies) or to modulate the target tissues to release higher level of the corresponding chemokines (target tissue-based strategies). This review discusses both of these strategies involved in the improvement of stem cell homing focusing on mesenchymal stem cells as most frequent studied model in cellular therapies.

show abstract

Tissue Engineering and Regenerative Medicine in Iran: Current State of Research and Future Outlook

et al. 2015

View full text Add to dashboard Cite

During two decades ago, Iran has exhibited remarkable increase in scientific publication in different aspects including tissue engineering and regenerative medicine (TERM). The field of TERM in Iran dates comes back to the early part of the 1990 and the advent of stem cell researches. Nowadays, Iran is one of the privileged countries in stem cell therapy in the Middle East. The next major milestone in TERM was application and fabrication of scaffolds for tissue engineering in the early 2000s with a focus on engineering bone and cartilage tissue. A good amount of thoughtful works has also yielded prototypes of other tissue substitutes such as nerve conduits, liver, and even heart. However, forward movement to clinical application of these products is still far from offering clinically acceptable solutions. In this study, we have presented a comprehensive review on the efforts of Iranian scientists in different issues of tissue engineering and regenerative medicine field.

show abstract

Lack of benefi cial eff ects of granulocyte colony-stimulating factor in patients with subacute myocardial infarction undergoing late revascularization: a double-blind, randomized, placebo-controlled clinical trial

Abstract: G-CSF administration is safe, but not effective, in improving impaired LV functional parameters in patients with subacute MI who had an impaired baseline EF of less than 45%.

Cited by 7 publications

References 0 publications

The hematopoietic system in the context of regenerative medicine

The hematopoietic system in the context of regenerative medicine

Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy

Tissue Engineering and Regenerative Medicine in Iran: Current State of Research and Future Outlook

Contact Info

Product

Resources

About