Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence

Moraes, Leonardo Nazário de; Borges, Mauricio; Sousa, Patrícia; Vênere, Paulo César; Souza, Ive Lima

doi:10.4238/2012.june.15.10

Cited by 3 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their association with NPC has been reported in some ethnic groups (Tiwawech et al, 2006;Murthy et al, 2013;Russo et al, 2013;Wei et al, 2013;Yang et al, 2015) [. However, non-association has also been reported in many studies (Cheng et al, 2003;Rossini et al, 2007;Boccia et al, 2008;Moraes et al, 2012). The levels of expression and catalytic activities of and GSTM1 and GSTT1 enzymes in NPC, and their metabolic balance, may be an important determinant host factor underlying NPC.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India, the Northeastern Region

Lourembam

Singh²,

Sharma³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

generally been classified as high-or low-incidence areas, the racial/ethnic distribution of NPC within regions is far from uniform (Chang and Adami, 2006). In the southeastern Chinese province of Guangdong, where the overall NPC incidence rate is >20 per 100,000 personyears among males, rates in Cantonese speakers are double those in other dialect groups such as the Hakka, Hokkien, and Chiu Chau (Parkin et al., 2002;Chang and Adami, 2006). Likewise, in the Malaysian state of Selangor, rates in Chinese residents have historically been highest among Cantonese, intermediate among Khek, and lowest among Hokkien and Teochiu (Parkin et al.

show abstract

Section: Discussionmentioning

confidence: 97%

Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India, the Northeastern Region

Lourembam

Singh²,

Sharma³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…This indicates that CYP1A1 MspI mutant genotypes contribute to familial aggregation. However, Moraes et al (2012) did not discover any obvious correlation between CYP1A1 MspI gene polymorphism and tumor occurrence among Brazilian families with very high tumor incidence. This discrepancy may be explained by ethnic differences.…”

Section: Discussionmentioning

confidence: 99%

Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang

Zeng¹,

Y²,

Hf³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. This study aimed to investigate the correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer (EC) among the Kazakh ethnic group in Xinjiang. CYP1A1 and GSTM1 gene polymorphisms were detected using peripheral blood from 86 subjects belonging to families with EC and 82 control subjects. Additionally, a questionnaire survey was conducted to ascertain environmental risk factors. Combined effects of CYP1A1 and GSTM1 gene polymorphisms and environmental factors in familial aggregation of EC were evaluated. Distribution frequencies of CYP1A1 MspI and GSTM1 genotypes between EC and control families showed significant differences (P = 0.002, P = 0.001). Contribution of interaction between CYP1A1 MspI mutant and GSTM1 deletion polymorphisms to familial aggregation of EC was significant, with OR = 3.571 (95%CI = 1.738-3.346). Logistic multivariate analysis indicated that familial aggregation of EC is correlated with 3 factors: drinking water, intake of fresh vegetables and fruits, and CYP1A1 MspI polymorphism (P = 0.005, P = 0.013, and In conclusion, CYP1A1 and GSTM1 gene polymorphisms affect familial aggregation of EC among the Kazakh ethnic group in Xinjiang. River water intake and CYP1A1 MspI polymorphism were risk factors that likely contributed to high incidence of EC among families.

show abstract

Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

et al. 2014

View full text Add to dashboard Cite

Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1, GSTT1, and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. The results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher's exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed (χ(2) = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.

show abstract

Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence

Cited by 3 publications

References 30 publications

Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India, the Northeastern Region

Evaluation of Risk Factors for Nasopharyngeal Carcinoma in a High-risk Area of India, the Northeastern Region

Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang

Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

Contact Info

Product

Resources

About