Lack of BCL10 mutations in Hodgkin's disease‐derived cell lines

Abstract

Summary.The pathogenetic events leading to the malignant transformation of Hodgkin±Reed±Sternberg cells are unknown. As Hodgkin±Reed±Sternberg cells are resistant to CD95-mediated apoptosis and chromosomal aberrations involving the 1p22 region harbouring the proapoptotic BCL10 gene represent a recurrent event in Hodgkin's disease-derived cell lines, analysis of the BCL10 gene and its transcripts was performed. As transcription of wild-type BCL10 was detected in all Hodgkin's diseasederived cell lines analysed, alterations of the coding sequence of the BCL10 gene are unlikely to contribute to the malignant transformation of the Hodgkin±Reed±Sternberg cell.

Analysis of CARMA1/BCL10/MALT1 expression in Reed – Sternberg cells of classical Hodgkin lymphoma

“…Wild-type transcripts of the BCL10 genes are detected in H-RS cell lines [4] although primary H-RS cell lack the B cell antigen receptor. In the present study, we asked for the pathogenetic role of CARMA1, BCL10 and MALT1 in the context of cHL.…”